A5046492476- Memory and Neural Mechanisms
- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Memory Processes and Influences
- Lipid Membrane Structure and Behavior
- Advanced Fluorescence Microscopy Techniques
- Cellular transport and secretion
- Forecasting Techniques and Applications
- Functional Brain Connectivity Studies
- Child and Animal Learning Development
- Retinal Development and Disorders
- Sleep and Wakefulness Research
- Bacterial Genetics and Biotechnology
- Protein Structure and Dynamics
- Diamond and Carbon-based Materials Research
- Glycosylation and Glycoproteins Research
- Ion-surface interactions and analysis
- Advanced biosensing and bioanalysis techniques
- Bacteriophages and microbial interactions
- Epigenetics and DNA Methylation
- Advanced Biosensing Techniques and Applications
- Nanopore and Nanochannel Transport Studies
- Opportunistic and Delay-Tolerant Networks
- Force Microscopy Techniques and Applications
University of Pennsylvania
2021-2024
New York University
2014-2022
North Carolina State University
2008-2020
Direct human brain recordings have confirmed the presence of high-frequency oscillatory events, termed ripples, during awake behavior. While many prior studies focused on medial temporal lobe (MTL) ripples memory retrieval, here we investigate encoding. Specifically, ask whether encoding predict and how memories are subsequently recalled. Detecting from MTL electrodes implanted in 116 neurosurgical participants (
High-frequency oscillatory events, termed ripples, represent synchrony of neural activity in the brain. Recent evidence suggests that medial temporal lobe (MTL) ripples support memory retrieval. However, it is unclear if signal reinstatement episodic memories. Analyzing electrophysiological MTL recordings from 245 neurosurgical participants performing recall tasks, we find rate hippocampal rises just prior to free recently formed This prerecall ripple effect (PRE) stronger CA1 and...
We report the profiling of 5-methyl cytosine distribution within single genomic-sized DNA molecules at a gene-relevant resolution. This method linearizes and stretches by confinement to channels with dimension about 250×200nm2. The methylation state is detected using fluorescently labeled methyl-CpG binding domain proteins (MBD), high signal contrast low background. barcodes consisting methylated non-methylated segments are generated, both short long concatemers demonstrating spatially...
We examined timing-related signals in primate hippocampal cells as animals performed an object-place (OP) associative learning task. found with firing rates that incrementally increased or decreased across the memory delay interval of task, which we refer to incremental timing (ITCs). Three distinct categories ITCs were identified. Agnostic did not distinguish between different trial types. The remaining two signaled time and context together: One category tracked depending on behavioral...
The CA3 and dentate gyrus (DG) regions of the hippocampus are considered key for disambiguating sensory inputs from similar experiences in memory, a process termed pattern separation. neural mechanisms underlying separation, however, have been difficult to compare across species: rodents offer robust recording methods with less human-centric tasks, while humans provide complex behavior potential. To overcome these limitations, we trained monkeys perform visual separation task those used...
Biological membranes have distinct geometries that confer specific functions. However, the molecular mechanisms underlying phenomenological geometry/function correlations remain elusive. We studied effect of membrane geometry on localization membrane-bound proteins. Quantitative comparative experiments between two most abundant cellular geometries, spherical and cylindrical, revealed regulates spatial segregation The measured geometry-driven reached 50-fold for same mean curvature,...
In response to recommendations redefine statistical significance p ≤ .005, we propose that researchers should transparently report and justify all choices they make when designing a study, including the alpha level.
High-frequency oscillatory events, termed ripples, represent synchrony of neural activity in the brain. Recent evidence suggests medial temporal lobe (MTL) ripples support memory retrieval. However, it is unclear if signal reinstatement episodic memories. Analyzing electrophysiological MTL recordings from 219 neurosurgical participants performing recall tasks, we find that rate hippocampal rises just prior to free recently-formed This pre-recall ripple effect (PRE) stronger CA1 and dentate...
Abstract The role of the hippocampus in recognition memory has long been a source debate. Tasks used to study that typically require an explicit probe, where participant must make response prove they remember, yield mixed results on hippocampal involvement. Here, we tasked monkeys freely view naturalistic videos, and only tested their via looking times for two separate novel versus repeat video conditions each trial. Notably, large proportion (>30%) neurons differentiated these videos...
Abstract The CA3 and dentate gyrus (DG) regions of the hippocampus are considered key for disambiguating sensory inputs from similar experiences in memory, a process termed pattern separation. neural mechanisms underlying separation, however, have been difficult to compare across species: rodents offer robust recording methods with less human-centric tasks while humans provide complex behavior potential. To overcome these limitations, we trained monkeys perform visual separation task those...
Abstract The role of the hippocampus in recognition memory has long been a source debate. Tasks used to study that typically require an explicit probe, where participant must make response prove they remember, yield mixed results on hippocampal involvement. Here, we tasked monkeys freely view naturalistic videos, and only tested their via looking times for two separate novel v. repeat video conditions each trial. Notably, large proportion neurons differentiated these videos changes firing...
An integral feature of human memory is the ability to recall past events. What distinguishes such episodic from semantic or associative joint encoding and retrieval "what," "where," "when" (WWW) for Surprisingly, little work has addressed whether all three components WWW are retrieved with equal fidelity when remembering episodes. To study this question, we created a novel task where participants identified matched mismatched still images sampled recently viewed synthetic movies. The...
Abstract Recent human electrophysiology work has uncovered the presence of high frequency oscillatory events, termed ripples, during awake behavior. This prior focuses on ripples in medial temporal lobe (MTL) memory retrieval. Few studies, however, investigate item encoding. Many studies have found neural activity encoding that predicts later recall, subsequent effects (SMEs), but it is unclear if also predict recall. Detecting 116 neurosurgical participants (n = 61 male) performing an...
In response to recommendations redefine statistical significance p ≤ .005, we propose that researchers should transparently report and justify all choices they make when designing a study, including the alpha level.
An integral feature of human memory is the ability to recall past events. What distinguishes such episodic from associative and semantic memories joint encoding retrieval “what,” “where,” “when” (WWW) Here, we investigated whether WWW components episodes are retrieved with equal fidelity. Using a novel task where participants were probed on recently-viewed synthetic movie, found fundamental differences in mnemonic accuracy between these components. The had lowest was most severely influenced...