Rintu Kutum
A5010846438- SARS-CoV-2 and COVID-19 Research
- Traditional Chinese Medicine Studies
- RNA Research and Splicing
- Computational Drug Discovery Methods
- MicroRNA in disease regulation
- COVID-19 epidemiological studies
- Cancer-related molecular mechanisms research
- Tuberculosis Research and Epidemiology
- Genomics and Rare Diseases
- Mycobacterium research and diagnosis
- COVID-19 Clinical Research Studies
- Preterm Birth and Chorioamnionitis
- Genomics and Phylogenetic Studies
- Cell Image Analysis Techniques
- Pharmacogenetics and Drug Metabolism
- Oral Health Pathology and Treatment
- Gene expression and cancer classification
- Ovarian function and disorders
- Research Data Management Practices
- Bioinformatics and Genomic Networks
- Plant-based Medicinal Research
- Data Mining Algorithms and Applications
- Meta-analysis and systematic reviews
- Machine Learning in Bioinformatics
- Alzheimer's disease research and treatments
Indraprastha Institute of Information Technology Delhi
2021-2025
Institute of Genomics and Integrative Biology
2014-2024
Academy of Scientific and Innovative Research
2016-2024
Ashoka University
2022-2024
University of Dundee
2023
Council of Scientific and Industrial Research
2014-2022
Haldia Institute of Technology
2022
UiT The Arctic University of Norway
2022
National Institute of Technology Durgapur
2022
XIM University
2022
When it becomes completely possible for one to computationally forecast the impacts of harmful substances on humans, would be easier attempt addressing shortcomings existing safety testing chemicals. In this paper, we relay outcomes a community-facing DREAM contest prognosticate nature environment-based compounds, considering their likelihood have disadvantageous health-related effects human populace. Our research quantified cytotoxicity levels in 156 compounds across 884 lymphoblastic lines...
Identification of pregnancies at risk preterm birth (PTB), the leading cause newborn deaths, remains challenging given syndromic nature disease. We report a longitudinal multi-omics study coupled with DREAM challenge to develop predictive models PTB. The findings indicate that whole-blood gene expression predicts ultrasound-based gestational ages in normal and complicated (r = 0.83) and, using data collected before 37 weeks gestation, also delivery date both 0.86) those spontaneous 0.75)....
The global efforts to control COVID-19 are threatened by the rapid emergence of novel SARS-CoV-2 variants that may display undesirable characteristics such as immune escape, increased transmissibility or pathogenicity. Early prediction for new strains with these features is critical pandemic preparedness. We present Strainflow , a supervised and causally predictive model using unsupervised latent space genome sequences. was trained validated on 0.9 million sequences period December, 2019...
Asthma is a complex, heterogeneous disorder with similar presenting symptoms but varying underlying pathologies. Exhaled breath condensate (EBC) relatively unexplored matrix which reflects the signatures of respiratory epithelium, difficult to normalize for dilution. Here we explored whether internally normalized global NMR spectrum patterns, combined machine learning, could be useful diagnostics or endotype discovery. Nuclear magnetic resonance (NMR) spectroscopy EBC was performed in 89...
In Ayurveda system of medicine individuals are classified into seven constitution types, "Prakriti", for assessing disease susceptibility and drug responsiveness. Prakriti evaluation involves clinical examination including questions about physiological behavioural traits. A need was felt to develop models accurately predicting classes that have been shown exhibit molecular differences. The present study carried out on data phenotypic attributes in 147 healthy three extreme from a genetically...
Abstract Background Intestinal tuberculosis (ITB) and Crohn’s disease (CD) mimic each other clinically, endoscopically, radiologically are difficult to differentiate. This is a major barrier make an early diagnosis of CD in TB endemic areas. We aimed develop high accuracy machine learning-based model which could be easily implemented innovative way. Methods retrospectively analyzed data from 1066 patients. After cleaning, 796 patients (514 & 282 ITB) 28 variables were included. A super...
Growing evidence suggests the importance of lipid metabolism in pathogenesis tuberculosis. Neutral lipids form majority a caseous granuloma, pathology characteristic Cytosolic droplets (LDs) macrophages store house these and have been demonstrated to contribute inflammatory response infection. The proteome reflects mechanisms active under condition. However, infection induced changes dynamic organelles remains elusive. Here, we employed quantitative proteomics identify alterations upon with...
Antiepileptic drug therapy has significant inter-patient variability in response towards it. The current study aims to understand this at the molecular level using microarray-based analysis of peripheral blood gene expression profiles patients receiving valproate (VA) monotherapy. Only 10 unique genes were found be differentially expressed VA responders (n = 15) and 6 non-responders 8) (fold-change >2, p < 0.05). PTGS2 which encodes cyclooxygenase-2, COX-2, showed downregulation compared...
To understand the spread of SARS-CoV2, in August and September 2020, Council Scientific Industrial Research (India) conducted a serosurvey across its constituent laboratories centers India. Of 10,427 volunteers, 1058 (10.14%) tested positive for SARS-CoV2 anti-nucleocapsid (anti-NC) antibodies, 95% which had surrogate neutralization activity. Three-fourth these recalled no symptoms. Repeat serology tests at 3 (n = 607) 6 175) months showed stable anti-NC antibodies but declining Local...
