A5050611908- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA modifications and cancer
- Hepatocellular Carcinoma Treatment and Prognosis
- MicroRNA in disease regulation
- Liver physiology and pathology
- Cancer Genomics and Diagnostics
- Pancreatic and Hepatic Oncology Research
- Lipid metabolism and disorders
- Ginseng Biological Effects and Applications
- Ferroptosis and cancer prognosis
- Epigenetics and DNA Methylation
- Nutritional Studies and Diet
- Cancer Research and Treatments
- Genetics and Neurodevelopmental Disorders
- Cancer Mechanisms and Therapy
- PI3K/AKT/mTOR signaling in cancer
- Liver Disease Diagnosis and Treatment
- Gene Regulatory Network Analysis
- Urinary and Genital Oncology Studies
- Microtubule and mitosis dynamics
- Antioxidant Activity and Oxidative Stress
- Nuclear Receptors and Signaling
- Nutrition and Health in Aging
- Vitamin C and Antioxidants Research
Fudan University
1993-2025
Minhang District Central Hospital
2017-2025
Chengdu University of Traditional Chinese Medicine
2024
China Metallurgical Geology Bureau
2023
Zhongshan Hospital
2017-2023
Tianjin University
2022
Shanghai Jiao Tong University
2020
Ministry of Education of the People's Republic of China
2018-2019
Sun Yat-sen University
2017-2018
The First Affiliated Hospital, Sun Yat-sen University
2017-2018
Long non-coding RNAs (lncRNAs) are crucial in the invasion, angiogenesis, progression, and metastasis of hepatocellular carcinoma (HCC). The lncRNA MYLK-AS1 promotes growth invasion HCC through EGFR/HER2-ERK1/2 signaling pathway. However, clinical significance still needs to be further determined.Bioinformatic analysis was performed determine potential relationship among MYLK-AS1, miRNAs mRNAs. A total 156 samples normal liver paired tissues from patients were used evaluate expression by...
Global metabolite identification of complex compound mixtures in biological systems is a very challenging task. Herein, we developed and validated chemicalome to metabolome matching approach by taking herbal medicine as an example delineate the metabolic networks systems. This consists five steps data processing including raw output, endogenous background subtraction, parent differentiation, correlation, final validation via manual fragment comparison. Chemicalome core step this approach,...
Using a method optimized in hepatocellular carcinoma (HCC), we established patient-derived xenograft (PDX) models with an increased take rate (42.2%) and demonstrated that FBS +10% dimethyl sulfoxide exhibited the highest tumor efficacy. Among 254 HCC patients, 103 stably transplantable lines could be serially passaged, cryopreserved revived were established. These maintained diversity of essential features original specimens at histological, transcriptome, proteomic genomic levels. Tumor...
Abstract The aim of this study was to identify novel prognostic mRNA and microRNA (miRNA) biomarkers for hepatocellular carcinoma (HCC) using methods in systems biology. Differentially expressed mRNAs, miRNAs, long non-coding RNAs (lncRNAs) were compared between HCC tumor tissues normal liver Cancer Genome Atlas (TCGA) database. Subsequently, a prognosis-associated co-expression network, an mRNA–miRNA regulatory mRNA–miRNA–lncRNA network constructed through Cox survival analysis. Seven...
Prognosis of hepatocellular carcinoma (HCC) remains poor due to high recurrence rate and ineffective treatment options, highlighting the need better understand mechanism metastasis in HCC.We first collected messenger RNA (mRNA) expression data from 442 cases HCC patients The Cancer Genome Atlas (TCGA) database as well 251 Zhongshan Hospital during 2009 2010 analyze pattern tissue microarray (TMA) baculoviral IAP repeat containing 3 (BIRC3). Then, we used BIRC3 gain-of-function...
The effects of long non-coding RNAs (lncRNAs) on hepatocellular carcinoma (HCC) remain largely unclear. In this study, we identified an interferon (IFN)-γ-induced LncRNA, LncRNA00364, in HCC by microarray. LncRNA00364 displays lower expression tumor samples compared to paired normal controls. Overexpression inhibits cell proliferation, G1/S cycle progression and promotes apoptosis lines. Consistently, overexpression leads decreased formation vivo. Mechanistically, specifically binds with...
Liver cancer is the second leading cause of cancer-related deaths and characterized by heterogeneity drug resistance. Patient-derived xenograft (PDX) models have been widely used in research because they reproduce characteristics original tumors. However, current studies liver PDX mice are scattered number available too small to represent patients. To improve this situation complement related resources, here we constructed a comprehensive database, PDXliver, integrate analyze...
Accumulating evidence suggests that long non-coding RNA (lncRNA) plays important roles in some malignant tumors. However, the mechanism underlying how lncRNA regulates hepatocellular carcinoma (HCC) process remains largely unknown. In this study, we explored potential role of 00607 as a novel tumor suppressor HCC. examined regulation by inflammatory cytokine necrosis factor-α (TNF-α) and interleukin-6 (IL-6). We also determined expression LINC000607 159 HCC tumors paired adjacent tissues....
