A5066448360- Cardiac Valve Diseases and Treatments
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Infective Endocarditis Diagnosis and Management
- Advanced MRI Techniques and Applications
- Pulmonary Hypertension Research and Treatments
- Cardiac Structural Anomalies and Repair
- Coronary Interventions and Diagnostics
- Cardiovascular and Diving-Related Complications
- Hemodynamic Monitoring and Therapy
- Medical Image Segmentation Techniques
- Congenital Heart Disease Studies
- Aortic Disease and Treatment Approaches
- Coronary Artery Anomalies
- Anesthesia and Neurotoxicity Research
- Health Policy Implementation Science
- Cardiac Arrhythmias and Treatments
- Cardiac Ischemia and Reperfusion
- Cardiovascular Issues in Pregnancy
- Mental Health Treatment and Access
- Cardiac tumors and thrombi
- Kawasaki Disease and Coronary Complications
- Advanced X-ray and CT Imaging
- Medical Imaging Techniques and Applications
- Aortic aneurysm repair treatments
St Thomas' Hospital
2022-2025
University of California, San Francisco
2024
King's College London
2002-2023
Guy's and St Thomas' NHS Foundation Trust
2021-2023
Background/Objectives: Sex-related differences in the presentation and outcomes of patients with mitral regurgitation (MR) undergoing valve (MV) surgery remain unclear. We aimed to identify these inform personalized management. Methods: A total 143 consecutive for MR between 2017 2018 were stratified by sex assessed characteristics. performed 1:1 propensity score matching (PSM) sex, baseline characteristics as covariates, yielding 38 comparable pairs which analyzed all-cause mortality...
Transvalvular pressure drops are assessed using Doppler echocardiography for the diagnosis of heart valve disease. However, this method is highly user-dependent and may overestimate transvalvular by up to 54%. This work aimed assess velocity fields derived from blood speckle imaging (BSI), as a potential alternative Doppler. METHODS: A silicone 3D-printed aortic model, segmented healthy CT scan, was placed within tube. CardioFlow 5000MR flow pump used circulate mimicking fluid create eight...
Decisions in the management of aortic stenosis are based on peak pressure drop, captured by Doppler echocardiography, whereas gold standard catheterization measurements assess net drop but limited associated risks. The relationship between these two measurements, and is dictated recovery along ascending aorta which mainly caused turbulence energy dissipation. Currently, considered to occur within first 40-50 mm distally from valve, albeit there inconsistency across interventionist centers...
Abstract Implementation of quality improvement (QI) initiatives within community mental health settings is crucial to addressing equity-related issues affecting services delivery, including for co-occurring substance use disorders. Given the growing recognition QI interventions as an effective framework facilitate structural change systems care, it important equip providers with knowledge and ability execute that are feasible, sustainable, integrate a equity lens. To demystify process, we...
Abstract OBJECTIVES Right ventricular-to-pulmonary artery (RV-PA) coupling has been associated with outcomes in mitral regurgitation (MR) treated by transcatheter approaches. We evaluated RV-PA as a predictor of survival and post-operative length hospital stay (LOS) patients undergoing valve (MV) surgery. METHODS In this retrospective analysis (median follow-up: 5.8 years), was quantified the ratio tricuspid annular plane systolic excursion to pulmonary pressure (TAPSE/PASP) using...
Transcatheter mitral therapies offer treatment options to selected patients who are unable undergo open procedures due prohibitive surgical risk. Data detailing the design and structure of transcatheter services ensure appropriate patient selection tailored management strategies is lacking. We report our initial experience developing running a purpose-built service. The nature number referral sources, multi-disciplinary make-up dedicated Mitral Heart Team use integrative imaging assessment...
Aortic stenosis is a condition which fatal if left untreated. Novel quantitative imaging techniques better characterise transvalvular pressure drops are being developed but require refinement and validation. A customisable cost-effective workbench valve phantom circuit capable of replicating mechanics pathology was created. The reproducibility relationship differing haemodynamic metrics were assessed from ground truth data alongside compatibility. met the requirements to capture ultrasound...
Brief periods of ischaemia activate systemic mechanisms that induce whole-body tolerance to subsequent prolonged and injurious ischaemia. This phenomenon, remote ischaemic preconditioning (RIPC), is sufficiently acute reduce ischaemia-reperfusion (IR) injury even when applied simultaneously with aspect RIPC termed postconditioning (RPostC). We have previously demonstrated a role for the autonomic nervous system in RIPC. Using an vivo model endothelial IR injury, we determined if RPostC...
Abstract Background Transvalvular pressure drops are assessed using Doppler echocardiography for the diagnosis of heart valve disease. However, this method is highly user-dependent and may overestimate transvalvular by up to 54%. This work aimed assess velocity fields derived from blood speckle imaging (BSI), as a potential alternative Doppler. Methods A silicone 3D-printed aortic model, segmented healthy CT scan, was placed within tube. CardioFlow 5000MR flow pump used circulate mimicking...
The aim of this study is to develop an automated method regional scar detection on clinically standard computed tomography angiography (CTA) using encoder-decoder networks with latent space classification.
Background: In patients with aortic stenosis (AS) and preserved left ventricular (LV) function, pre-intervention atrial (LA) enlargement is common predicts adverse events. Changes in LA function are appropriate markers of LV response to AS but have not been well explored undergoing TAVI. The objectives the current study were evaluate changes following TAVI their impact upon clinical outcomes. Methods: A total 313 consecutive included. There 160 (51%) paired echocardiographic datasets a...
Background: We aim to explore the determinants of right ventricular wall tension (RV base-to-apex length multiplied by systolic pulmonary artery pressure [RV WT] and association with all-cause mortality in patients moderate-to-severe tricuspid regurgitation. Materials & methods: Of total, 180 (71 ± 15 years, 54% females) were included. An increased RV WT was defined as >3300 mmHg x mm. Results: Patients (n = 85, 47%) more likely be male taller than normal WT. In a multivariable-adjusted...