A5078993877- Inhalation and Respiratory Drug Delivery
- Asthma and respiratory diseases
- Cystic Fibrosis Research Advances
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Tracheal and airway disorders
- Neonatal Respiratory Health Research
- Respiratory and Cough-Related Research
- Allergic Rhinitis and Sensitization
- Air Quality and Health Impacts
- Dysphagia Assessment and Management
- Respiratory Support and Mechanisms
- Air Quality Monitoring and Forecasting
- Diabetes Management and Research
- Respiratory viral infections research
- Virus-based gene therapy research
- Viral gastroenteritis research and epidemiology
- Transplantation: Methods and Outcomes
- Olfactory and Sensory Function Studies
- Pancreatic function and diabetes
- Stress Responses and Cortisol
- RNA Interference and Gene Delivery
- Aerosol Filtration and Electrostatic Precipitation
- Advanced Chemical Sensor Technologies
- Neuroscience of respiration and sleep
- Injury Epidemiology and Prevention
Johns Hopkins Medicine
2010-2024
Johns Hopkins University
2014-2024
Maryland Department of Natural Resources
2024
University of North Carolina Hospitals
2023
Vrije Universiteit Brussel
2001
Kyoto Prefectural University of Medicine
1999
A collaboration of multidisciplinary experts on the delivery pharmaceutical aerosols was facilitated by European Respiratory Society (ERS) and International for Aerosols in Medicine (ISAM), order to draw up a consensus statement with clear, up-to-date recommendations that enable pulmonary physician choose type aerosol device is most suitable their patient. The focus patient-use aspect devices are currently available. subject divided into different topics, which were turn assigned at least...
This international task force report updates general considerations for bronchial challenge testing and the performance of methacholine test. There are notable changes from prior recommendations in order to accommodate newer delivery devices. Rather than basing test result upon a concentration (provocative (PC20) causing 20% fall forced expiratory volume 1 s (FEV1)), new base delivered dose FEV1 (PD20)). end-point allows comparable results different devices or protocols, thus any suitable...
In the absence of deep inspirations, healthy individuals develop bronchoconstriction with methacholine inhalation. One hypothesis is that inspiration results in bronchodilation. this study, we tested an alternative hypothesis, acts as a bronchoprotector. Single-dose bronchoprovocations were performed after 20 min breath inhibition, nine subjects and eight asthmatics, to establish dose reduces forced expiratory volume 1 s by >15%. The provocation was repeated two five inspirations...
Recently, this international task force reported the general considerations for bronchial challenge testing and performance of methacholine test, a "direct" airway test. Here, provides an updated description pathophysiology methods to conduct indirect tests. Because tests trigger narrowing through activation endogenous pathways that are involved in asthma, tend be specific asthma reveal much about biology but may less sensitive than direct detection hyperresponsiveness. We provide...
Two-dimensional (2D or planar) imaging with (99m)Tc radiolabels enables quantification of whole-lung and regional lung depositions for orally inhaled drug products. This article recommends standardized methodology 2D studies. Simultaneous anterior posterior a dual-headed gamma camera is preferred, but single-headed also acceptable. Correction raw data the effects ray attenuation considered essential accurate quantification, instance, using transmission scanning flood-field source (57)Co....
This March 2009 Workshop Summary Report was sponsored by Product Quality Research Institute (PQRI) based on a proposal the Inhalation and Nasal Technology Focus Group (INTFG) of American Association Pharmaceutical Scientists (AAPS). Participants from pharmaceutical industry, academia regulatory bodies United States, Europe, India, Brazil attended workshop with objective presenting, reviewing, discussing recommendations for demonstrating bioequivalence (BE) that may be considered in...
BACKGROUND. The ability to restore cystic fibrosis transmembrane regulator (CFTR) function with effective small molecule modulators in patients provides an opportunity study relationships between CFTR ion channel function, organ level physiology, and clinical outcomes.
To maximize deposition of an aerosolized dose insulin (mean +/- SD = 0.99 0.06 U/kg body weight) in the lungs subjects with non-insulin-dependent diabetes mellitus (NIDDM), and investigate its efficacy normalizing plasma glucose levels during fasting state.Nonrandomized, placebo-controlled trial.A primary care facility.Six nonobese, nonsmoking volunteers NIDDM. No withdrew from study.Aerosolized was administered by oral inhalation after a 12-hour period fasting. Aerosol generated raindrop...
Objective: To determine the effect of an acute (1 week) and chronic (3 weeks) exposure to E-cigarette (E-cig) emissions on mucociliary clearance (MCC) in murine lungs.Methods: C57BL/6 male mice (age 10.5 ± 2.4 were exposed for 20 min/day aerosol generated by a Joyetech 510-T® E-cig containing either 0% nicotine (N)/propylene glycol (PG) 1 week (n = 6), or 3 weeks 9), 2.4% N/PG one followed measurement MCC. Control 15) not PG alone, N/PG. MCC was assessed gamma camera following aspiration...
The goals of these experiments were to efficiently deliver aerosolized adeno-associated virus (AAV) vector the lungs Rhesus macaques and measure gene transfer expression. To determine optimal lung deposition, we compared four techniques delivering saline admixed with radioisotope 99mtechnetium (99mTc) nebulized through a mouthpiece (Neb Oral), laryngeal airway mask LMA), or an endotracheal tube ETT), bronchoscopically delivered by Microsprayer (PennCentury). Total deposition fraction, as...
We tested the hypothesis that recombinant human deoxyribonuclease 1 (rhDNase) reduces airflow obstruction and improves mucociliary clearance in patients with cystic fibrosis (CF), improvements seen FEV1 FVC after rhDNase treatment are independent of chest physical therapy (CPT). CF inhaled placebo (10 patients) or 2.5 mg rhDNAse aerosol twice a day for six consecutive days. Compared baseline, there were no statistically significant differences between two study groups by Day 6 indices...
We studied the effect of bronchial obstruction on central airway deposition a 0.9% saline aerosol (MMAD = 1.12 micron; sigma g 2.04) labeled with 99mTc sulfur colloid. Radioaerosol was inhaled 2 occasions by 8 patients asthma. The degree at time radioaerosol inhalation measured FEV1. Mucociliary clearance used as an index regional distribution, because from densely ciliated airways occurs more rapidly than peripheral, nonciliated regions lung. Using Weibel lung model and average mucociliary...
A standardized protocol for measuring mucociliary (MCC) and cough clearance (CC) was developed tested at the University of North Carolina Chapel Hill, NC (UNC), Johns Hopkins (JHU), Pittsburgh (Pitt).A total 50 healthy nonsmoking adults with normal lung function were studied three sites: 30 [21 males/9 females (21M/9F)] UNC, 10 (6M/4F) JHU, (4M/6F) Pitt. Subjects inhaled an aerosol (99m)technetium sulfur colloid in 0.9% saline (mass median aerodynamic diameter=5.4 μm) under controlled...
Approximately one third of patients with allergy-induced asthma who are treated aerosolized cromolyn sodium (CS) fail to achieve a full therapeutic effect. This lack effectiveness could involve nonhomogeneous distribution drug in the lung as result high inspiratory flow rates.We sought determine efficacy slow versus faster inhalation CS protecting against allergen challenge asthma.Eight underwent two challenges 30 minutes after pretreatment that was inhaled from large holding chamber at...