A5028279197- SARS-CoV-2 and COVID-19 Research
- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- COVID-19 Clinical Research Studies
- Immunotherapy and Immune Responses
- Virus-based gene therapy research
- Iron Metabolism and Disorders
- Hemoglobinopathies and Related Disorders
- Trace Elements in Health
- interferon and immune responses
- High-Voltage Power Transmission Systems
- Epigenetics and DNA Methylation
- Herpesvirus Infections and Treatments
- Heme Oxygenase-1 and Carbon Monoxide
- Smart Grid and Power Systems
- Ferroptosis and cancer prognosis
- Vacuum and Plasma Arcs
- vaccines and immunoinformatics approaches
Hebei Normal University
2024
Dalian Municipal Central Hospital
2024
University of Chinese Academy of Sciences
2020-2022
Institute of Microbiology
2020-2022
Chinese Academy of Sciences
2020-2022
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of recent pandemic COVID-19, is reported to have originated from bats, with its intermediate host unknown date. Here, we screened 26 animal counterparts human ACE2 (hACE2), receptor for SARS-CoV-2 and SARS-CoV, found that ACE2s various species, including pets, domestic animals multiple wild animals, could bind binding domain (RBD) facilitate transduction pseudovirus. Comparing SARS-CoV-2, SARS-CoV seems a...
Abstract The rapid expansion of the COVID-19 pandemic has made development a SARS-CoV-2 vaccine global health and economic priority. Taking advantage versatility development, three mRNA candidates have entered clinical trials with two-dose immunization regimen. However, waning antibody response in convalescent patients after infection emergence human re-infection raised widespread concerns about possible short duration protection. Here, we developed nucleoside-modified lipid-encapsulated...
Herpes zoster (HZ), also known as shingles, remains a significant global health issue and most commonly seen in elderly individuals with an early exposure history to varicella-zoster virus (VZV). Currently, the licensed vaccine Shingrix, which comprises recombinant VZV glycoprotein E (gE) formulated potent adjuvant AS01B, is effective shingles on market. However, undesired reactogenicity increasing demand causing shortage, prompting development of novel vaccines. Here, we developed...
Summary Background A safe and effective coronavirus disease 2019 (COVID-19) vaccine is urgently needed to control the ongoing pandemic. Although progress has been made recently with several candidates reporting positive efficacy results, COVID-19 vaccines developed so far cannot meet global demand. We a protein subunit against COVID-19, using dimeric form of receptor-binding domain (RBD) as antigen. aimed assess safety immunogenicity this in humans determine appropriate dose schedule for an...
Abstract Transmembrane serine protease 6 (Tmprss6) has been correlated with the occurrence and progression of tumors, but any specific molecular mechanism linking enzyme to oncogenesis remained elusive thus far. In present study, we found that Tmprss6 markedly inhibited mouse neuroblastoma N2a (neuro-2a) cell proliferation tumor growth in nude mice. inhibits Smad1/5/8 phosphorylation by cleaving bone morphogenetic protein (BMP) co-receptor, hemojuvelin (HJV). Ordinarily, phosphorylated binds...
<title>Abstract</title> Emerging evidences have suggested that ferroptosis is one of the targeted mechanisms in tumor therapy. However, whether erastin can induce acute myeloid leukemia (AML) and potential remains to be explored. CCK8 assay was first used detect toxicity human promyelocytic cells (HL60), toxicological effect on HL60 performed a significant dose-dependent manner. Ferroptosis affirmed through manifestation mitochondrial ultrastructural damage, accumulation reactive oxygen...
A Correction to this paper has been published: https://doi.org/10.1038/s41467-021-22820-x
Abstract Since the first report on November 24, 2021, Omicron SARS-CoV-2 variant is now overwhelmingly spreading across world. Two inactivated vaccines (IAVs), one recombinant protein subunit vaccine (PRV), and adenovirus-vectored (AdV) have been widely administrated in many countries including China to pursue herd immunity. Here we investigated cross-neutralizing activities 341 human serum specimens elicited by full-course vaccinations with IAV, PRV AdV, various boosters following prime IAV...
Abstract The rapid expansion of COVID-19 pandemic has made the development a SARS-CoV-2 vaccine global health and economic priority. Taking advantages versatility development, three mRNA candidates entered clinical trials with two-dose immunization regimen. However, waning antibodies response in convalescent patients after infection emergence human re-infection have raised widespread concern about short duration protection. Here, we developed nucleoside-modified lipid-encapsulated form which...