A5101800032- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA modifications and cancer
- Medical Research and Treatments
- Ferroptosis and cancer prognosis
- Research in Cotton Cultivation
- Traditional Chinese Medicine Analysis
- Cancer Immunotherapy and Biomarkers
- Metabolomics and Mass Spectrometry Studies
- Echinoderm biology and ecology
- Berberine and alkaloids research
- Protease and Inhibitor Mechanisms
- Immune Cell Function and Interaction
- Bone Metabolism and Diseases
- Osteoarthritis Treatment and Mechanisms
- HVDC Systems and Fault Protection
- Rheumatoid Arthritis Research and Therapies
- Cancer Mechanisms and Therapy
- Biological Activity of Diterpenoids and Biflavonoids
- Bamboo properties and applications
- Natural Fiber Reinforced Composites
- Innovative concrete reinforcement materials
- Gut microbiota and health
- Seaweed-derived Bioactive Compounds
- Cancer, Lipids, and Metabolism
First Affiliated Hospital of Heilongjiang University of Chinese Medicine
2020-2024
Xi'an University of Science and Technology
2024
Heilongjiang University of Chinese Medicine
2021
Abstract Cisplatin (DDP) based chemotherapy occurs a reduced therapeutic effect on the later treatment of ovarian cancer (OC) due to DDP resistance. Astragaloside II (ASII), natural product extracted from Radix Astragali , has shown promising anticancer effects. However, effects ASII OC have not been clarified. In this study, we found that inhibited cell growth and promoted apoptosis DDP‐resistant cells in vitro vivo. Further study showed downregulated multidrug resistance‐related protein...
Gastric cancer (GC) is a malignant disease of digestive tract. Clinically, radiation therapy widely applied in treating GC, while with undesirable outcome due to tumor re-proliferation and recurrence metastasis after radiation. Therefore, it crucial explore potential molecular mechanisms develop therapeutic strategies. The present study found that miR-26a-5p has low expression GC patients could regulate Wnt5a inhibit growth, which was target for GC. To the related mechanism GC.MiR-26a-5p...
Exosomes are emerging tools for transporting lipids, proteins, microRNAs (miRNAs), or other biomarkers clinical purposes. They have produced widespread concern in managing human diseases, including osteosarcoma (OS). This study focuses on the function of serum-derived exosomal miR-15a growth OS cells and mechanism action. Differentially expressed genes between normal samples were screened using two datasets GSE70367 GSE65071. was poorly expressed, whereas GATA-binding protein 2 (GATA2)...
Purpose: To investigate the effect and regulatory mechanism of fucoxanthin (FX) on oral squamous cell carcinoma (OSCC).
 Methods: Human OSCC SCC9 Cal27 cells were treated with different concentrations FX (7.5, 15, 30 μM) to determine viability, number colonies, apoptosis rate using methyl thiazolyl diphenyl-tetrazolium bromide (MTT) assay, crystal violet staining, flow cytometry, respectively. In addition, spheres was determined by a sphere-forming assay. The stem levels pathway-related...
Colorectal cancer is a common clinical malignant tumor of the digestive tract, and intestinal flora has played an important role in development colorectal cancer. Bifidobacteria, as one main dominant florae can inhibit occurrence through various mechanisms. Recent studies have shown that traditional Chinese medicine regulate abundance bifidobacteria tract exhibit anti-tumor effects on Detailed investigations revealed mechanisms treatment involve three aspects: production short-chain fatty...
Objective. To perform gene set enrichment analysis (GSEA) and of immune cell infiltration on non-small-cell lung cancer (NSCLC) expression profiling microarray data based bioinformatics, construct TICS scoring model to distinguish prognosis time, screen key genes cancer-related pathways for NSCLC treatment, explore differential in patients, predict potential therapeutic targets NSCLC, provide new directions the treatment NSCLC. Methods. Transcriptome 81 patients GEO database were used...
This study aims to investigate centrosomal protein 70 (CEP70) in prostate cancer and its effects on angiogenesis tumour metastasis elucidate molecular mechanisms.