A5101787754- Pluripotent Stem Cells Research
- CRISPR and Genetic Engineering
- Advanced battery technologies research
- Supercapacitor Materials and Fabrication
- Viral Infections and Vectors
- Advancements in Battery Materials
- Target Tracking and Data Fusion in Sensor Networks
- Mosquito-borne diseases and control
- Genetic Neurodegenerative Diseases
- Virology and Viral Diseases
- Statistical Methods and Inference
- Semantic Web and Ontologies
- 3D Printing in Biomedical Research
- Biomedical Ethics and Regulation
- Malaria Research and Control
- Microtubule and mitosis dynamics
- Infective Endocarditis Diagnosis and Management
- Respiratory viral infections research
- Reinforcement Learning in Robotics
- Advanced Battery Materials and Technologies
- Water Systems and Optimization
- Bayesian Modeling and Causal Inference
- RNA Interference and Gene Delivery
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
Qingdao University
2023-2024
Fujian Medical University
2024
State Key Laboratory of Stem Cell and Reproductive Biology
2017-2019
Institute of Zoology
2013-2019
University of Chinese Academy of Sciences
2015-2018
Chinese Academy of Sciences
2013-2018
North China Electric Power University
2017-2018
Mutation for microcephaly Zika virus infections in humans have been known since 1947. Microcephaly and neuropathologies associated with only reported recently, most prevalently the Americas. Yuan et al. investigated recent stable mutations genome engineered them into a low-virulence ancestral strain (see Perspective by Screaton Mongkolsapaya). A single amino acid substitution (serine to asparagine, S139N) viral precursor membrane protein exacerbated symptoms pregnant mice. The reverse...
Abstract Aqueous zinc‐ion batteries (ZIBs) enjoy a good reputation for being safe, affordable to produce, and ecologically friendly due the use of water‐based electrolytes. The main factors restricting development ZIBs, however, are negative effects dendrite deposition on zinc anode dissolution common cathodes such as Mn V‐based cathodes. Various techniques have been used address these issues, including regulating electrolyte concentration or solvation structure, developing coating current...
Abstract The challenge with aqueous zinc‐ion batteries (ZIBs) lies in finding suitable cathode materials that can provide high capacity and fast kinetics. Herein, two‐dimensional topological Bi 2 Se 3 acceptable Bi‐vacancies for ZIBs (Cu‐Bi 2−x ) is constructed through one‐step hydrothermal process accompanied by Cu heteroatom introduction. cation‐deficient Cu‐Bi nanosheets (≈4 nm) bring improved conductivity from large surface metal states contribution enhanced bulk conductivity. Besides,...
Resolving the sluggish transport kinetics of divalent Zn
Clinical application of stem cell derivatives requires clinical-grade cells and sufficient preclinical proof safety efficacy, preferably in primates. We previously successfully established a human parthenogenetic embryonic (hPESC) line, but the suitability its subtype-specific progenies for therapy is not clear. Here, we compared function hPESC-derived midbrain dopaminergic (DA) neurons two canonical protocols primate Parkinson's disease (PD) model. found that grafts did form tumors produced...
Differentiation of human pluripotent stem cells (hPSCs) into striatal medium spiny neurons (MSNs) promises a cell-based therapy for Huntington's disease. However, clinical-grade MSNs remain unavailable. Here, we developed chemical recipe named XLSBA to generate from embryonic (ESCs). We introduced the γ-secretase inhibitor DAPT accelerate neural differentiation, and replaced protein components with small molecules. Using this optimized protocol could efficiently direct regular ESCs (hESCs)...
To investigate the role and related mechanisms of LiaSR two-component system in acid tolerance biofilm formation abilities
Generation of induced pluripotent stem cells (iPSCs) requires a considerable amount lipids, such as phosphatidic acid (PA), to meet the needs subsequent rapid cell division and proliferation. However, it is unclear whether PA, biosynthetic precursor affects reprogramming. By using lentiviral expression Yamanaka factors in mouse embryonic fibroblasts for reprogramming, we identified that PA beneficial generation iPS colonies. Inhibiting cellular dramatically decreased number iPSCs....
Tracking maneuvering target is a challenging problem and Interactive Multiple Model (IMM) proved an effective solution for it. In multiple model, the constant turn model (CT) usually used to describe target's turning motion. However, fixed or partially adaptive angular rate μ adopted in CT which leads tracking accuracy decrease. this paper, improved interactive set based on self-adaptive proposed. value of ω calculated both x y velocity instead only one them value. To verify improvement,...
Causal discovery, the task of inferring causal structure from data, promises to accelerate scientific research, inform policy making, and more. However, per-dataset nature existing discovery algorithms renders them slow, data hungry, brittle. Inspired by foundation models, we propose a framework where deep learning model is pretrained resolve predictions classical run over smaller subsets variables. This method enabled observations that outputs are fast compute for small problems,...
Rationally identifying variables responsible for changes to a biological system can enable myriad applications in disease understanding and cell engineering. From causality perspective, we are given two datasets generated by the same causal model, one observational (control) interventional (perturbed). The goal is isolate subset of measured (e.g. genes) that were targets intervention, i.e. those whose conditional independencies have changed. Knowing graph would limit search space, allowing...
Bronchiolitis is a common lower respiratory tract infection in infants and young children. Severe cases may be accompanied by obvious dyspnea oxygen saturation decline.To summarize the clinical features, standard diagnosis, treatment of bronchiolitis.This retrospective analysis 114 pediatric patients (74 males, 40 females) who were first diagnosed as having bronchioles at Department Pediatrics Tongling Maternal Child Health Hospital from January 2019 to December 2019. The imaging treatment,...
Particle impoverishment, which always leads to accuracy decreasing, is a classical problem of the traditional particle filter resampling. A resampling method based on improved genetic algorithm proposed in this paper solve problem. In algorithm, step applied for reproduction. The main work include two parts. first one calculating dynamically changed crossover probability and mutation used decide whether will be carried out. second part adopting Euclidean distances predicted particles as...