A5073399728- Metal complexes synthesis and properties
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Sperm and Testicular Function
- Magnetism in coordination complexes
- Metal-Catalyzed Oxygenation Mechanisms
- Prostate Cancer Treatment and Research
- Natural Antidiabetic Agents Studies
- DNA and Nucleic Acid Chemistry
- Folate and B Vitamins Research
- Oral microbiology and periodontitis research
- Dental Health and Care Utilization
- Radiopharmaceutical Chemistry and Applications
- Inorganic and Organometallic Chemistry
- Sexual Differentiation and Disorders
- Birth, Development, and Health
- Hormonal and reproductive studies
- Lanthanide and Transition Metal Complexes
- Prostate Cancer Diagnosis and Treatment
- Biochemical and biochemical processes
- Bioactive Natural Diterpenoids Research
- Cassava research and cyanide
- Molecular Sensors and Ion Detection
- Dental Research and COVID-19
- Radioactive element chemistry and processing
- Reproductive Biology and Fertility
Wageningen University & Research
2025
Asian Development Bank Institute
2024
The NorthCap University
2023-2024
Centre for Aromatic Plants
2024
Central Drug Research Institute
2008-2022
Dr. A.P.J. Abdul Kalam Technical University
2021
Aditya Birla (India)
2015
Government Dental College & Research Institute
2015
Memorial
2014
Council of Scientific and Industrial Research
2011-2012
BackgroundAbiraterone acetate plus prednisolone (herein referred to as abiraterone) or enzalutamide added at the start of androgen deprivation therapy improves outcomes for patients with metastatic prostate cancer. Here, we aimed evaluate long-term and test whether combining abiraterone survival.MethodsWe analysed two open-label, randomised, controlled, phase 3 trials STAMPEDE platform protocol, no overlapping controls, conducted 117 sites in UK Switzerland. Eligible (no age restriction) had...
Background It was believed earlier that spermatozoa have no traces of RNA because loss most the cytoplasm. Recent studies revealed presence about 3000 different kinds mRNAs in ejaculated spermatozoa. However, correlation transcriptome profile with infertility remains obscure. Methods Total from sperm (after exclusion somatic cells) 60 men consisting individuals known fertility (n=20), idiopathic (normozoospermic patients, n=20), and asthenozoospermia (n=20) isolated. After quality check on...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and properties of new DNA cleavage agents based on oxoruthenium(IV)Nishi Gupta, Neena Grover, Gregory A. Neyhart, Phirtu Singh, H. Holden ThorpCite this: Inorg. Chem. 1993, 32, 3, 310–316Publication Date (Print):February 1, 1993Publication History Published online1 May 2002Published inissue 1 February 1993https://pubs.acs.org/doi/10.1021/ic00055a014https://doi.org/10.1021/ic00055a014research-articleACS PublicationsRequest reuse...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStudies of electrocatalytic DNA cleavage by oxoruthenium(IV). X-ray crystal structure [Ru(tpy)(tmen)OH2](ClO4)2 (tmen = N,N,N',N'-tetramethylethylenediamine, tpy 2,2',2''-terpyridine)Neena Grover, Nishi Gupta, Phirtu Singh, and H. Holden ThorpCite this: Inorg. Chem. 1992, 31, 11, 2014–2020Publication Date (Print):May 1, 1992Publication History Published online1 May 2002Published inissue 1...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStereoselective covalent binding of aquaruthenium(II) complexes to DNANeena Grover, Nishi Gupta, and H. Holden ThorpCite this: J. Am. Chem. Soc. 1992, 114, 9, 3390–3393Publication Date (Print):April 1, 1992Publication History Published online1 May 2002Published inissue 1 April 1992https://pubs.acs.org/doi/10.1021/ja00035a034https://doi.org/10.1021/ja00035a034research-articleACS PublicationsRequest reuse permissionsArticle...
This study explored the safety and antidiabetic potential of a hydroalcoholic extract Praecitrullus fistulosus fruits, along with qualitative quantitative phytochemical analyses. The effect was evaluated using in vitro methods, including α-amylase α-glucosidase inhibition assays, as well an vivo high-fat diet low-dose streptozotocin-induced diabetic model. Molecular docking studies were conducted to identify phytochemicals responsible for effects. fruit exhibited maximum 52.06% 58.10%...
