A5100322287- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Antimicrobial Peptides and Activities
- RNA Interference and Gene Delivery
- Dendrimers and Hyperbranched Polymers
- Graphene and Nanomaterials Applications
- Glycosylation and Glycoproteins Research
- Lipid Membrane Structure and Behavior
- Advanced Drug Delivery Systems
- Cancer, Hypoxia, and Metabolism
- Protein Hydrolysis and Bioactive Peptides
- Copper-based nanomaterials and applications
- Chemical Thermodynamics and Molecular Structure
- Inhalation and Respiratory Drug Delivery
- Peptidase Inhibition and Analysis
- Meat and Animal Product Quality
- Protein Interaction Studies and Fluorescence Analysis
- Advanced Polymer Synthesis and Characterization
- Analytical Chemistry and Chromatography
- Biochemical and Structural Characterization
- Bee Products Chemical Analysis
- Healthcare and Venom Research
- Crystallization and Solubility Studies
- Probiotics and Fermented Foods
- Supramolecular Self-Assembly in Materials
Capital Medical University
2024-2025
Henan University of Technology
2013-2024
Xi'an Jiaotong University
2016-2023
Zhengzhou University
2023
Kunming University of Science and Technology
2023
Northwest Normal University
2023
Jilin University
2020
Xiangtan University
2019
Sichuan University
2016-2017
State Key Laboratory of Biotherapy
2016
Honeybee venom is a complicated defensive toxin that has wide range of pharmacologically active compounds. Some these compounds are useful for human therapeutics. There two major forms honeybee used in pharmacological applications: manually (or reservoir disrupting) extracted glandular (GV), and through the use electrical stimulation (ESV). A proteome comparison an understanding phosphorylation status ESV, still very limited. Here, proteomes GV ESV were compared using both gel-based gel-free...
Satisfactory drug loading capacity and stability are the two main factors that determine anti-cancer performance. In general, of micelles is reduced when (DL) increased. Therefore, it was a challenge to have high good stability. this study, we introduced hydrophilic poly (L-Lysine) (PLL) segment with different molecular-weights into monomethoxy (ethylene glycol)-poly (D, L-lactide) (MPEG-PDLLA) block copolymer obtain series novel triblock MPEG-PDLLA-PLL copolymers. We found formed by specific MPEG
This work reports a facile ligand-free method for the rapid and highly specific separation of histidine (His)-rich proteins using CuFe2O4 magnetic nanocrystal clusters (MNCs). Monodispersed MNCs were synthesized via simple economical one-pot hydrothermal process. The resulting characterized in detail. measurements indicated that exhibited good dispersion, high crystallinity, superparamagnetic properties. Moreover, obtained had saturation magnetization (45.1 emu g-1), which was sufficient to...
Competitive consumption of nutrients between rapidly proliferating cancer cells and T results in an immunosuppressive tumor microenvironment (TME) nutrient deprivation cells, which can cause low response rate resistance to immunotherapies. In this study, we proposed a dual-mechanism based partitioning nanoregulator (designated as DMNPN), simultaneously regulate the TME enhance cell availability. DMNPN consists charge-reversal biodegradable mesoporous silica, encapsulating glycolysis...
Given the growing incidence of dementia-related disorders in aging population, identifying effective treatments for age-related cognitive decline (ARCD) is crucial. Shenwu Capsule (SWC), shown to have therapeutic efficacy phase III clinical trials senile dementia, has unclear mechanisms and active ingredients. Aged mice were administered SWC orally three months, behavioral tests, including Morris water maze, Y novel object recognition, assessed learning memory. Neuronal damage was evaluated...
Royal jelly (RJ) is a proteinaceous secretion produced from the hypopharyngeal and mandibular glands of nurse bees. It plays vital roles in honeybee biology improvement human health. However, some proteins remain unknown RJ, mapping N-glycosylation modification sites on RJ demands further investigation. We used two different liquid chromatography-tandem mass spectrometry techniques, complementary N-glycopeptide enrichment strategies, bioinformatic approaches to gain better understanding...
