A5049663485- Gut microbiota and health
- Probiotics and Fermented Foods
- Clostridium difficile and Clostridium perfringens research
- Nanoparticles: synthesis and applications
- Advanced Photocatalysis Techniques
- Microbial Community Ecology and Physiology
- Plant-Microbe Interactions and Immunity
- Diet and metabolism studies
- TiO2 Photocatalysis and Solar Cells
- Genomics and Phylogenetic Studies
- Legume Nitrogen Fixing Symbiosis
- Metabolomics and Mass Spectrometry Studies
- Arsenic contamination and mitigation
- Microbial Metabolites in Food Biotechnology
- Advanced Nanomaterials in Catalysis
- Microbial Metabolic Engineering and Bioproduction
- Infections and bacterial resistance
- Enzyme Catalysis and Immobilization
- Antibiotic Resistance in Bacteria
- Electrochemical sensors and biosensors
- SARS-CoV-2 detection and testing
- Gas Sensing Nanomaterials and Sensors
- Biosensors and Analytical Detection
- Celiac Disease Research and Management
- Nanomaterials for catalytic reactions
Maharshi Dayanand University
2015-2024
Institute of Genomics and Integrative Biology
2008-2017
Council of Scientific and Industrial Research
2008-2017
Savitribai Phule Pune University
2008
Osmotolerance is one of the critical factors for successful survival and colonization microbes in saline environments. Nonetheless, information about these osmotolerance mechanisms still inadequate. Exploration soil microbiome its community structure novel genetic elements likely to provide on involved osmoadaptation. The present study explores native 16S rRNA gene sequence analysis has indicated dominance halophilic/halotolerant phylotypes affiliated Proteobacteria, Actinobacteria,...
Heterogeneity amidst healthy individuals at genomic level is being widely acknowledged. This, in turn, modulated by differential response to environmental cues and treatment regimens, necessitating the need for stratified/personalized therapy. We intend understand molecular determinants of Ayurvedic way (ancient Indian system medicine) endo-phenotyping into distinct constitution types termed "Prakriti", which forms basis personalized treatment. In this study, we explored analyzed human gut...
Studying respiratory illness-specific microbial signatures and their interaction with other micro-residents could provide a better understanding of lung ecology. Each illness has specific disease etiology, however, so far no study revealed disease-specific markers. The present was designed to determine features interactions residents in chronic obstructive pulmonary diseases (stable exacerbated), sarcoidosis, interstitial diseases. Broncho-alveolar lavage samples (n = 43) were analyzed by...
Introduction Microbial biofertilizers or biocontrol agents are potential sustainable approaches to overcome the limitations of conventional agricultural practice. However, limited catalog microbial candidates for diversified crops creates hurdles in successfully implementing agriculture increasing global/local populations. The present study aimed explore wheat rhizosphere microbiota strains with a biofertilizer and potential. Methods Using culturing-based approach, 12 unique isolates were...
Abstract A new series of quinoline based aurones 7(a–n) has been synthesized and evaluated for their antibacterial, antifungal antiquorum sensing activities. These novel have prepared directly from 2‐chloro‐1‐(2,4‐dihydroxyphenyl)ethan‐1‐one in one pot, by reacting it with differently substituted 2‐chloroquinoline‐3‐carbaldehydes using activated barium hydroxide under solvent free grinding conditions. Structures these are agreement IR, 1 H‐NMR, 13 C‐NMR HRMS data. Some compounds attributed a...
Sodium benzoate is one of the widely used food preservatives and its metabolism in human body has been studied only with host perspective. Despite gut microbiome being considered as a virtual organ, role yet to be elucidated. The current study uses multi-omic approach rationalize microbes metabolism. Microbial diversity analysis multiple features synchronously indicates dominance Bacteroidetes followed by Firmicutes, Actinobacteria, Proteobacteria. Metagenomic exploration highlights presence...
The global COVID-19 pandemic continues due to emerging Severe Acute Respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOC). Here, we performed comprehensive analysis in-house sequenced SARS-CoV-2 genome mutations dynamics in the patients infected with VOCs - Delta and Omicron, within Recovered Mortality patients. Statistical highlighted significant T4685A, N4992N, G5063S RdRp; T19R NTD spike; K444N N532H RBD spike, associated mortality. Mutations, T19I Q493R N440K spike...
Abstract Aims This study aimed to isolate plant growth and drought tolerance-promoting bacteria from the nutrient-poor rhizosphere soil of Thar desert plants unravel their molecular mechanisms promotion. Methods results Among our rhizobacterial isolates, Enterobacter cloacae C1P-IITJ, Kalamiella piersonii J4-IITJ, Peribacillus frigoritolerans T7-IITJ, significantly enhanced root shoot (4˗5-fold) in Arabidopsis thaliana under PEG-induced stress. Whole genome sequencing biochemical analyses...
The majority of bacteria elude culture in the laboratory. A metagenomic approach provides culture-independent access to gene pool whole bacterial community. library was constructed from an industrial effluent treatment plant sludge containing about 1.25 Gb microbial community DNA. Two arsenic-resistant clones were selected library. Clones MT3 and MT6 had eight- 18-fold higher resistance sodium arsenate comparison with parent strain, respectively. also showed increased arsenite but not...
Microbes are ubiquitously distributed in nature, and recent culture-independent studies have highlighted the significance of gut microbiota human health disease. Fecal DNA is primary source for majority microbiome studies. However, further improvement needed to obtain fecal metagenomic with sufficient amount good quality but low host genomic contamination. In current study, we demonstrate a quick, robust, unbiased, cost-effective method isolation high molecular weight (>23kb) (260/280 ratio...
Vanillin is a phenolic food additive commonly used for flavor, antimicrobial, and antioxidant properties. Though it one of the widely additives, strategies human gut microbes to evade its antimicrobial activity await extensive elucidation. The current study explores microbiome with multi-omics approach elucidate composition metabolic machinery counter vanillin bioactivity. A combination SSU rRNA gene diversity, metagenomic RNA features phylogenetic affiliation metagenome encoded proteins,...