Abstract Background Sustained activation of hepatocyte growth factor (HGF)/c-MET signaling is a major driver hepatocellular carcinoma (HCC) progression, but underlying mechanism unclear. ArfGAP With SH3 Domain, Ankyrin Repeat And PH Domain 2 (ASAP2) can reportedly activate GTPases and promote receptor tyrosine kinase signaling. However, the exact role ASAP2 in HCC, especially for c-MET activation, also remains elusive. Methods expression levels HCC tissues cells were quantified using...
Background: Previous studies reported that stress-induced phosphoprotein 1 (STIP1) can be secreted by hepatocellular carcinoma (HCC) cells and is increased in the serum of HCC patients. However, therapy-monitoring prognostic value STIP1 remains unclear. Here, we aimed to systemically explore significance HCC. Methods: A total 340 patients were recruited this study; 161 underwent curative resection 179 transcatheter arterial chemoembolization (TACE). Serum was detected enzyme-linked...
Pancreatic ductal adenocarcinoma (PDAC) is one of the most fatal malignancies worldwide.PDAC prognostic and diagnostic biomarkers are still being explored.The aim this study to establish a robust molecular signature that can improve ability predict PDAC prognosis.155 overlapping differentially expressed genes between tumor non-tumor tissues from three Gene Expression Omnibus (GEO) datasets were explored.A least absolute shrinkage selection operator method (LASSO) Cox regression model was...
Liver cancer is a lethal disease that associated with poor prognosis. In order to identify the functionally important genes liver may reveal novel therapeutic avenues, we performed integrated analysis profile miRNA and mRNA expression levels for tumors compared normal samples in The Cancer Genome Atlas (TCGA) database. We identified 405 differentially expressed 233 miRNAs tumor controls. addition, also pathway found mitogen-activated protein kinases (MAPKs) G-protein coupled receptor (GPCR)...
Hypoxia is a critical aspect of tumor biology and has been associated with poor prognosis resistance to traditional therapy. In the present study, differentially expressed genes microRNAs (miRNAs/miRs) were screened for in hepatocellular carcinoma (HCC) cell line Huh7 under hypoxic conditions. On basis microarray data, 11,508 mRNAs 58 miRNAs exhibiting ≥1.5-fold change expression conditions identified. Gene Ontology (GO) Kyoto Encyclopedia or Genes Genomes pathway analysis revealed that...
Abstract Previous research suggests that far upstream element-binding protein 1 (FUBP1) plays an important role in various tumors including epatocellular carcinoma (HCC). However, the of FUBP1 liver cancer remains controversial, and regulatory pathway by awaits to be determined. This study aims identify HCC progression. Our result shows high level expression predicts poor prognosis after surgery. Overexpression promotes proliferation, invasion, metastasis activating transforming growth...
An amendment to this paper has been published and can be accessed via the original article.
Introduction: The WW domain-containing oxidoreductase (WWOX), widely expressed in human tissues, is considered as a tumor suppressor gene and plays an important role the incidence progression of cancer, HCC included. This study was to investigate correlation between single nucleotide polymorphisms (SNPs) WWOX prognosis hepatocellular carcinoma (HCC) patients. Materials Methods: After total 152 patients were recruited, 8 cases with recurrence within 2-years after operation without selected...
Abstract Background : Long non-coding RNAs (lncRNAs) are crucial in the invasion, angiogenesis, progression, and metastasis of hepatocellular carcinoma (HCC). The lncRNA MYLK-AS1 promotes growth invasion HCC through EGFR/HER2-ERK1/2 signaling pathway. However, clinical significance still needs to be further determined. Methods Bioinformatic analysis was performed determine potential relationship among MYLK-AS1, miRNAs mRNAs. A total 156 samples normal liver paired tissues from patients were...
Abstract BackgroundLong non-coding RNA is essential for the metastasis, invasion, angiogenesis and progression of hepatocellular carcinoma (HCC). However, their specific mechanisms are still controversial. Here, we found that Lnc-MYLK-AS1 a potential oncogene. We systematically analyzed clinical significance mechanism in HCC invasion angiogenesis.MethodsDetermine research goals through bioinformatics analysis. The expression MYLK-AS1 matched tumor non-tumor tissues 156 patients was detected...
Thermal ablation for renal cell carcinoma in nephron-sparing surgery has been extensively investigated. However, data regarding pelvic tumors with refractory hematuria are scarce. Herein, we report a case of recurrent an 87-year-old woman with. 3.5 × 4.1 cm mass the right pelvis on imaging examinations, which was clinically diagnosed as carcinoma. After ineffective artery embolization, minimally invasive percutaneous thermal recommended after multidisciplinary consultation. Although...