A5006556655- Bioinformatics and Genomic Networks
- Receptor Mechanisms and Signaling
- Gene Regulatory Network Analysis
- Hematopoietic Stem Cell Transplantation
- Healthcare professionals’ stress and burnout
- Virus-based gene therapy research
- Simulation-Based Education in Healthcare
- Clinical Reasoning and Diagnostic Skills
- Acne and Rosacea Treatments and Effects
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Renal Transplantation Outcomes and Treatments
- Computational Drug Discovery Methods
- RNA Interference and Gene Delivery
- Transgenic Plants and Applications
- Cardiac tumors and thrombi
- Non-Invasive Vital Sign Monitoring
- Cardiac Arrest and Resuscitation
- Hemodynamic Monitoring and Therapy
- Cellular Mechanics and Interactions
- Mesenchymal stem cell research
- Nanowire Synthesis and Applications
- Advanced Drug Delivery Systems
- Advancements in Transdermal Drug Delivery
- Contact Dermatitis and Allergies
Yale University
2022-2025
University of Michigan–Ann Arbor
2017
When it becomes completely possible for one to computationally forecast the impacts of harmful substances on humans, would be easier attempt addressing shortcomings existing safety testing chemicals. In this paper, we relay outcomes a community-facing DREAM contest prognosticate nature environment-based compounds, considering their likelihood have disadvantageous health-related effects human populace. Our research quantified cytotoxicity levels in 156 compounds across 884 lymphoblastic lines...
Introduction: Emergency medicine is characterized by high volume decision-making while under multiple stressors. With the arrival of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus in early 2020, physicians across world were met with a surge critically ill patients. (EP) are prone to developing burnout and post-traumatic stress disorder (PTSD), due experiencing emotional trauma as well cumulative practice. Thus, calls have been made for attempts prevent physician PTSD...
Abstract Current treatments for T cell malignancies encounter issues of disease relapse and off-target toxicity. Using receptor (TCR)Vβ2 as a model, here we demonstrate the rapid generation an off-the-shelf allogeneic chimeric antigen (CAR)-T platform targeting clone-specific TCR Vβ chain malignant killing while limiting normal destruction. Healthy donor cells undergo CRISPR-induced TRAC , B2M CIITA knockout to eliminate cell-dependent graft-versus-host host-versus-graft reactivity. Second...
Background Acne vulgaris affects a significant number of females into adulthood. Juvenile acne and adult have different presentations potentially distinctive pathogeneses. However, patterns in treatments specifically related to the female population previously not been studied. Methods Retrospective database analysis healthcare utilization medications prescribed for using National Ambulatory Medical Care Survey (NAMCS) data from 2002–2016 was performed. Results After age 20, accounted an...
Malignant melanoma is believed to have the highest rate of cardiac metastasis any cancer based on autopsy studies, but descriptions clinical findings, diagnosis, and treatment remain lacking. In particular, use immunotherapy has been only sparingly described. We present eight cases malignant treated at our institution. Four patients displayed symptoms, three were diagnosed routine surveillance imaging, one was postmortem. Locations tumors varied with all four chambers septum involved between...
A variety of stressors are encountered while working in the emergency department and often recreated simulation-based medical education. We seek to examine physiologic stress state response participants a simulated clinical environment commonly stressors.
Simulation use in research is often limited by controlling for scenario difficulty when using repeated measures. Our study assesses the feasibility of Modified Angoff Method to reach expert consensus regarding medical simulations. We compared scores with participant physiologic stress.Emergency medicine physicians expertise simulation education were asked review 8 scenarios and estimate percentage resident who would perform all critical actions modified method. A standard deviation (SD) less...
Abstract The development of network inference methodologies that accurately predict connectivity in dysregulated pathways may enable the rational selection patient therapies. Accurately inferring an intracellular from data remains a very challenging problem molecular systems biology. Living cells integrate extremely robust circuits exhibit significant heterogeneity, but still respond to external stimuli predictable ways. This phenomenon allows us introduce methodology integrates measurements...
The inherent role of [Ca^+jj on the shear-induced polymerization cytoskeleton was proposed by flow chamber experiments and mathematical modeling cytosolic calcium oscillations to access correlation signal transduction mechanotransduction endothelial cells. From results cells adhered fibronectin, opening characteristic membrane-bound channel assumed biphasic function exposure time shear stress. With this modification, model for IPs-induced oscillation shows a good agreement with waveforms...