Gaura Chaturvedi
A5067603143- RNA Research and Splicing
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- SARS-CoV-2 detection and testing
- Traditional Chinese Medicine Studies
- COVID-19 epidemiological studies
- RNA modifications and cancer
- Gut microbiota and health
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Plant-based Medicinal Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Metabolomics and Mass Spectrometry Studies
- Oral Health Pathology and Treatment
- RNA and protein synthesis mechanisms
Institute of Genomics and Integrative Biology
2019-2022
Academy of Scientific and Innovative Research
2019-2022
Studying respiratory illness-specific microbial signatures and their interaction with other micro-residents could provide a better understanding of lung ecology. Each illness has specific disease etiology, however, so far no study revealed disease-specific markers. The present was designed to determine features interactions residents in chronic obstructive pulmonary diseases (stable exacerbated), sarcoidosis, interstitial diseases. Broncho-alveolar lavage samples (n = 43) were analyzed by...
To understand the spread of SARS-CoV2, in August and September 2020, Council Scientific Industrial Research (India) conducted a serosurvey across its constituent laboratories centers India. Of 10,427 volunteers, 1058 (10.14%) tested positive for SARS-CoV2 anti-nucleocapsid (anti-NC) antibodies, 95% which had surrogate neutralization activity. Three-fourth these recalled no symptoms. Repeat serology tests at 3 (n = 607) 6 175) months showed stable anti-NC antibodies but declining Local...
Precision medicine aims to move from traditional reactive a system where risk groups can be identified before the disease occurs. However, phenotypic heterogeneity amongst diseased and healthy poses major challenge for identification markers stratification early actionable interventions. In Ayurveda, individuals are phenotypically stratified into seven constitution types based on multisystem phenotypes termed "Prakriti". It enables prediction of health trajectories selection We hypothesize...
Abstract Personalized medicine relies on successful identification of genome-wide variations that governs inter-individual differences in phenotypes and system level outcomes. In Ayurveda, assessment composite constitution types “ Prakriti” forms the basis for risk stratification, predicting health disease trajectories personalized recommendations. Here, we report a novel method identifying pleiotropic genes variants associate with healthy individuals three extreme contrasting constitutions...
Alu repeats contribute to phylogenetic novelties in conserved regulatory networks primates. Our study highlights how exonized Alus could nucleate large-scale mRNA-miRNA interactions. Using a functional genomics approach, we characterize transcript isoform of an orphan gene, CYP20A1 (CYP20A1_Alu-LT) that has exonization 23 its 3'UTR. CYP20A1_Alu-LT, confirmed by 3'RACE, is outlier length (9 kb 3'UTR) and widely expressed. publically available data sets, demonstrate expression higher primates...
Summary To understand the spread of SARS-CoV2, in August and September 2020, Council Scientific Industrial Research (India), conducted a sero-survey across its constituent laboratories centers India. Of 10,427 volunteers, 1058 (10.14%) tested positive for SARS CoV2 anti-nucleocapsid (anti-NC) antibodies; 95% with surrogate neutralization activity. Three-fourth recalled no symptoms. Repeat serology tests at 3 (n=346) 6 (n=35) months confirmed stability antibody response potential. Local...
Abstract Background Primate-specific Alus contribute to transcriptional novelties in conserved gene regulatory networks. Alu RNAs are present at elevated levels stress conditions and consequently leads transcript isoform specific functional role modulating the physiological outcome. One of possible mechanisms could be nucleated mRNA-miRNA interplay. Result Using combination bioinformatics experiments, we report a an orphan gene, CYP20A1 ( CYP20A1_Alu-LT ) through exaptation 23 its 9kb 3’UTR....
Abstract Background: Primate-specific Alus contribute to transcriptional novelties in conserved gene regulatory networks. Alu RNAs are present at elevated levels stress conditions and consequently leads transcript isoform specific functional role modulating the physiological outcome. One of possible mechanisms could be nucleated mRNA-miRNA interplay. Result: Using combination bioinformatics experiments, we report a an orphan gene, CYP20A1 ( CYP20A1_Alu-LT ) through exaptation 23 its 9kb...
Abstract Background: Alu repeats contribute to phylogenetic novelties in conserved regulatory networks primates. Exaptation of Alus transcript isoforms could nucleate large-scale mRNA-miRNA interactions and modulate cellular outcomes. Result: Using a functional genomics approach, we report isoform an orphan gene, CYP20A1 (CYP20A1_Alu-LT) that arise through exonization 23 3’UTR is expressed higher CYP20A1_Alu-LT, confirmed by 3’RACE, outlier length (9kb) multiple cell lines. We demonstrate...
Abstract Background: Alu repeats contribute to phylogenetic novelties in conserved regulatory networks primates. Exaptation of Alus transcript isoforms could nucleate large-scale mRNA-miRNA interactions and modulate cellular outcomes. Result: Using a functional genomics approach, we report isoform an orphan gene, CYP20A1 (CYP20A1_Alu-LT) that arise through exonization 23 3’UTR is expressed higher CYP20A1_Alu-LT, confirmed by 3’RACE, outlier length (9kb) multiple cell lines. publicly...