A5045961101- Mechanisms of cancer metastasis
- Prostate Cancer Treatment and Research
- Advanced biosensing and bioanalysis techniques
- Biosensors and Analytical Detection
- Cancer Mechanisms and Therapy
- Microfluidic and Bio-sensing Technologies
- Silk-based biomaterials and applications
- Bone Tissue Engineering Materials
- Family and Patient Care in Intensive Care Units
- Electrospun Nanofibers in Biomedical Applications
- Pharmacological Effects and Toxicity Studies
- RNA Interference and Gene Delivery
- Estrogen and related hormone effects
- Hydrogels: synthesis, properties, applications
- Nursing Diagnosis and Documentation
- Graphene and Nanomaterials Applications
- Liver Disease Diagnosis and Treatment
- Family Caregiving in Mental Illness
- Enzyme Catalysis and Immobilization
- 3D Printing in Biomedical Research
- Pneumonia and Respiratory Infections
- Adenosine and Purinergic Signaling
- Pesticide and Herbicide Environmental Studies
- Environmental Toxicology and Ecotoxicology
- Enzyme-mediated dye degradation
All India Institute of Medical Sciences
2012-2024
Indian Institute of Technology Delhi
2021-2024
Cleveland Clinic
2023
Institute of Genomics and Integrative Biology
2019-2022
All India Institute of Medical Sciences Bhopal
2022
All India Institute of Medical Sciences Raipur
2022
Cleveland Clinic Lerner College of Medicine
2022
Himalayan University
2021
Swami Rama Himalayan University
2021
Council of Scientific and Industrial Research
2019-2020
Recent advances in woundcare is targeted towards developing active-dressings, where multiple components are combined to provide a suitable environment for rapid healing. The aim of the present research study preparation biomimic composite wound dressings by grafting hydrogel on silk fibroin fabric. swelling ability grafted fabric was optimized changing initiator concentration. In order impart antimicrobial properties, these dressing further coated sono-chemically with zinc oxide...
Antiepileptic drug therapy has significant inter-patient variability in response towards it. The current study aims to understand this at the molecular level using microarray-based analysis of peripheral blood gene expression profiles patients receiving valproate (VA) monotherapy. Only 10 unique genes were found be differentially expressed VA responders (n = 15) and 6 non-responders 8) (fold-change >2, p < 0.05). PTGS2 which encodes cyclooxygenase-2, COX-2, showed downregulation compared...
Loop-mediated isothermal amplification (LAMP) is a sensitive, efficient, and rapid nucleic acid technique resulting in large number of amplicons; however, it suffers from high incidence false positives due to carry-over aerosol. Herein, we report 10 min nano-capture system that used conjunction with modified reverse transcriptase-LAMP (RT-LAMP) assay for the accurate detection SARS CoV-2 virus. The employs in-house-designed probe-functionalized magnetic nanoparticles Co2FeAl (cobalt-based...
Abstract Mucormycosis is a rare disease with scarce diagnostic methods for early intervention. Available strategies employing direct microscopy using calcofluor white-KOH, culture, radiologic, and histopathologic testing often are time-intensive demand intricate protocols. Nucleic Acid Amplification Test holds promise due to its high sensitivity combined rapid detection. Loop-mediated isothermal amplification (LAMP) based detection offers an ultrasensitive technique that does not require...
ABSTRACT Background: Oral cancer is often preceded by oral premalignant lesions. However, most patients present at advanced stages, leading to poor quality of life (QOL). Objectives: The primary objective was assess risk factors and prevalence among security personnel. secondary focused on studying the relationship selected with correlating them prevalence. Materials Methods: A descriptive cross-sectional study conducted from June - November 2019 255 personnel AIIMS, New Delhi. Risk exposure...
Abstract Prostate cancer remains the second leading cause of death in men Western cultures. A deeper understanding mechanisms by which prostate cells divide to support tumor growth could help devise strategies overcome treatment resistance and improve survival. Here, we identified that mitotic AGC family protein kinase citron (CIT) is a pivotal regulator mediates cell interphase progression. Increased CIT expression correlated with induction aggressive progression, was overexpressed compared...
