A5016734550- Cardiac pacing and defibrillation studies
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Neurological disorders and treatments
- Cardiac Imaging and Diagnostics
- Cardiac Structural Anomalies and Repair
- Cardiovascular Function and Risk Factors
- Advanced MRI Techniques and Applications
- Atrial Fibrillation Management and Outcomes
- Advanced X-ray and CT Imaging
- Cardiovascular Health and Disease Prevention
- Cardiovascular Disease and Adiposity
- Quality and Safety in Healthcare
- Voice and Speech Disorders
- Cardiomyopathy and Myosin Studies
- Cardiac Valve Diseases and Treatments
- COVID-19 diagnosis using AI
- Acute Ischemic Stroke Management
- Phonocardiography and Auscultation Techniques
- ECG Monitoring and Analysis
- Cerebrovascular and Carotid Artery Diseases
- Vascular anomalies and interventions
- Impact of AI and Big Data on Business and Society
- Bone fractures and treatments
- Frailty in Older Adults
King's College London
2020-2024
Guy's and St Thomas' NHS Foundation Trust
2020-2024
St Thomas' Hospital
2020-2024
University of Hull
2022-2024
North Shore University Hospital
2024
Government Medical College Bhavnagar
2022
Marymount University
2022
University Teaching Hospital
2022
Barnet Hospital
2019
Lewisham and Greenwich NHS Trust
2018
Conduction system pacing (CSP), in the form of His bundle (HBP) or left branch (LBBP), is emerging as a valuable cardiac resynchronization therapy (CRT) delivery method. However, patient selection and personalization for CSP remain poorly characterized. We aim to compare pacing-induced electrical synchrony during CRT, HBP, LBBP, HBP with ventricular (LV) epicardial lead (His-optimized CRT [HOT-CRT]), LBBP LV (LBBP-optimized [LOT-CRT]) patients different conduction disease presentations using...
His-bundle pacing (HBP) and left bundle (LBP) are emerging as novel delivery methods for cardiac resynchronization therapy (CRT) in heart failure patients with branch block (LBBB). HBP LBP have never been compared to biventricular endocardial (BiV-endo) pacing. Furthermore, there indications of negative effects on right ventricular (RV) activation times (ATs), but these not quantified.The purpose this study was compare changes induced by HBP, LBP, (LV) septal pacing, BiV-endo, epicardial...
Abstract Aims Transvenous lead extraction is associated with a significant risk of complications and identifying patients at highest pre-procedurally will enable interventions to be planned accordingly. We developed the ELECTRa Registry Outcome Score (EROS) applied it registry determine if could appropriately risk-stratify patients. Methods results EROS was devised into low (EROS 1), intermediate 2), high 3). This ESC EORP European Lead Extraction ConTRolled registry; 57.5% 1, 31.8% 2, 10.7%...
We present a novel multimodal deep learning framework for cardiac resynchronisation therapy (CRT) response prediction from 2D echocardiography and magnetic resonance (CMR) data. The proposed method first uses the 'nnU-Net' segmentation model to extract segmentations of heart over full cycle two modalities. Next, classifier is used CRT prediction, which combines latent spaces models At test time, this can be with data only, whilst taking advantage implicit relationship between CMR features...
Antimicrobial envelopes reduce the incidence of cardiac implantable electronic device infections, but their cost restricts routine use in United Kingdom. Risk scoring could help to identify which patients would most benefit from this technology.
Biventricular endocardial pacing (BiV-endo) has demonstrated superior cardiac resynchronization compared to conventional biventricular epicardial (BiV-epi). Left bundle branch area (LBBAP) may also achieve effective therapy (CRT).The purpose of this study was compare the acute electrical and hemodynamic effects BiV-epi, BiV-endo, LBBAP delivered from LV endocardium assess how myocardial scar affects response.Eleven patients with heart failure indications for CRT underwent a temporary...
Background The value of screening sub‐clinical atherosclerosis in asymptomatic patients with type 2 diabetes mellitus (T2DM) remains controversial. Hypothesis An integrated model incorporating carotid intima‐media thickness (CIMT) and plaque traditional risk factors can be used to predict prevalence severity coronary artery calcification T2DM patients. Methods A cohort 262 were prospectively studied ultrasound evaluate CIMT also a computed tomography calcium (CT‐CAC) scan. Results Carotid...
No periprocedural metric has demonstrated improved cardiac resynchronization therapy (CRT) outcomes in a multicenter setting.We sought to determine if left ventricular (LV) lead placement targeted the coronary sinus (CS) branch generating best acute hemodynamic response (AHR) results at 6 months.In this randomized controlled trial, patients were guided CRT or conventional CRT. Patients arm had LV dP/dtmax measured during biventricular (BIV) pacing. Target CS branches identified and final...
Long-term outcomes are poorly understood, and data in patients undergoing transvenous lead extraction (TLE) lacking.The purpose of this study was to evaluate factors influencing survival TLE depending on indication.Clinical from consecutive the reference center between 2000 2019 were prospectively collected. The total cohort divided into groups whether there an infective or noninfective indication for TLE. We evaluated association demographic, clinical, device-related procedure-related...
Abstract Aims Transvenous lead extraction (TLE) should ideally be undertaken by experienced operators in a setting that allows urgent surgical intervention. In this analysis of the ELECTRa registry, we sought to determine whether there was significant difference procedure complications and mortality depending on centre volume location. Methods results Analysis ESC EORP European Lead Extraction ConTRolled registry conducted. Low-volume (LoV) centres were defined as <30 procedures/year,...
A 63-year-old patient with ischemic cardiomyopathy, severe left ventricular systolic dysfunction, atrial fibrillation underlying complete heart block, and a conventional cardiac resynchronization therapy-defibrillator (CRT-D), was diagnosed device-related infection. This device
Abstract Aims Cardiac resynchronization therapy (CRT) upgrades may be less likely to improve following intervention. Leadless left ventricular (LV) endocardial pacing has been used for patients with previously failed CRT or high-risk upgrades. We compared procedural and long-term outcomes in undergoing coronary sinus (CS) LV Method results Prospective consecutive CS between 2015 2019 were those WiSE-CRT implantation. response at 6 months was defined as improvement clinical composite score...
Quantifying uncertainty of predictions has been identified as one way to develop more trustworthy artificial intelligence (AI) models beyond conventional reporting performance metrics. When considering their role in a clinical decision support setting, AI classification should ideally avoid confident wrong and maximise the confidence correct predictions. Models that do this are said be well calibrated with regard confidence. However, relatively little attention paid how improve calibration...
BackgroundEpicardial pacing increases risk of ventricular tachycardia (VT) in patients with ischemic cardiomyopathy (ICM) when proximity to scar. Endocardial may be less arrhythmogenic as it preserves the physiological sequences activation and repolarization.ObjectiveThe purpose this study was determine relative endocardial compared epicardial pacing, role transmural gradient action potential duration (APD) location scar on during pacing.MethodsComputational models ICM (n = 24) were used...
Left bundle branch area pacing (LBBAP) is a novel form of conduction system which can reverse left block and deliver cardiac resynchronization therapy (CRT). The WiSE-CRT delivers leadless endocardial with symptomatic ventricular (LV) remodelling improvements following intervention. We report the technical feasibility delivering LBBAP using system.In Case 1, 57-year-old male ischaemic cardiomyopathy complete heart underwent implantation system, retrograde transaortic approach, after failed...