A5054705249- Wound Healing and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Ocular Surface and Contact Lens
- Advancements in Transdermal Drug Delivery
- Bone Tissue Engineering Materials
- Graphene and Nanomaterials Applications
- RNA Interference and Gene Delivery
- Skin Protection and Aging
- Dermatology and Skin Diseases
- Phagocytosis and Immune Regulation
- Corneal Surgery and Treatments
- Advanced biosensing and bioanalysis techniques
- Mesenchymal stem cell research
- Antimicrobial Peptides and Activities
- Layered Double Hydroxides Synthesis and Applications
- Glycosylation and Glycoproteins Research
- Proteoglycans and glycosaminoglycans research
- Psoriasis: Treatment and Pathogenesis
- 3D Printing in Biomedical Research
- Dendrimers and Hyperbranched Polymers
- Osteoarthritis Treatment and Mechanisms
- Dental Implant Techniques and Outcomes
- Cancer Cells and Metastasis
- Antimicrobial agents and applications
- Microfluidic and Bio-sensing Technologies
NYU Langone Health
2023
Institute of Genomics and Integrative Biology
2018-2022
Academy of Scientific and Innovative Research
2018-2022
New York University
2022
Aim: The present study was aimed at determining the antiproliferative, antioxidant, anti-inflammatory and antitumor activity of developed silymarin-nanostructured lipid carrier (NLC) gel. Materials & methods: B16 melanoma cell line albino mice were used as ex vivo in models, respectively, to evaluate aforementioned pharmacological activities. Results: volume large tumors significantly (p < 0.05) reduced from 5.02 3.05 mm3, levels IL-1α TNF-α 0.001) lower superoxide dismutase (SOD), catalase...
Hydrogel-mediated topical delivery of betamethasone effectively mitigates psoriasis.
In recognition of the potential calreticulin (CRT) protein in enhancing rate and quality wound healing excisional animal models, this study was to incorporate CRT via polyblend electrospinning into polycaprolactone (PCL)/type 1 collagen (Col1) nanofibers (NFs; 334 ± 75 nm diameter) as biomimetic extracellular matrices provide a novel mode delivery protection with enhanced synergistic activities for tissue regeneration. Release kinetic studies using fluoresceinated (CRT-FITC) NFs showed burst...
In this article, we describe a method of delivery chondroitin sulfate to skin as nanoparticles and demonstrate its anti-inflammatory antioxidant role using UV irradiation model condition. These nanoparticles, formed through electrostatic interactions with skin-penetrating peptide, were found be homogenous positive surface charges stable at physiological acidic pH under certain conditions. They able enter into the human keratinocyte cell line (HaCaT), artificial membrane (mimicking skin),...
Treatment of chronic wound infections caused by Gram-positive bacteria such as Staphylococcus aureus is highly challenging due to the low efficacy existing formulations, thereby leading drug resistance. Herein, we present synthesis a nonimmunogenic cholic acid–glycine–glycine conjugate (A6) that self-assembles into supramolecular viscoelastic hydrogel (A6 gel) suitable for topical applications. The A6 can entrap different antibiotics with high without compromising its behavior. Activities...
Nonviral gene delivery has seen major progress in the last two decades owing to facile synthesis, low toxicity, and ease of modification nanocarriers that take nucleic acids cells tissues. Gene nanocomplexes need reach target locations significant amounts by overcoming multiple barriers. While importance nanocomplex stability, cellular uptake, intracellular trafficking, nuclear localization been studied extensively, role retention recycling these is less understood context delivery. In this...
Abstract Ultrafine fibers and a bioactive glass mineralized fibrous mat of gelatin‐pectin blends were produced by electrospinning in an aqueous phase. Herein, the blend was used as template for situ mineralization particles during based hybrid composite fiber matrix. Further, along with functioned site 7‐dehydrocholesterol, i. e., vitamin‐D precursor. This engineered resulted sustained release drug, which is necessary strengthening neo regenerated bones. The also exhibited excellent...
Glycosaminoglycans, both cell-surface and exogenous, can interfere with DNA delivery efficiency of nonviral carrier systems. In this work, we report an extensive comparative study to explore the effect exogenously added chondroitin sulfate on biophysical characteristics, cellular uptake, transfection efficiency, intracellular trafficking nanocomplexes formed using primary secondary amphipathic peptides developed in our laboratory. Our results indicate that presence exogenous exhibits...
The processes involved in regeneration of cutaneous compared to corneal tissues involve different intrinsic mechanisms. Importantly, wounds healing by angiogenesis but vascularization the cornea obscures vision. Previous studies showed that topically applied calreticulin (CALR) healed full-thickness excisional animal a tissue regenerative process markedly enhancing repair without evoking angiogenesis. In current study, application CALR rabbit injury model: (1) accelerated full wound closure...