A5022403100- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Ultrasound and Hyperthermia Applications
- Thermoregulation and physiological responses
- Exercise and Physiological Responses
- Sports Performance and Training
- Cardiovascular and exercise physiology
- Photoacoustic and Ultrasonic Imaging
- Cardiovascular Effects of Exercise
- Cardiac Valve Diseases and Treatments
- Cardiovascular and Diving-Related Complications
- Muscle metabolism and nutrition
- Advanced MRI Techniques and Applications
- Ultrasound Imaging and Elastography
- Hemodynamic Monitoring and Therapy
- Heart Rate Variability and Autonomic Control
- Forecasting Techniques and Applications
- Cardiovascular Health and Disease Prevention
- Climate Change and Health Impacts
- Ultrasound and Cavitation Phenomena
- Building Energy and Comfort Optimization
- Electrolyte and hormonal disorders
- Thermal Regulation in Medicine
- Artificial Intelligence in Healthcare and Education
- Infrared Thermography in Medicine
King's College London
2016-2023
The London College
2022
Cardiff Metropolitan University
2012-2020
St Thomas' Hospital
2020
Committee on Publication Ethics
2020
King's College School
2017
Thomas Jefferson University
2016
Nanyang Technological University
2013
DSO National Laboratories
2010-2012
National University of Singapore
2011
Short-term, high-altitude (HA) exposure raises pulmonary artery systolic pressure (PASP) and decreases left-ventricular (LV) volumes. However, relatively little is known of the long-term cardiac consequences prolonged in Sherpa, a highly adapted HA population. To investigate short-term adaptation potential remodeling, we studied ventricular structure function Sherpa at 5,050 m ( n = 11; 31 ± 13 yr; mass 68 10 kg; height 169 6 cm) lowlanders sea level (SL) following 3 days 9; 34 7 82 177...
The efficacy of ingestion ice slurry on actual outdoor endurance performance is unknown. This study aimed to investigate as a cooling intervention before 10 km running time-trial. Twelve participants ingested 8 g · kg<sup> − 1</sup> either ( 1.4°C; ICE) or ambient temperature drink (30.9°C; CON) and performed 15-min warm-up prior time-trial (Wet Bulb Globe Temperature: 28.2±0.8°C). Mean time was faster with ICE (2 715±396 s) than CON 730±385 s; P=0.023). Gastrointestinal (T<sub>gi</sub>)...
The measurement of cardiac and aortic pressures enables diagnostic insight into contractility stiffness. However, these are currently assessed invasively using pressure catheters. It may be possible to estimate less by applying microbubble ultrasound contrast agents as sensors. aim this study was investigate the subharmonic response agent SonoVue (Bracco Spa, Milan, Italy) at physiological a static phantom. A commercially available cell culture cassette with Luer connections used chamber....
There are no reported cases of exercise-associated hyponatremia (EAH) in tropical Asia. This study aimed to investigate the incidence EAH at on-site medical tent and fluid balance long distance foot races a warm humid environment. Body mass was taken before after (42-km marathon; 84-km ultra-marathon). Blood sodium concentration measured for symptomatic runners admitted tent. Mean (SD) dry bulb temperature 29.0 (0.6)°C, relative humidity 89 (2)% wind speed 0.3 (0.5) m/s. Three out 8 were...
There is limited information on the ingestion of cold drinks after exercise. We investigated thermoregulatory effects ingesting at 4°C (COLD) or 28°C (WARM) during work-rest cycles in heat. On 2 separate occasions, 8 healthy males walked treadmill for (45 min work; 15 rest) 5.5 km/h with 7.5% gradient. Two aliquots 400 mL plain water either were consumed each rest period. Rectal temperature (<i>T</i> <sub> <i> <i>re</i> </sub> </i> </sub>), skin <i>sk</i> <i/> heart rate and subjective...
Abstract Most rehydration studies prohibit fluid ingestion during the preceding bout of dehydrating exercise. However, an athlete using a widely researched carbohydrate‐electrolyte sports drink as nutritional strategy is likely to consume both and after exercise, warranting study design with administration test fluids exercise recovery. This further enhanced incorporation wind speed mimic outdoor conditions. Improved performance, usually extrapolated from improved recovery, was directly...
ABSTRACT Introduction Postmenopausal women have lower resting cardiac function than premenopausal women, but whether the menopause influences maximal output and hence exercise capacity is unclear. It possible that postmenopausal achieve similar improvements in aerobic (V˙O 2max ) with training via different regional left ventricular muscle (“LV mechanics”), as suggested by vitro animal studies. The aim of this study was to investigate effects on LV mechanics adaptations training. Methods...
Objectives: Cardiovascular function generally decreases with age, but whether this decrease differs between men and women is unclear. Our aims were twofold: (1) to investigate age-related sex differences in left ventricular (LV) structure, mechanics, (2) compare these measures pre- postmenopausal the middle-aged group.Methods: Resting echocardiography was performed a cross-sectional sample of 82 healthy adults (14 young men, 19 15 women, 34 women: premenopausal postmenopausal). Two-way...