Cerebellar ataxias (CAs) represent a group of autosomal dominant and recessive neurodegenerative disorders affecting cerebellum with or without spinal cord. Overall, CAs have preponderance for tandem nucleotide repeat expansions as an etiological factor (10 TREs explain nearly 30-40% ataxia cohort globally). The experience 10 years common genetic subtypes ≈5600 patients' referrals (Pan-India) received at single center is shared herein. Frequencies (in %, n) SCA types FRDA in the sample are...
The current TB treatment regimen involves a combination of drugs administered for an extended duration that could last 6 months to 2 years. This lead noncompliance and the emergence newer drug resistance strains.
In recent decades, dengue has been expanding rapidly in the tropical cities. Even though environmental factors and landscape features profoundly impact vector abundance disease epidemiology, significant gaps exist understanding role of local heterogeneity on epidemiology India. this study, we assessed remotely sensed climatic (rainfall, temperature humidity) variables (land use pattern, vegetation built up density) incidence (2012–2019) Bhopal city, Central Dengue hotspots city were through...
Precision medicine aims to move from traditional reactive a system where risk groups can be identified before the disease occurs. However, phenotypic heterogeneity amongst diseased and healthy poses major challenge for identification markers stratification early actionable interventions. In Ayurveda, individuals are phenotypically stratified into seven constitution types based on multisystem phenotypes termed "Prakriti". It enables prediction of health trajectories selection We hypothesize...
Open and reproducible research practices increase the reusability impact of scientific research. The reproducibility results is influenced by many factors, most which can be addressed improved education training. Here we describe how workshops developed Reproducibility for Everyone (R4E) initiative customized to provide researchers at all career stages across disciplines with training in practices. R4E initiative, led volunteers, has reached more than 3000 worldwide date, workshop materials,...
Abstract We report the construction of a novel Systems Biology based virtual drug discovery model for prediction non-toxic metabolic targets in Mycobacterium tuberculosis (Mtb). This is on data-intensive genome level analysis and principle conservation evolutionarily important genes. In 1623 sequenced Mtb strains, 890 genes identified through systems approach were evaluated non-synonymous mutations. The 33 showed none or one variation entire including 1084 Russian MDR strains. These...
Admixture mapping has been enormously resourceful in identifying genetic variations linked to phenotypes, adaptation, and diseases. In this study through analysis of copy number variable regions (CNVRs), we report extensive restructuring the genomes recently admixed African-Indian population (OG-W-IP) that inhabits a highly saline environment Western India. The included subjects from OG-W-IP (OG), five different Indian three HapMap populations were genotyped using Affymetrix version 6.0...
Recent technological developments allow us to measure the status of dozens proteins in individual cells. This opens way understand heterogeneity complex multi-signaling networks across cells and cell types, with important implications treat diseases such as cancer. These technologies are, however, limited for which antibodies are available fairly costly, making predictions new markers existing under conditions a valuable alternative. To assess our capacity make boost further methodological...
Abstract Immunization is expected to confer protection against infection and severe disease for vaccines while reducing risks unimmunized populations by inhibiting transmission. Here, based on serial serological studies of an observational cohort healthcare workers, we show that during a Severe Acute Respiratory Syndrome -Coronavirus 2 Delta-variant outbreak in Delhi, 25.3% (95% Confidence Interval 16.9-35.2) previously uninfected, ChAdOx1-nCoV19 double vaccinated, workers were infected...
Abstract Personalized medicine relies on successful identification of genome-wide variations that governs inter-individual differences in phenotypes and system level outcomes. In Ayurveda, assessment composite constitution types “ Prakriti” forms the basis for risk stratification, predicting health disease trajectories personalized recommendations. Here, we report a novel method identifying pleiotropic genes variants associate with healthy individuals three extreme contrasting constitutions...
Alu repeats contribute to phylogenetic novelties in conserved regulatory networks primates. Our study highlights how exonized Alus could nucleate large-scale mRNA-miRNA interactions. Using a functional genomics approach, we characterize transcript isoform of an orphan gene, CYP20A1 (CYP20A1_Alu-LT) that has exonization 23 its 3'UTR. CYP20A1_Alu-LT, confirmed by 3'RACE, is outlier length (9 kb 3'UTR) and widely expressed. publically available data sets, demonstrate expression higher primates...
Abstract Hyperactivation of cyclin-dependent kinase 5 (Cdk5) by p25, contributes to neuroinflammation causing neurodegeneration in Parkinson’s disease (PD) and Alzheimer’s disease. However, the mechanism which Cdk5 induces PD brain is largely unexplored. Here, we show that phosphorylates cytosolic phospholipase A2 (cPLA2) at Thr-268 Ser-505 sites lead its activation generation eicosanoid products. Mutational studies using site-directed mutagenesis molecular simulations architecture protein...