A5084309885- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- T-cell and B-cell Immunology
- CAR-T cell therapy research
- Immune cells in cancer
- Endoplasmic Reticulum Stress and Disease
- Ubiquitin and proteasome pathways
- Hematopoietic Stem Cell Transplantation
- Cell death mechanisms and regulation
- Mechanisms of cancer metastasis
- Neuropeptides and Animal Physiology
- Parasite Biology and Host Interactions
- Global Maternal and Child Health
- Heat shock proteins research
- Monoclonal and Polyclonal Antibodies Research
- Signaling Pathways in Disease
- Bioactive Compounds and Antitumor Agents
- Parasites and Host Interactions
- Autophagy in Disease and Therapy
Rega Institute for Medical Research
2019-2022
KU Leuven
2019-2022
Vrije Universiteit Brussel
2011
Air Force Medical University
2010
MRC Laboratory of Molecular Biology
2009
State Key Laboratory of Cancer Biology
2009
National Institute of Malariology, Parasitology and Entomology
2005
Abstract HAb18G/CD147, a glycoprotein of the immunoglobulin super‐family (IgSF), is T cell activation‐associated molecule. In this report, we demonstrated that HAb18G/CD147 expression on both activated CD4 + and CD8 cells was up‐regulated. vitro cross‐linking with an anti‐HAb18G/CD147 monoclonal antibody (mAb) 5A12 inhibited proliferation upon receptor stimulation. Such co‐stimulation by down‐regulating CD25 interleukin‐2 (IL‐2), decreased production IL‐4 but not interferon‐γ. Laser confocal...
The role of the humoral immune system in human infection with Ascaris lumbricoides remains unclear. This study documents an epidemiological investigation a highly endemic community Vietnam, whereby serum antibody levels were assessed before treatment and after 6-month reinfection period. These data examined by correlation status using age-structured approach attempt to help shed light on response. first part this characterized all isotypes from response antigens both adult larval A....
AbstractTo study the expression of N-myc Downstream Regulated Gene-2 (NDRG2) in prostatic carcinoma (PCA) tissue and different PCA cell lines, to investigate its clinical pathological implications, 144 benign hyperplasia (BPH) sections were analyzed retrospectively with immunohistochemistry (S-P method). The levels NDRG2 c-Myc prostate lines detected through Western blot. effects adenovirus-mediated on PC3 cells nude mouse xenografts was observed growth curves, tumor flow cytometry (FCM),...
Optimal T-cell activation requires both an antigen-specific and a costimulatory signal. CD167 is tyrosine kinase receptor for native type I collagen, its physiologic functions include matrix homeostasis cell growth, adhesion, branching, migration, but the specific role of in T cells has not yet been characterized. In this study, we found that expression on was up-regulated after activation. Cooperation engagement with suboptimal TCR/CD3 signals induced proliferation, enhanced markers such as...
Growth of solid tumors is often associated with the development an immunosuppressive tumor microenvironment (TME). It has been suggested that influence TME may extend beyond local and results in systemic immunosuppression. Here, we utilize two murine cancer models to explore on occurrence alloreactivity-driven GvHD graft-versus-solid (GvT) effects following MHC-mismatched allogeneic bone marrow transplantation (allo-BMT). Melanoma- or colon carcinoma-bearing C57BL/6 mice did not develop...
Clinical benefits obtained from checkpoint blockade regimens demonstrate the importance of overcoming immunosuppressive tumour microenvironment (TME) in cancer immunotherapy. Intravenous (i.v.) injection B16 melanoma cells (H-2Kb) leads to lethal disseminated pulmonary metastasis Balb/c recipients (H-2Kd). This lack immune control is related low major histocompatibility complex (MHC) expression on which associated with delayed and decreased anti-tumour adaptive responses (e.g., alloantibody...
Abstract Natural killer (NK) cells provide a natural defense against MHC-I–negative tumors, such as melanoma. Donor lymphocyte infusion (DLI) containing NK cells, form of adoptive immunotherapy used after allogenic bone marrow transplantation (allo-BMT), promotes antitumor immune responses but is often associated with life-threatening complications graft-versus-host disease (GvHD). Here, we showed that without prior allo-BMT, DLI provoked melanoma control the infiltration and persistence...
<div>Abstract<p>Growth of solid tumors is often associated with the development an immunosuppressive tumor microenvironment (TME). It has been suggested that influence TME may extend beyond local and results in systemic immunosuppression. Here, we utilize two murine cancer models to explore on occurrence alloreactivity-driven GvHD graft-versus-solid (GvT) effects following MHC-mismatched allogeneic bone marrow transplantation (allo-BMT). Melanoma- or colon carcinoma–bearing...
<div>Abstract<p>Growth of solid tumors is often associated with the development an immunosuppressive tumor microenvironment (TME). It has been suggested that influence TME may extend beyond local and results in systemic immunosuppression. Here, we utilize two murine cancer models to explore on occurrence alloreactivity-driven GvHD graft-versus-solid (GvT) effects following MHC-mismatched allogeneic bone marrow transplantation (allo-BMT). Melanoma- or colon carcinoma–bearing...
<p>Figure S1. Treg cells accumulate at multiple organs in tumor-bearing mice. Figure S2. allo-BMT leads to aGVHD. S3. post-BMT. S4. Efficiency of depletion. S5. thymectomy B6 S6. T cell add-back abrogates the GVT effect TCD transplant. S7. Macrophage loss impact on GVT. S8. M1 polarization disrupts expansion.</p>
<p>Figure S1. Treg cells accumulate at multiple organs in tumor-bearing mice. Figure S2. allo-BMT leads to aGVHD. S3. post-BMT. S4. Efficiency of depletion. S5. thymectomy B6 S6. T cell add-back abrogates the GVT effect TCD transplant. S7. Macrophage loss impact on GVT. S8. M1 polarization disrupts expansion.</p>
<div>Abstract<p>Natural killer (NK) cells provide a natural defense against MHC-I–negative tumors, such as melanoma. Donor lymphocyte infusion (DLI) containing NK cells, form of adoptive immunotherapy used after allogenic bone marrow transplantation (allo-BMT), promotes antitumor immune responses but is often associated with life-threatening complications graft-versus-host disease (GvHD). Here, we showed that without prior allo-BMT, DLI provoked melanoma control the infiltration...
<div>Abstract<p>Natural killer (NK) cells provide a natural defense against MHC-I–negative tumors, such as melanoma. Donor lymphocyte infusion (DLI) containing NK cells, form of adoptive immunotherapy used after allogenic bone marrow transplantation (allo-BMT), promotes antitumor immune responses but is often associated with life-threatening complications graft-versus-host disease (GvHD). Here, we showed that without prior allo-BMT, DLI provoked melanoma control the infiltration...
<p>Figure S1. Evaluation of immune cells in host mice. Figure S2. donor T and NK reconstitution. S3. Melanoma-bearing mice are protected from lethal GVHD after DLI. S4. MHC-I expression on different B16 cells. S5. before transfer. S6. Maturation S7. Donor DCs maturation.</p>
<p>Figure S1. Evaluation of immune cells in host mice. Figure S2. donor T and NK reconstitution. S3. Melanoma-bearing mice are protected from lethal GVHD after DLI. S4. MHC-I expression on different B16 cells. S5. before transfer. S6. Maturation S7. Donor DCs maturation.</p>