Single-domain antibody fragments (VHHs) binding specific antigens are often isolated by llama immunization and phage display selection. We determined the optimal blood sampling time for generating libraries with a high frequency of antigen-binding VHHs. Two llamas were immunized 7 antigens. Blood samples collected 2-3 day interval up to 11 days post used deep sequencing selection The VHH clones was identification unique sequences in sequenced libraries. On average, highest clone found...
A RuIVO functional unit and an intercalating heteroligand, dipyridophenazine (dppz), are united in the complex cation of title, 1, responsible for its high DNA-cleavage activity DNA affinity. In solid state, units RuOH2 analogue 1 (C1O counterion) linked by π-stacking interactions similar to those acridine orange other conventional intercalators; distance between dppz ligands is 3.5 Å. tpy = 2,2′,2″-terpyridine.
Natural products play an important role in drug discovery and many approved therapeutics as well candidates has been derived from natural sources. They have the source of most active ingredients medicines. The beneficial medicinal effects plant materials typically result combinations secondary present plan. These metabolites constitute value a plant, which produces definite physiological action on human body. Euphorbia tirucalli belongs to family- Euphorbiaceae is commonly known...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTriply bridged diruthenium complexes with [RuIII2(.mu.-O)(.mu.-O2CCH3)2]2+ and [RuIVRuIII(.mu.-O)(.mu.-O2CCH3)2]3+ cores: synthesis, spectra, electrochemistryNishi Gupta, Subhasish Mukerjee, Samiran Mahapatra, Manabendra Ray, Rabindranath MukherjeeCite this: Inorg. Chem. 1992, 31, 1, 139–141Publication Date (Print):January 1992Publication History Published online1 May 2002Published inissue 1 January 1992https://doi.org/10.1021/ic00027a027Request...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRecombinant Desulfovibrio vulgaris rubrerythrin. Isolation and characterization of the diiron domainNishi Gupta, Francesco Bonomi, Donald M. Kurtz, Jr., Natarajan Ravi, Dan Li Wang, Boi Hanh HuynhCite this: Biochemistry 1995, 34, 10, 3310–3318Publication Date (Print):March 1, 1995Publication History Published online1 May 2002Published inissue 1 March...
The effect of methyl substituents adjacent to donor atoms on the complexing properties a novel family tridentate (N3) heterocyclic ligands has been explored. In course this investigation new group high-spin iron(II) complexes synthesised. characterization in solution FeIIN6 co-ordination done basis paramagnetically shifted 1H NMR spectroscopy. Increased steric crowding progressively decreases values 10 Dq for these with and nickel(II) grossly octahedral complexes. also display...
Prostate specific antigen (PSA/KLK3) is known to be the chief executor of fragmentation semenogelins, dissolution semen coagulum, thereby releasing sperm for active motility. Recent research has found that semenogelins also play significant roles in fertility by affecting hyaluronidase activity, capacitation and motility, making PSA important beyond simple liquefaction. level been shown correlate with suggesting level/activity can affect fertility. However, no study investigating genetic...
Abstract Purpose: To examine whether carbogen and nicotinamide increases 5-fluorouracil (5-FU) delivery to colorectal cancer metastases. Experimental Design: Six patients were scanned using positron emission tomography. Two scans done coincide with the start of separate chemotherapy cycles. At second tomography session, 60 mg/kg was given orally 2 3 hours before 10-minute inhalation. In middle treatment, [15O]H2O (to measure regional tissue perfusion) then [18F]5-FU 5-FU pharmacokinetics)...
The diferrous oxidation level of carboxylate-bridged non-heme diiron proteins is pivotal because only it reacts directly with dioxygen. In this state each ferrous ion has ST = 2. Such integer-spin, so-called "Non-Kramers" (NK) systems typically are difficult to access by paramagnetic resonance techniques, and property precluded the application ENDOR ESEEM spectroscopies state. Integer-spin frequently exhibit a ground "Non-Kramers doublet", however, which split in zero applied field an energy...
To generate a recombinant Mycobacterium aurum strain for screening of antimycobacterial compounds affecting fatty acid synthase type II (FAS-II) elongation pathway.kas operon locus was delineated in M. aurum, fast growing nonpathogenic strain. Cloning and sequencing all the genes showed similar organization sequence similarities with tuberculosis (H37Rv) orthologues. Further, we cloned upstream region kas fusion lacZ reporter gene put it aurum. Recombinant continued expression throughout...