A5102818110- Respiratory viral infections research
- Influenza Virus Research Studies
- Viral gastroenteritis research and epidemiology
- Animal Disease Management and Epidemiology
- Congenital Diaphragmatic Hernia Studies
- Bacteriophages and microbial interactions
- interferon and immune responses
- Viral Infections and Vectors
- Heavy Metal Exposure and Toxicity
- Virus-based gene therapy research
- Advanced biosensing and bioanalysis techniques
- Mercury impact and mitigation studies
- Immune Response and Inflammation
- Yersinia bacterium, plague, ectoparasites research
- Vibrio bacteria research studies
- Nanopore and Nanochannel Transport Studies
- RNA modifications and cancer
- Neonatal Respiratory Health Research
- SARS-CoV-2 detection and testing
- RNA and protein synthesis mechanisms
- vaccines and immunoinformatics approaches
- Gout, Hyperuricemia, Uric Acid
- Ethnobotanical and Medicinal Plants Studies
- Herpesvirus Infections and Treatments
- Salmonella and Campylobacter epidemiology
Hangzhou Center for Disease Control and Prevention
2010-2022
Zhejiang Center for Disease Control and Prevention
2015-2021
Centers for Disease Control and Prevention
2010-2014
Chinese Center For Disease Control and Prevention
2007
Avian influenza virus A of the novel H7N9 reassortant subtype was recently found to cause severe human respiratory infections in China. Live poultry markets were suspected locations infection sources, based on cases' exposure histories and sequence similarities between viral isolates. To explore role live origin virus, we systematically examined environmental specimens from local farms Hangzhou, using real-time reverse transcription-PCR (RT-PCR) as well high-throughput next-generation...
The total phenolic and flavonoid, antioxidant antibacterial activities of six Sonchus wild vegetables (Sonchus oleraceus L., arvensis asper (L.) Hill., uliginosus M.B., brachyotus DC. lingianus Shih) in China were investigated. results revealed that S. extract contained the highest amount respectively. Among methanol extracts species, exhibited radical (DPPH ABTS+ scavenging power lipid peroxidation inhibitory power. It also reducing at 500 µg mL⁻¹ by A (700) = 0.80. test indicated showed...
A novel H7N9 influenza virus has been discovered as the causative identity of emerging acute respiratory infection cases in Shanghai, China. This also identified neighboring area Hangzhou City Zhejiang Province. In this study, epidemiologic, clinical, and virological data from three patients who were confirmed to be infected by collected analyzed. Human specimens chicken feces a contacted free market tested for real-time reverse transcription PCR (RT-PCR) sequencing. The clinical features...
Uric acid metabolic disorder is considered to be the main pathogenesis of uric nephropathy (UN). Smilax glabra Roxb. a traditional Chinese herb which has been used in treatment gout, but mechanism was unclear. In this study, we investigated protective effects flavonoid-rich fraction from rhizomes (SGF) on rats and its underlying mechanisms promoting excretion. Sprague Dawley (SD) were induced by high purine diet (yeast pellets + adenine) for 5 weeks. Rats orally treated with SGF or...
A conjugative plasmid, pMRV150, which mediated multiple-drug resistance (MDR) to at least six antibiotics, including ampicillin, streptomycin, gentamicin, tetracycline, chloramphenicol, and trimethoprim-sulfamethoxazole, was identified in a Vibrio cholerae O139 isolate from Hangzhou, eastern China, 2004. According partial pMRV150 DNA sequences covering 15 backbone regions, the plasmid is most similar pIP1202, an IncA/C MDR Yersinia pestis Madagascar bubonic plague patient, identity of 99.99%...
The novel SARS-CoV-2 outbreak has swiftly spread worldwide. rapid genome sequencing of strains become a helpful tool for better understanding the genomic characteristics and origin virus. To obtain virus whole-genome sequences directly from clinical specimens, we performed nanopore using modified ARTIC protocol in portable sequencer validated routine 8-h workflow 5-h pipeline. We conducted some optimization to improve workflow. sensitivity was also tested by serially diluting RNA samples....
