A5072511605- Memory and Neural Mechanisms
- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Memory Processes and Influences
- Visual perception and processing mechanisms
- Functional Brain Connectivity Studies
- Cognitive Science and Mapping
- Spatial Cognition and Navigation
- Cognitive Functions and Memory
- Action Observation and Synchronization
- Gaze Tracking and Assistive Technology
- Neuroscience and Neural Engineering
- Retinal Development and Disorders
- EEG and Brain-Computer Interfaces
- Olfactory and Sensory Function Studies
- Linguistic Education and Pedagogy
- Radiation Effects and Dosimetry
- Visual Attention and Saliency Detection
- Sleep and Wakefulness Research
- Photoreceptor and optogenetics research
- Neurobiology of Language and Bilingualism
- Advanced MRI Techniques and Applications
- Neural Networks and Applications
- Motor Control and Adaptation
- Nicotinic Acetylcholine Receptors Study
Peking University
2014-2025
Chinese Institute for Brain Research
2014-2025
McGovern Institute for Brain Research
2023
Center for Life Sciences
2014-2022
King University
2019-2022
Peking University Sixth Hospital
2021
Zhejiang University
2017-2019
Newcastle University
2015
Copenhagen University Hospital
2015
Bispebjerg Hospital
2015
Episodic memory or for the detailed events in our lives is critically dependent on structures of medial temporal lobe (MTL). A fundamental component episodic order items within an episode. To understand contribution individual MTL to temporal-order memory, we recorded single-unit activity and local field potential from three areas (hippocampus entorhinal perirhinal cortex) visual area TE as monkeys performed a task. Hippocampus provided incremental timing signals one item presentation next,...
Bidirectional signaling between neocortex and limbic cortex has been hypothesized to contribute the retrieval of long-term memory. We tested this hypothesis by comparing time courses perceptual memory-retrieval signals in two neighboring areas temporal cortex, area TE (TE) perirhinal (PRh), while monkeys were performing a visual pair-association task. Perceptual signal reached before PRh, confirming its forward propagation. In contrast, appeared earlier neurons then gradually recruited...
The macaque inferotemporal (IT) cortex, which serves as the storehouse of visual long-term memory, consists two distinct but mutually interconnected areas: area TE (TE) and 36 (A36). In present study, we tested whether memory encoding is put forward at this stage, i.e., association between representations different semantically linked objects proceeds from to A36. To address question, trained monkeys in a pair-association (PA) task, after single-unit activities were recorded A36 during PA...
Significance We compared the patterns of neural activity in cells lateral prefrontal cortex (PFC) with three areas within medial temporal lobes (MTL) and visual area TE nonhuman primates during encoding phase a temporal-order memory task. While many both regions signaled information about item identity, order, combination two, these used largely distinct strategies. PFC specific conjunction order prominent stimulus-selective delay that is well suited for planning actions. By contrast, MTL...
Visual long-term memory in primates has been assessed by using the pair-association (PA) task, which a subject retrieves and chooses paired associate of cue picture. Our previous studies on single neurons anterior inferotemporal (AIT) cortex suggested their roles representing associates mind. To test possibility that delay activity AIT is related to particular picture as sought target, we devised PA with color switch (PACS) task. In PACS necessity for retrieval its initiation time were...
Neural dynamics are thought to reflect computations that relay and transform information in the brain. Previous studies have identified neural population many individual brain regions as a trajectory geometry, preserving common computational motif. However, whether these populations share particular geometric patterns across brain-wide remains unclear. Here, by mapping widely temporal/frontal/limbic cortical subcortical structures of monkeys, we show 10 populations, including 2,500 neurons,...
We examine the hypothesis that form representation in anterior inferotemporal (AIT) cortex is acquired through learning. According to this hypothesis, perceptual aspects of temporal association area are closely related its visual representation, response selectivity AIT neurons can be influenced by experience. On basis neurophysiological evidence, we summarize two neuronal mechanisms subserve acquisition neurons. The first mechanism tuning particular stimuli were learned a cognitive task....
