A5103251150- Mosquito-borne diseases and control
- Viral Infections and Vectors
- interferon and immune responses
- Virology and Viral Diseases
- Animal Virus Infections Studies
- Plant Virus Research Studies
- Ubiquitin and proteasome pathways
- Hepatitis C virus research
- Viral gastroenteritis research and epidemiology
- Herpesvirus Infections and Treatments
- Vector-borne infectious diseases
- Signaling Pathways in Disease
- Malaria Research and Control
- RNA Interference and Gene Delivery
- Insect symbiosis and bacterial influences
- Hepatitis B Virus Studies
- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Immunology Research
Wuhan Institute of Virology
2017-2023
Chinese Academy of Sciences
2017-2023
University of Chinese Academy of Sciences
2019-2023
Mosquito-borne flaviviruses infect both mammals and mosquitoes. RNA interference (RNAi) has been demonstrated as an anti-flavivirus mechanism in mosquitoes; however, whether how induce antagonize RNAi-mediated antiviral immunity remains unknown. We show that the nonstructural protein NS2A of dengue virus-2 (DENV2) act a viral suppressor RNAi (VSR). When NS2A-mediated suppression was disabled, resulting mutant DENV2 induced Dicer-dependent production abundant DENV2-derived siRNAs...
RNA interference (RNAi) is a well-established antiviral immunity. However, for mammalian somatic cells, RNAi becomes evident only when viral suppressors of (VSRs) are disabled by mutations or VSR-targeting drugs, thereby limiting its scope as We find that wild-type alphavirus, Semliki Forest virus (SFV), triggers the Dicer-dependent production virus-derived small interfering RNAs (vsiRNAs) in both cells and adult mice. These SFV-vsiRNAs located at particular region within 5' terminus SFV...
RNA interference (RNAi) is a conserved antiviral immune defense in eukaryotes, and numerous viruses have been found to encode viral suppressors of RNAi (VSRs) counteract RNAi. Alphaviruses are large group positive-stranded that maintain their transmission life cycles both mosquitoes mammals. However, there little knowledge about how alphaviruses antagonize host organisms. In this study, we identified Semliki Forest virus (SFV) capsid protein can efficiently suppress insect mammalian cells by...
The N-end rule pathway is an evolutionarily conserved proteolytic system that degrades proteins containing N-terminal degradation signals called N-degrons, and has emerged as a key regulator of various processes. Viruses manipulate diverse host pathways to facilitate viral replication evade antiviral defenses. However, it remains unclear if infection any impact on the pathway. Here, using picorna-like virus model, we found promoted accumulation caspase-cleaved Drosophila inhibitor apoptosis...
Rubella virus (RuV) is the infectious agent of a series birth defect diseases termed congenital rubella syndrome, which major public health concern all around world. RNA interference (RNAi) crucial antiviral defense mechanism in eukaryotes, and numerous viruses have been found to encode viral suppressors RNAi (VSRs) evade response. However, there little knowledge about whether how RuV antagonizes RNAi. In this study, we identified that capsid protein potent VSR can efficiently suppress...
RNA-remodelling proteins, including RNA helicases and chaperones, function to remodel structured RNAs and/or RNA–protein interactions play indispensable roles in viral life cycles. Guaico Culex virus (GCXV) is the first uncovered animal-infected multicomponent with segmented positive-sense genomic RNAs. GCXV belongs Jingmenvirus group, a diverse clade of viruses that are related prototypically unsegmented Flavivirus . However, little known about exact functions GCXV-encoded proteins. Here,...