A5101888850- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Blood properties and coagulation
- Tryptophan and brain disorders
- Vitamin C and Antioxidants Research
- Adipose Tissue and Metabolism
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Liver Disease Diagnosis and Treatment
- Atherosclerosis and Cardiovascular Diseases
- Regulation of Appetite and Obesity
- Signaling Pathways in Disease
- Erythrocyte Function and Pathophysiology
- Cancer, Hypoxia, and Metabolism
- Trace Elements in Health
- Vitamin K Research Studies
- Lipid metabolism and disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Bone and Joint Diseases
- Breastfeeding Practices and Influences
- DNA Repair Mechanisms
- Alcohol Consumption and Health Effects
- Blood groups and transfusion
- Menopause: Health Impacts and Treatments
- Circadian rhythm and melatonin
- Public Health and Nutrition
Izmir Kâtip Çelebi University
2024
Istanbul University
2010-2023
Haliç University
2016
Free radical-mediated oxidative stress has been implicated in adverse tissue changes a number of diseases. In view the role processes non-insulin dependent diabetes mellitus (NIDDM), this study, we investigated oxidant and antioxidant status plasma patients with NIDDM effect vitamin E (800 IU/day) supplementation on stress, defense system, fructosamine levels insulin action. Thirty controls 40 were studied. patients, lipids, E, lipid peroxide, total thiols (t-SH), superoxide peroxidase (SOD)...
Polymorphisms in DNA repair genes may be associated with differences the efficiency of damage and influence an individual's risk atherosclerosis. Genetic research on coronary artery disease (CAD) has traditionally focused investigation aimed at identifying disease-susceptibility genes. The aim this study was to investigate relationship between AP-endonuclease-1 (Asp148Glu), XRCC1 (Arg399Gln), XRCC3 (Thr241Met), XPD (Lys751Gln), XPG (Asp1104His), hOGG1 (Ser326Cys), gene polymorphisms...
We aimed to investigate the effects of melatonin administered before and during endotoxemia on lung tissue rats, cytokine, YKL-40, matrix metalloproteinase (MMP) inhibitor levels, oxidative stress parameters, energy balance. Sepsis was induced with lipopolysaccharide (LPS), cell wall molecule gram negative bacteria. Rats were divided into four groups, Control, LPS (Escherichia coli O127:B8, 20 mg/kg), (10 melatonin+LPS (M+LPS). After injections, tissues samples taken for experimental...
Oxidative stress is suggested to play an important role in the pathogenesis of cardiovascular disease (CVD). Various hormone replacement therapy (HRT) protocols are used reduce CVD risk postmenopausal women. Recent studies found that HRT lowers lipid levels and improves vascular endothelial function In this study effects on plasma platelet membrane fatty acid composition oxidant-antioxidant system women investigated. Blood samples were obtained from 50 Before starting treatment, all...
Galectins constitute of a soluble mammalian β-galactoside binding lectin family, which play homeostatic roles in the regulation cell cycle, and apoptosis, addition to their inflammatory conditions. Galectin-3 has an important role various conditions including endotoxemia, airway inflammation. Statins, key precursor inhibitors 3-hydroxyl-3-methyl coenzyme A (HMG-CoA) reductase, may prevent progression inflammation sepsis after prior statin treatment. Endotoxemia leads formation oxidative...
Most of the studies concerning effects cyclosporin A (Cs A) on red blood cell (RBC) rheology were carried out in human transplant recipients who may still have residual insufficiency and concomitant administration other immunosuppressive antihypertensive drugs. The aim this study is to evaluate Cs membrane composition nontransplant healthy rats. Female Wistar albino rats divided into two groups 10 animals each. Rats received mg/kg A, i.p. or saline for 4 weeks. significantly increased RBC...
There are a number of studies investigating anti-inflammatory effects simvastatin in patients with sepsis and animal models. few which investigated effect on elements sepsis. In the present study, impact pretreatment element levels was evaluated liver during endotoxemia. Rats were divided into control, LPS, simvastatin, + LPS. The histopathologic examination performed using hematoxylin eosin. Selenium, zinc, iron, manganese, magnesium, copper analyzed inductively coupled plasma – optical...
Background: There are limited studies in the literature micro and macro elements of level during early phase sepsis.The changes element levels plays important roles normal physiologic states pathological especially inflammation.Intestine is main organ for absorption element.There a lot shown that simvastatin possess potent anti-inflammation antioxidation capacity.But it not clear on its mechanism.Aim: This study aimed to observe effect prior treatment with intestinal tissue rats early-phase...
Objective: In a previous study we showed that red cell deformability was decreased in cats with non-insulin dependent diabetes mellitus (NIDDM) and it associated abnormalities various rheological parameters (blood plasma viscosity, erythrocyte deformability, hemotological parameters) as well alterations membrane proteins. On the other hand, there is limited data concerning contribution of lymphocyte protein increased rigidity to impaired blood rheology diabetes. present study, aimed...
Abstract Encephalopathy develops following sepsis, which is defined as life-threatening organ failure due to the irregular response of a host infection. It has high mortality and morbidity rates. In this study, we aimed investigate effects inflammation on brain tissue, gamma-aminobutyric acid-A (GABAA) receptor antagonist bicuculline in rats with sepsis. Sepsis was experimentally generated using lipopolysaccharide (LPS). The were divided into four groups control, LPS (10 mg/kg i.p.), (1.5...