Transvalvular pressure drops are assessed using Doppler echocardiography for the diagnosis of heart valve disease. However, this method is highly user-dependent and may overestimate transvalvular by up to 54%. This work aimed assess velocity fields derived from blood speckle imaging (BSI), as a potential alternative Doppler. METHODS: A silicone 3D-printed aortic model, segmented healthy CT scan, was placed within tube. CardioFlow 5000MR flow pump used circulate mimicking fluid create eight...
Several studies on Caucasian volunteers have proven that milk is an effective recovery drink for athletes. Such benefit, however, cannot be directly applied to the lactose-intolerant Asian population. This study investigated effects of ingesting water (WT), sports (SPD) and lactose-free (LFM) cycling capacity.Ten healthy young men completed 3 randomized experimental trials. Each trial consisted intermittent glycogen depleting session, a 2 h period during which they ingested test drink,...
Decisions in the management of aortic stenosis are based on peak pressure drop, captured by Doppler echocardiography, whereas gold standard catheterization measurements assess net drop but limited associated risks. The relationship between these two measurements, and is dictated recovery along ascending aorta which mainly caused turbulence energy dissipation. Currently, considered to occur within first 40-50 mm distally from valve, albeit there inconsistency across interventionist centers...
In response to recommendations redefine statistical significance p ≤ .005, we propose that researchers should transparently report and justify all choices they make when designing a study, including the alpha level.
It has been previously established that the subharmonic signal of microbubble ultrasound contrast agents follows an inverse linear relationship with ambient hydrostatic pressure. However, contradictory results have reported for SonoVue (Bracco Spa, Milan, Italy). Therefore, aim this study was to investigate response across a range physiologically-relevant pressures (10-220 mmHg), and compare it Sonazoid (GE, Oslo, Norway). A modified GE Logiq 9 scanner used acquire signals from in sealed...
Physiologically important pressures in the heart and aorta are currently assessed with invasive pressure catheters. The subharmonic signal from microbubble ultrasound contrast agents, however, may be exploited to estimate non-invasively. objective of this work was (i) develop a static phantom commercially-available components for easy replication across different laboratories, (ii) investigate response agent SonoVue (Bracco Spa, Milan, Italy) at physiological within phantom. A capable...
Physiologically important pressures in the heart and aorta are currently assessed with invasive pressure catheters. The subharmonic signal from ultrasound contrast agents, however, may be exploited to estimate non-invasively. objective of this work was (i) develop a static phantom commercially-available components for easy replication across different laboratories, (ii) investigate response agent SonoVue (Bracco, Milan, Italy) at physiological within phantom.
All previous studies on thermoregulation with the ingestion of a cold debt have been conducted in laboratory settings. PURPOSE: To investigate thermoregulatory responses and performance ice slurry before an outdoor 10 km running time trial heat (mean ± SD; WBGT: 28.3 0.5°C). METHODS: Thirteen healthy runners (nine males four females) completed full familiarisation run, followed by two experimental trials counterbalanced order, ingesting either 8 g/kg body mass or ambient temperature (30°C)...
Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main source(s): MRC. Background Cardiac catheterisation is the gold standard for assessing cardiac pressures. However, this an invasive and costly procedure. A minimally alternative may be to use subharmonic signal microbubble ultrasound contrast agents estimate pressure using echocardiography (Sub-Harmonic Assisted Pressure Estimation: SHAPE). Purpose The aim work was investigate ability SHAPE...
Subharmonic imaging (i.e., receiving signal at half the transmitting frequency) is a promising technique to detect ultrasound contrast agents in circulation. The aim of this study was characterize subharmonic enhancement four new microbubble formulations (MBF-1 4), compared with three commercially-available (Definity, Sonazoid and SonoVue), compare fundamental response. consisted either C3F8 or 2% C <sub xmlns:mml="http://www.w3.org/1998/Math/MathML"...
Cardiac catheterization is the gold standard for assessing cardiac pressures. However, this an invasive and costly procedure. An alternative may be to use subharmonic signal of microbubble ultrasound contrast agents estimate pressure using echocardiography. The aim work was investigate response agent SonoVue (Bracco Spa, Milan, Italy) dynamic pressures in a flow phantom. circulated through silicone tube peristaltic pump. ULtrasound Advanced Open Platform (ULA-OP) used with phased array...
Aortic stenosis is a condition which fatal if left untreated. Novel quantitative imaging techniques better characterise transvalvular pressure drops are being developed but require refinement and validation. A customisable cost-effective workbench valve phantom circuit capable of replicating mechanics pathology was created. The reproducibility relationship differing haemodynamic metrics were assessed from ground truth data alongside compatibility. met the requirements to capture ultrasound...