ABSTRACT Adenovirus serotype 3 and 7 outbreaks have occurred periodically in northern, eastern, southern China since 1955, but there has been no report the adenovirus outbreak first Hangzhou, China, 1991. Here we explored epidemiology etiology of two Hangzhou 2011. One acute respiratory was found Chun'an County, where a total 371 cases were confirmed 5 23 towns from 4 to 31 May The affected 18.57% (13/70) schools 14.49% (90/621) classes. incidence 5.18% (371/7,163). population distributed...
Lead (Pb) is an important environmental pollutant. Oxidative stress and the inflammatory response have been postulated as mechanisms involved in lead-induced renal damage. Smilax glabra Roxb. has used for treatment of heavy-metal poisoning China 500 years. We investigated S. flavonoids extract (SGF) could attenuate lead acetate-induced nephrotoxicity weaning rats human embryonic kidney (HEK)-293 cells, possible mechanisms. Compared with Pb exposed group rats, SGF significantly promote...
Significance Deep-sequencing of viral genomes based on original specimens from H7N9-infected patients and the surrounding poultry/environment has provided first in-depth data virus adaptation at interface between poultry humans. In contrast to consistent dominance 627E in poultry-derived H7N9, diverse but longitudinally changing ratios mammalian signature substitution PB2-E627K patient indicate a dynamic during infection, termed “genetic tuning” avian influenza viruses new hosts....
To investigate the anti-obesity and hypolipidemic effects of Alpinia officinarum ethanolic extract (AOE) for first time, models in vivo were used. Ten male Sprague-Dawley rats fed normal control diet (NC); other groups a high-fat (HFD) with or without different proportions AOE (AOE-1, 3%; AOE-2, 5%) 6 weeks to examine feed intake, body adipose tissue weight, serum total cholesterol (Total-C), triacylglycerol (TG), high-density lipoprotein (HDL-C), low-density (LDL-C), leptin levels, alanine...
ABSTRACT The novel H7N9 avian influenza virus (AIV) was demonstrated to cause severe human respiratory infections in China. Here, we examined poultry specimens from live bird markets linked infection Hangzhou, Metagenomic sequencing revealed mixed subtypes (H5, H7, H9, N1, N2, and N9). Subsequently, AIV H5N9, H7N9, H9N2 were isolated. Evolutionary analysis showed that the hemagglutinin gene of H5N9 originated A/Muscovy duck/Vietnam/LBM227/2012 (H5N1), which belongs clade 2.3.2.1....
During July to November 2017, a large dengue outbreak involving 1,138 indigenous cases occurred in Hangzhou, Zhejiang Province, China. All patients were clinically diagnosed as mild dengue. Epidemiology investigation and phylogenetic analysis of circulating viruses revealed that at least three lineages virus serotype 2 (DENV-2) Cosmopolitan genotype initiated the during short time. The time most recent common ancestor estimated putative these DENV-2 might rise no later than March, suggesting...
Abstract The outbreak of the novel SARS-CoV-2 has swiftly spread worldwide. Rapid genome sequencing strains become a helpful tool for better understanding virus genomic characteristics and origin. To obtain whole-genome sequence directly from clinical specimens, we performed nanopore using modified ARTIC protocol on portable sequencer, validated routine 8 hours workflow 5 rapid pipeline. We had made some optimizations to improve workflow. sensitivity was also tested by serially diluting RNA...
Vaccine efficacy (VE) can be affected by progressive antigenic drift or any new reassortment of influenza viruses. To effectively track the evolution human A(H3N2) virus circulating in Hangzhou, China, a total 65 clinical specimens were selected randomly from outpatients infected viruses during study period November 2009 to December 2013. The results reduced VE and correspondent epitopes (C-D-E A-B) suggest that current vaccine provides suboptimal protection against strains recently....