A5102974731- Acute Myeloid Leukemia Research
- Cystic Fibrosis Research Advances
- Protein Degradation and Inhibitors
- Inhalation and Respiratory Drug Delivery
- RNA Interference and Gene Delivery
- Immunotherapy and Immune Responses
- Epigenetics and DNA Methylation
- Lipid metabolism and disorders
- Chronic Lymphocytic Leukemia Research
- Neonatal Respiratory Health Research
- Asthma and respiratory diseases
- Vascular Tumors and Angiosarcomas
- Immune cells in cancer
- Histone Deacetylase Inhibitors Research
- Monoclonal and Polyclonal Antibodies Research
- Retinoids in leukemia and cellular processes
- Allergic Rhinitis and Sensitization
- Advanced biosensing and bioanalysis techniques
- Cancer-related molecular mechanisms research
- Orthopedic Infections and Treatments
University of Pennsylvania
2025
Shanghai Institute of Nutrition and Health
2018-2024
Shanghai Institutes for Biological Sciences
2018-2024
Mirna Therapeutics (United States)
2024
Soochow University
2024
University of North Carolina at Chapel Hill
2011-2023
University of Washington
2023
Lung Institute
2023
Center for Environmental Health
2015
Beijing Institute of Genomics
2013
Inhalation of hypertonic saline (HS) acutely enhances mucociliary clearance (MC) in both health and disease. In patients with cystic fibrosis (CF), repeated use HS causes a sustained improvement MC as well clinical benefit. The pharmacodynamic duration activity on may be an important determinant its therapeutic potential other airways diseases. Before moving toward testing the benefits for non-CF indications, we sought to assess effects healthy subjects by performing radiotracer studies at...
mRNA neoantigen cancer vaccine inducing neoantigen-specific T cell responses holds great promise for immunotherapy; however, its clinical translation remains challenging because of suboptimal prediction accuracy and low delivery efficiency, which compromise the in vivo therapeutic efficacy. We present a lipopolyplex (LPP)–formulated encoding tandem neoantigens as regimen. The LPP-formulated vaccines elicited robust CD8 + three syngeneic murine tumor models (CT26, MC38, B16F10) to suppress...
Summary Background Acute exacerbations in allergic asthmatics may lead to impaired ability clear mucus from the airways, a key factor asthma morbidity. Objective The purpose of this study was determine effect inhaled house dust mite challenge on regional deposition particles and mucociliary clearance (MCC) asthmatics. Methods We used gamma scintigraphy (inhalation 99m Tc ‐sulphur colloid particles) measure particle MCC ( n =12) 4 h following an allergen Dermatophagoides farinae extract; PD...
The bone marrow microenvironment (BMM) can regulate leukemia stem cells (LSCs) via secreted factors. Increasing evidence suggests that dissecting the mechanisms by which BMM maintains LSCs may lead to development of effective therapies for eradication leukemia. Inhibitor DNA binding 1 (ID1), a key transcriptional regulator in LSCs, previously identified us, controls cytokine production BMM, but role ID1 acute myeloid (AML) remains obscure. Here, we report is highly expressed patients with...
The AML1-ETO fusion protein, generated by the t(8;21) chromosomal translocation, is causally involved in nearly 20% of acute myeloid leukemia (AML) cases. In leukemic cells, resides and functions through a stable protein complex, AML1-ETO–containing transcription factor complex (AETFC), that contains multiple (co)factors. Among these AETFC components, HEB E2A, two members ubiquitously expressed E proteins, directly interact with AML1-ETO, confer new DNA-binding capacity to AETFC, are...