We examined timing-related signals in primate hippocampal cells as animals performed an object-place (OP) associative learning task. found with firing rates that incrementally increased or decreased across the memory delay interval of task, which we refer to incremental timing (ITCs). Three distinct categories ITCs were identified. Agnostic did not distinguish between different trial types. The remaining two signaled time and context together: One category tracked depending on behavioral...
The perirhinal cortex, which is critical for long-term stimulus-stimulus associative memory, consists of two cytoarchitectonically distinct subdivisions: area 35 (A35) and 36 (A36). Previous electrophysiological studies suggested that macaque A36 involved in both association retrieval processes during a visual pair-association task. However, the neuronal properties A35 have never been examined because located very narrow region, makes it difficult to systematically record single-unit...
A number of studies have shown that the perirhinal (PRh) cortex, which is part medial temporal lobe memory system, plays an important role in declarative long-term memory. The PRh cortex contains neurons represent visual aim present study to characterize anatomical organization forward projections mediate information flow from area TE cortex. In monkeys performing a pair-association task, we conducted extensive mapping neuronal responses anteroventral (TEav) and 36 (A36) Then, three...
The macaque inferotemporal cortex, which is involved in encoding and retrieval of visual long-term memory, consists two distinct but mutually interconnected areas: area TE (TE) 36 (A36). In the present study, we compared delay-period activities subdivisions terms their signal contents. We recorded single-unit from A36 during a delayed pair association task, monkeys were required to choose paired associate cue stimulus after delay period. stimulus-selective single neurons characterized by...
Abstract While the hippocampus (HPC) is a prime candidate combining object identity and location due to its strong connections ventral dorsal pathways via surrounding medial temporal lobe (MTL) areas, recent physiological studies have reported spatial information in pathway downstream target MTL. However, it remains unknown whether object–location association proceeds along MTL before HPC. To address this question, we recorded neuronal activity from area anterior inferotemporal cortex (TE)...
The standard consolidation theory suggests that the hippocampus (HPC) is critically involved in acquiring new memory, while storage and recall gradually become independent of it. Converging studies have shown separate involvements perirhinal cortex (PRC) parahippocampal (PHC) item spatial processes, whereas HPC relates to a context. These 2 strands literature raise following question; which brain region process item-location associative memory? To solve this question, study applied an (ILA)...
Abstract Perceptual processing along the ventral visual pathway to hippocampus (HPC) is hypothesized be substantiated by signal transformation from retinotopic space relational space, which represents interrelations among constituent elements. However, our perception necessarily reflects first person’s perspective based on space. To investigate this two-facedness of perception, we compared neural activities in temporal lobe (anterior inferotemporal cortex, perirhinal and parahippocampal...
Abstract A cognitive map, representing an environment around oneself, is necessary for spatial navigation. However, compared with its constituent elements such as individual landmarks, neural substrates of coherent information, which consists in a relationship among the elements, remain largely unknown. The present study investigated how brain codes map-like representations virtual specified by relative positions three objects. Representational similarity analysis revealed object-based...
The ability to use stored information in a highly flexible manner is defining feature of the declarative memory system. However, neuronal mechanisms underlying this flexibility are poorly understood. To address question, we recorded single-unit activity from hippocampus 2 nonhuman primates performing newly devised task requiring monkeys retrieve long-term item-location association and then it flexibly different circumstances. We found that hippocampal neurons signaled both mnemonic...
Naming individual objects is accompanied with semantic recognition. Previous studies examined brain-networks responsible for these operations individually. However, it remains unclear how are related. To address this problem, we the during a novel object-naming task, requiring participants to name animals in photographs at specific-level (e.g., "pigeon"). When could not remember specific names, they answered basic names "bird"). After fMRI scanning rated familiarity of based on their sense...
Our mental representation of egocentric space is influenced by the disproportionate sensory perception body. Previous studies have focused on neural architecture for representations within visual field. However, underlying body still unclear. To address this problem, we applied both functional Magnitude Resonance Imaging (fMRI) and Magnetoencephalography (MEG) to a spatial-memory paradigm using virtual environment in which human participants remembered target location left, right, or back...