Amphiphilic block copolymers have attracted a great deal of attention in drug delivery systems. In this work, series monomethoxy-poly (ethylene glycol)-poly (ε-caprolactone-co-D,L-lactide) (MPEG-PCLA) with variable composition poly (ε-caprolactone) (PCL) and (D,L-lactide) (PDLLA) were prepared via ring-opening copolymerization ε-CL D,L-LA the presence MPEG stannous octoate. The structure molecular weight characterized by nuclear magnetic resonance (NMR) gel permeation chromatography (GPC)....
Abstract Vascular smooth muscle cells (VSMCs) are a major cell type of the arterial wall and their functionality is associated with blood pressure regulation. Although royal jelly (RJ) has reported effects on anti-hypertension, mechanism regulation by protein 1 (MRJP1), most abundant RJ protein, still unknown. The mrjp1 gene was inserted into mouse VSMCs to investigate how MRJP1 influences VSMC functional proteomic analysis. expression in significantly reduced contraction, migration...
Abstract Self-assembled polymeric micelles have been widely applied in drug delivery systems. In this study, we found that pH value of micellar system solution was the decisive factor physical stability. Furthermore, weak basic could maintain clarification for a relative long time. To investigate stability different solutions, particle size and docetaxel content remaining were detected at predetermined time points. The crystallographic assay freeze-drying powder characterized by an X-ray...
Peptide self-assembly on substrates is currently an intensively studied topic that provides a promising strategy for fabrication of soft materials and also important revealing the surface chemistry amyloidogenic proteins aggregate cell membranes. We investigated fibrogenesis β-sheet forming peptide Aβ26−35 supported lipid bilayers (SLBs) by in situ atomic force microscopy (AFM), circular dichroism (CD), attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy. The...
Abstract Upon repeated administration, empty pegylated liposomes lose their long-circulating characteristics, referred to as the accelerated blood clearance (ABC) phenomenon. To investigate whether cytotoxic drug-containing could also elicit a similar phenomenon, two liposomal antitumour drugs (doxorubicin and mitoxantrone) were prepared, they administrated twice in same animals with 10-day interval at dose level of 8 mg kg−1 (pegylated doxorubicin) 4 mitoxantrone). By comparing overall...
Upon repeated administration, empty pegylated liposomes lose their long-circulating characteristics, referred to as the accelerated blood clearance (ABC) phenomenon. To investigate whether cytotoxic drug-containing could also elicit a similar phenomenon, two liposomal antitumour drugs (doxorubicin and mitoxantrone) were prepared, they administrated twice in same animals with 10-day interval at dose level of 8 mg kg(-1) (pegylated doxorubicin) 4 mitoxantrone). By comparing overall...
In this paper, two nanoscale preparations were described for docetaxel encapsulation using poly(epsilon-caprolactone)poly(ethylene glycol)-poly(epsilon-caprolactone) (PCEC) copolymer as carrier treating malignant tumor. The first formulation was docetaxel-loaded PCEC micelle (D-M), which characterized by XRD, TEM and Malvern laser particle size drug release studies. highest drug-loading of in about 22.1 +/- 1.9%, optimized average diameter polydispersity index 25.2 1.1 nm, 0.13 0.12,...
Abstract Objectives Pegylated liposome formulations of vinorelbine with prolonged circulation half-life (t½) are desirable. However, DSPE-PEG could affect loading into vesicles due to electrostatic interactions. To resolve this problem, chol-PEG was used prepare pegylated liposomal and the factors affecting drug plasma pharmacokinetics were investigated. Methods Vinorelbine loaded liposomes using a novel triethylamine 5-sulfosalicylate gradient. The effects cholesterol on Pharmacokinetic...
Antimicrobial peptides and their analogues have become substitutes for antibiotics in recent years. The antimicrobial peptide analogue SAMP‐A4‐C8 ( n ‐octanoic‐VRLLRRRI) with high activity was found our lab. We speculate that it may kill pathogens by some lethal mechanism of action. In the present investigation, microbicidal activities its action were investigated. results demonstrated had against Staphylococcus aureus Candida albicans cell disruption. Based on activities, we believe is...