A5061306046- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Autophagy in Disease and Therapy
- RNA modifications and cancer
- Plant Gene Expression Analysis
- Antimicrobial Peptides and Activities
- Histone Deacetylase Inhibitors Research
- Protein Degradation and Inhibitors
- Plant Genetic and Mutation Studies
- Genomics and Chromatin Dynamics
- Soybean genetics and cultivation
- Gold and Silver Nanoparticles Synthesis and Applications
- Biosensors and Analytical Detection
- Ubiquitin and proteasome pathways
- Sesame and Sesamin Research
- Protein Hydrolysis and Bioactive Peptides
- Extracellular vesicles in disease
- Enzyme Structure and Function
- Fault Detection and Control Systems
- Multiple Myeloma Research and Treatments
- MicroRNA in disease regulation
- Cancer Mechanisms and Therapy
- Advanced Nanomaterials in Catalysis
- Infrared Target Detection Methodologies
- Polyamine Metabolism and Applications
Nanchang University
2025
Xinjiang University
2025
State Key Laboratory of Food Science and Technology
2025
Henan University of Technology
2021-2024
Kyungpook National University
2016-2019
The decline of endothelial autophagy is closely related to vascular senescence and disease, although the molecular mechanisms connecting these outcomes in cells (VECs) remain unclear. Here, we identify a crucial role for CD44, multifunctional adhesion molecule, controlling ageing VECs. CD44 intercellular domain (CD44ICD) negatively regulates by reducing PIK3R4 PIK3C3 levels disrupting STAT3-dependent PtdIns3K complexes. its homologue clec-31 are increased endothelium Caenorhabditis elegans,...
Geranylgeranyl diphosphate synthase (GGPPS) is the crucial bottleneck in carotenoid biosynthesis. However, low activity limits broad application of GGPPS. In this study, OsGGPPS1 rice was engineered based on ancestral sequence reconstruction (ASR) and semirational design to improve catalytic performances existing The better mutant A22R/A26P with improved enzyme generated ASR. Additionally, mutants as V162A/M218S/F227Y designed using a design. combinatorial assembly d-OsGGPPS1...
Irradiation is extensively utilized in food processing as an effective and convenient method. At present, numerous studies have investigated the potential of irradiation to reduce allergenicity. The objective this study was investigate effects treatment on structure allergenicity liquid solid sesame proteins. Sesame protein extracts lyophilized powders were irradiated at doses 0, 2.5, 5, 7.5, 10 kGy, respectively. proteins by CD spectroscopy, fluorescence indirect competitive ELISA, western...
Surface-modified mesoporous silica nanoparticles (MSNs) have attracted more and attention as promising materials for biomolecule delivery. However, the lack of detailed evaluation relevant to potential cytotoxicity these MSNs is still a major obstacle their applications. Unlike bare amino- or liposome-modified MSNs, we found that polyethylenimine-modified (MSNs-PEI) had no obvious toxicity human umbilical vein endothelial cells (HUVECs) at concentrations up 100 μg/mL. MSNs-PEI induced...
Abstract Autophagy, a highly conserved degradation process of eukaryotic cells, has been proven to be closely related chemoresistance and metastasis non-small-cell lung cancer (NSCLC). Autophagy inhibitors, such as chloroquine (CQ) its derivative hydroxychloroquine (HCQ), shown mediate anticancer effects in preclinical models, especially when combined with chemotherapy. However, the vast majority autophagy including CQ HCQ, actually disrupt lysosomal or/and possibly non-lysosomal processes...
In this paper, we present a light-weight detection transformer, LW-DETR, which outperforms YOLOs for real-time object detection. The architecture is simple stack of ViT encoder, projector, and shallow DETR decoder. Our approach leverages recent advanced techniques, such as training-effective e.g., improved loss pretraining, interleaved window global attentions reducing the encoder complexity. We improve by aggregating multi-level feature maps, intermediate final maps in forming richer...
Dysfunction of histone-modifying enzymes affects chromatin regulation and is involved in carcinogenesis, tumour progression other diseases. Histone methyltransferases are a family key enzymes, but their structures, functions mechanisms incompletely understood, thus constraining drug-design efforts. Here, preliminary steps towards structure–function studies Schizosaccharomyces pombe Set7, putative histone methyltransferase the first yeast full-length SET-domain-containing protein to be...
NSD3 is a member of six H3K36-specific histone lysine methyltransferases in metazoans. Its overexpression or mutation implicated developmental defects and oncogenesis. Aside from the well-characterized catalytic SET domain, has multiple clinically relevant potential chromatin-binding motifs, such as proline–tryptophan–tryptophan–proline (PWWP), plant homeodomain (PHD), adjacent Cys-His-rich domain located at C-terminus. The crystal structure individual domains available, this structural...
Abstract Chromatin dynamics are plastic processes controlled by epigenetic modifications on the DNA and histone tails that play a critical role in gene expression. Interestingly, histones also under influence of exogenous factors such as pollutants, smoking, sun exposure, daily diet, alcohol consumption environmental stress. Departure from “normal” cellular homeostatic conditions is influenced aberrant accumulation specific patterns, which may contribute to onset diseases ranging diabetes...
Abstract Dynamics and plasticity of chromatin regulation is mediated by a molecular ballet writers, readers erasers epigenetic marks on both DNA histones. The pattern histone modifications may define code, which part intricate networks that ultimately regulate transcriptional events. Dysfunction methylation affects involved in an increasing number pathologies from cellular transformation to tumor progression other diseases. However, methyltransferase (HMTase) pathways remain be further...
Histone methylation by histone methyltransferases (HMTases) has a key role in transcriptional regulation. Discrepancies between the known HMTases and lysine methylome suggest that novel remain to be identified. Characterization of new may clarify regulation mechanisms modification. Here we report discovery, characterization, crystal structure Schizosaccharomyces pombe Set7 (SPCC297.04c), first identified HMTase methylating uncharted H3 37 (H3K37) mark. forms dimer with its substrate-binding...
<title>Abstract</title> Autophagy, a highly conserved degradation process of eukaryotic cells, has been proved to be closely related chemoresistance and metastasis non-small-cell lung cancer (NSCLC). Autophagy inhibitors, such as chloroquine (CQ) its derivative hydroxychloroquine (HCQ), shown mediate anti-cancer effects in preclinical models, especially when combined with chemotherapy. However, the vast majority autophagy including CQ HCQ, actually disrupt lysosomal or/and possibly...