The alcohol oxidase (AOx) cDNA from Aspergillus terreus MTCC6324 with an open reading frame (ORF) of 2001 bp was constructed n-hexadecane induced cells and expressed in Escherichia coli a yield ∼4.2 mg protein g−1 wet cell. deduced amino acid sequences recombinant rAOx showed maximum structural homology the chain B aryl AOx Pleurotus eryngii. A functionally active achieved by incubating apo-AOx flavin adenine dinucleotide (FAD) for ∼80 h at 16°C pH 9.0. isoelectric point mass were found to...
Nitinol is a versatile alloy known for its shape memory effect and thus finds multiple applications in biomedical devices implants. The of nitinol-based are, however, limited because concerns related to leaching associated cytotoxicity. In particular, nitinol nanoparticles (NPs), despite being highly promising such as nano-actuators biomolecular delivery agents are not explored, owing the same concerns. Moreover, their biological interactions fully characterized, available literature on...
Effect of serum 25-hydroxy vitamin D (25[OH] D) levels on the recovery critically ill mechanically ventilated patients is unclear. Hence, this study assessed 25(OH)D mechanical ventilation at time admission to Intensive Care Unit (ICU) and its relationship with clinical outcome.In prospective observational pilot study, forty adult receiving in ICU were included. Serum was within 24 h admission. Primary outcome 30-day mortality secondary outcomes days ventilation, ICU-length stay (ICU-LOS),...
Nonviral gene delivery has seen major progress in the last two decades owing to facile synthesis, low toxicity, and ease of modification nanocarriers that take nucleic acids cells tissues. Gene nanocomplexes need reach target locations significant amounts by overcoming multiple barriers. While importance nanocomplex stability, cellular uptake, intracellular trafficking, nuclear localization been studied extensively, role retention recycling these is less understood context delivery. In this...
Lupus is an autoimmune disease that affects multiple body systems and requires long-term treatment. The multisystem effect of this long treatment may cause anxiety depression in patients with lupus nephritis (LN) ultimately deteriorate their quality life also the activity disease.This study aims to assess anxiety, depression, LN relationship activity.A descriptive cross-sectional was conducted among LN. A total enumerative technique used for recruitment 100 data collected using standardized...
Ventilator-associated pneumonia is a major source of nosocomical infection affecting about 27 percent all critically ill patients. In this study, an attempt was made to assess the effect oral decontamination with 0.2% chlorhexidine gluconate solution and hydrogen peroxide on incidence ventilator-associated oropharyngal colonisation. Seventy patients above 18 years age admitted in AIIMS, New Delhi were included as subjects. It concluded that higher given care than those chlorhexidine, which...
Hemodialysis is the most common treatment modality for patients with chronic kidney disease (CKD). Excessive daytime sleepiness and poor nighttime sleep a problem among these patients. Patients on maintenance hemodialysis (MHD) are regularly exposed to impaired fluid balance, which may cause overhydration of varying degree. However, role hydration status in quality has not been explored Indian setting. Hence, this study was undertaken assess factors affecting MHD tertiary care...
Abstract Introduction Prostate cancer (CaP) will cause the deaths of more than 34,000 American men in 2022 because systemic treatments for metastatic CaP eventually fail. There is a need actionable targets novel that work via entirely different mechanisms, bypass resistance to current therapies, and control cellular processes drive progression improve patient survival. We examine contribution citron kinase (CIT), key mediator cytokinesis, explore manner by which CIT impacts cell behavior....
Abstract Disclosure: G. Chauhan: None. V. Venkadakrishnan: U. Dahiya: Y. Ghanem: Srinivasan: B. Willard: Q. Hu: E. Cortes: S. Liu: H. Heemers: The ligand-activated androgen receptor (AR) is a transcription factor that drives prostate cancer (CaP). Blocking androgen-activation of AR via deprivation therapy (ADT) the default treatment for metastatic CaP. Despite initial remission, ADT invariably fails and CaP progresses to castration-recurrent (CRPC), which still relies on aberrantly activated...
<p>Supplementary Figure 4</p>
<p>Supplementary Figure 4</p>