Kushalinii Hillson
A5019048731- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- SARS-CoV-2 and COVID-19 Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pharmaceutical studies and practices
- Pediatric health and respiratory diseases
- COVID-19 Clinical Research Studies
- COVID-19 Impact on Reproduction
- Tracheal and airway disorders
- Chronic Disease Management Strategies
- Retinal and Optic Conditions
- Vaccine Coverage and Hesitancy
- Pregnancy and Medication Impact
- Bacterial Infections and Vaccines
- Ethics in Clinical Research
- Gastroesophageal reflux and treatments
- Heparin-Induced Thrombocytopenia and Thrombosis
- Injury Epidemiology and Prevention
- Pregnancy and preeclampsia studies
Imperial College London
2024-2025
Royal Brompton Hospital
2024-2025
Harefield Hospital
2024
Science Oxford
2023
Churchill Hospital
2022-2023
Royal London Hospital
2022-2023
University of Oxford
2021-2023
Barts Health NHS Trust
2022
SummaryBackgroundCOVID-19 vaccine supply shortages are causing concerns about compromised immunity in some countries as the interval between first and second dose becomes longer. Conversely, with no constraints considering administering a third dose. We assessed persistence of immunogenicity after single ChAdOx1 nCoV-19 (AZD1222), an extended (44–45 weeks) dose, response to booster given 28–38 weeks dose.MethodsIn this substudy, volunteers aged 18–55 years who were enrolled phase 1/2...
BackgroundVaccination of children and young people against SARS-CoV-2 is recommended in some countries. Scarce data have been published on immune responses induced by COVID-19 vaccines younger than 18 years compared with the same that are available adults.MethodsCOV006 a phase 2, single-blind, randomised, controlled trial ChAdOx1 nCoV-19 (AZD1222) adolescents at four sites UK. Healthy participants aged 6–17 years, who did not history chronic respiratory conditions, laboratory-confirmed...
ABSTRACT Background Post hoc analysis of clinical trials shows blood eosinophil counts (BEC) predict future preschool wheeze attacks; however, prospective usefulness in a setting is unreported. We assessed the feasibility point‐of‐care (POC) measurements wheezers and related BEC to symptoms, lung function, utility predicting attacks. Methods Children aged 1–5 years with recurrent underwent finger‐prick sampling during outpatient clinic for POC eosinophils, forced oscillation technique (FOT)...
<h3>Background</h3> <i>Post hoc</i> analysis of clinical trials has shown that blood eosinophils may predict future preschool wheeze attacks, however, the optimal cut-off and utility in a setting is uncertain. <h3>Hypothesis</h3> Point-of-care (POC) eosinophil measurements wheezers relate to symptoms lung function attacks. <h3>Methods</h3> Children aged 1–5 years with recurrent underwent finger-prick sampling for POC eosinophils. Forced oscillation technique (FOT) using 8Hz protocol and/or...
A causal link between gastroesophageal reflux disease (GORD) and respiratory symptoms is unclear. The 2019 CHEST guideline recommends GORD treatment only in the context of clinical symptoms, signs or a positive test. We evaluated feasibility 24-hour ambulatory impedance testing as minimally invasive test to identify contributing symptoms. Our centre performs flexible bronchoscopy pH-Multichannel intraluminal (pH-Mii™) probe placement under general anaesthesia part assessment complex...
<h3>Aims</h3> <h3>Background</h3> Acute asthma exacerbations are common in children, with consequent strain on NHS services. Self-management education incorporating personalised action plans (PAAP) can improve outcomes, particularly preschoolers and ethnic minorities. The British Thoracic Society (BTS) guideline<sup>1</sup> recommends that inpatients should receive a PAAP prior to discharge, each admission presents both risk self-management educational opportunity. To assess compliance the...