A5062294948- Epigenetics and DNA Methylation
- Sperm and Testicular Function
- Reproductive Biology and Fertility
- Genomics and Chromatin Dynamics
- Cancer-related gene regulation
- Folate and B Vitamins Research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Renal and related cancers
- Pharmaceutical Practices and Patient Outcomes
- Healthcare Systems and Reforms
- Genetics and Neurodevelopmental Disorders
- Gout, Hyperuricemia, Uric Acid
- Antibiotics Pharmacokinetics and Efficacy
- Agricultural risk and resilience
- Urinary Tract Infections Management
- Genetic Syndromes and Imprinting
- Veterinary medicine and infectious diseases
- Pharmacogenetics and Drug Metabolism
- Renin-Angiotensin System Studies
- Suicide and Self-Harm Studies
- Hormonal and reproductive studies
- Antiplatelet Therapy and Cardiovascular Diseases
- Ocular Infections and Treatments
- Male Breast Health Studies
- SARS-CoV-2 and COVID-19 Research
University of California, Santa Barbara
2023-2024
Central Drug Research Institute
2013-2022
Midnapore Medical College and Hospital
2022
R. G. Kar Medical College and Hospital
1976-2016
Council for Scientific and Industrial Research
2013
Mahindra Group (India)
1990
Do methylation changes in sperm DNA correlate with infertility? Loss of spermatogenesis and fertility was correlated 1680 differentially-methylated CpGs (DMCs) across 1052 genes. Methylation a number genes have been reduced count motility. This case-control study used spermatozoal from 38 oligo-/oligoastheno-zoospermic infertile patients 26 normozoospermic fertile men. Genome-wide analysis undertaken using 450 K BeadChip on six men to identify DMCs. followed by deep sequencing 32 20...
The Ayurvedic medicinal system claims Mucuna pruriens (MP) to possess pro-male fertility, aphrodisiac and adaptogenic properties. Some scientific evidence also supports its fertility properties; however, the mechanism of action is not yet clear. present study aimed at demonstrating spermatogenic restorative efficacy MP major constituent L-DOPA (LD), finding possible thereof in a rat model.Ethinyl estradiol (EE) was administered rate 3 mg/kg body weight (BW)/day for period 14 days generate...
Aim: In this study, the goal was to asses Drug utilization evaluation, WHO core indicators, monitoring patient’s response therapy of coronary artery disease. Study Design: Sapthagiri institute medical sciences, Bangalore. Place and Duration Study: Sample: Department Cardiology Institute Medical Sciences (SIMS), From (June 2024- Nov 2024) Chikkasandra, Hesaraghatta Road Methodology: We conducted prospective cross-sectional study for 6 months which includes patients who were diagnosed with...
Estrogen Receptor-β (ER-β), a tumor-suppressor in prostate cancer, is epigenetically repressed by hypermethylation of its promoter. DNA-methyltransferases (DNMTs), which catalyze the transfer methyl-groups to CpG islands gene promoters, are overactive cancers and can be inhibited DNMT-inhibitors re-express tumor suppressors. The FDA-approved nucleoside like 5-Azacytidine 5-Aza-deoxycytidine carry notable concerns due their off-target toxicity, therefore non-nucleoside DNMT inhibitors...
The authors made a field-survey of mental morbidity in all the tribal and caste groups residing cluster villages West Bengal, India, found that, each group, higher socio-economic classes had rates morbidity. Different having similar cultural pattern showed no significant difference their Groups different patterns differed significantly In some neurotic disorders were absent.
A psychiatric field‐survey was conducted in three villages West Bengal, India order to correlate the prevalence of mental morbidity with socio‐economic status families. The sample divided into four groups on basis religion or caste. Total had no statistically significant relationship any groups. In total it directly related. Higher classes significantly higher rates. Psychoses were not correlated Neuroses showed a rate upper strata two groups; other trend same direction. differences their...
Summary Those who were labelled as depressives in a rural survey randomly divided into Medicine group (who received antidepressive drug treatment), Placebo placebo) and Natural Process no treatment). The depth of their depression was assessed by Hamilton's Depressive Rating Scale before the beginning trial, on 14th day 28th trial. They compared with matched healthy controls again attended an urban clinic for treatment. results indicate that never sought treatment voluntarily not different...
<b>Aims:</b> This study compared the effectiveness of prophylactic administration topical flurbiprofen 0.03% and nepafenac 0.1% in maintaining mydriasis during small incision cataract surgery (SICS).<br><b>Materials Methods:</b> was a prospective, randomized, double-blind comparative adult patients given or prior to SICS capsular bag intraocular lens (IOL) implantation at tertiary care hospital. Horizontal vertical diameters pupil were measured beginning end surgery, mean values across two...
Androgens in breast cancer have been studied alone and correlation with estrogens as estrogen to testosterone ratio. 5-α-reductase is one of the important enzymes participating androgen metabolism, which affects activity by affecting conversion dihydrotestosterone. We hypothesized that polymorphisms SRD5A2 gene (encoding 5-α-reductase) may affect risk total activity. Complete coding region was sequenced a group 628 patients 244 control samples from three southern states (Tamil Nadu, Andhra...
The aim of this study was to investigate the association 24 functionally important single nucleotide polymorphisms (SNPs) with male infertility. In cross-sectional study, we genotyped in infertility candidate genes 500 oligo-/astheno-/oligoastheno-/normo-zoospermic infertile men idiopathic Sequenom iPlex gold assay used for genotyping. Sperm count and motility were compared between prevalent genotypes at each test locus. We did not observe any significant difference average sperm alternate...
This study aimed at investigating if M235T polymorphism in the AGT gene and A/G(I8-83) REN correlate with end-stage renal disease (ESRD).We analyzed 173 ESRD patients 329 individuals normal kidney function for differences genotype distribution of AGT-M235T REN-A/G(I8-83) polymorphisms between two groups. The data cases controls were compared using χ(2) test.We found significantly higher levels serum creatinine CRP comparison to (p < 0.0001). Data showed a significant association substitution...
Transmission of 5-methylcytosine (5mC) from one cell generation to the next plays a key role in regulating cellular identity mammalian development and diseases. While recent work has shown that activity DNMT1, protein responsible for stable inheritance 5mC mother daughter cells, is imprecise; it remains unclear how fidelity DNMT1 tuned different genomic state contexts. Here we describe Dyad-seq, method combines enzymatic detection modified cytosines with nucleobase conversion techniques...
Outcome of infection with Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) may depend on the host, virus or host-virus interaction related factors. Complete SARS-CoV-2 genome was sequenced using Illumina and Nanopore platforms from naso-/oro-pharyngeal ri-bonucleic acid (RNA) specimens COVID-19 patients varying severity outcomes, including mild upper respiratory symptoms (n=35), severe disease admitted to intensive care gastrointestinal (n=21), fatal outcome (n=17) asymptomatic...
BACKGROUNDIn urinary tract infection, levofloxacin is used to treat both complicated and uncomplicated cases.To reduce the pain burning sensation in lower UTI, physicians commonly prescribe an alkaliniser like disodium hydrogen citrate along with levofloxacin.The combined effect of these two drugs unknown.Aim our study was find out alkalinisation urine on efficacy infection.Study Design-The conducted at general screening outpatient department R. G. Kar Medical College Hospital.The a...