A5105038820- Cell Adhesion Molecules Research
- Nanoplatforms for cancer theranostics
- Fibroblast Growth Factor Research
- Immune cells in cancer
- Angiogenesis and VEGF in Cancer
- Pancreatic function and diabetes
- Protein Degradation and Inhibitors
- Proteoglycans and glycosaminoglycans research
- Autophagy in Disease and Therapy
Chinese Academy of Sciences
2024-2025
Shenzhen Institutes of Advanced Technology
2024-2025
Sichuan University
2010
The Dll4-Notch signaling pathway plays a crucial role in the regulation of angiogenesis and is promising therapeutic target for diseases associated with abnormal angiogenesis, such as cancer ophthalmic diseases. Here, we find that polyethylenimine (PEI), cationic polymer widely used nucleic acid transfection reagents, can Notch ligand Dll4. By immunostaining immunoblotting, demonstrate PEI significantly induces clearance cell-surface Dll4 facilitates its degradation through lysosomal...