A5023145404- Asthma and respiratory diseases
- Inhalation and Respiratory Drug Delivery
- Respiratory and Cough-Related Research
- Child and Adolescent Health
- Mast cells and histamine
- Hepatitis C virus research
- Infant Development and Preterm Care
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Allergic Rhinitis and Sensitization
- HIV-related health complications and treatments
- HIV Research and Treatment
- Pulmonary Hypertension Research and Treatments
- Chronic Disease Management Strategies
- Neonatal Respiratory Health Research
- Patient Satisfaction in Healthcare
- Adolescent and Pediatric Healthcare
- Hospital Admissions and Outcomes
- Childhood Cancer Survivors' Quality of Life
- Eosinophilic Esophagitis
- Pediatric health and respiratory diseases
- Vascular Anomalies and Treatments
- Cervical Cancer and HPV Research
- Immunotherapy and Immune Responses
- Hepatitis B Virus Studies
- Injury Epidemiology and Prevention
Imperial College London
2009-2025
Royal Brompton Hospital
2020-2024
Lung Institute
2020-2023
King's College Hospital NHS Foundation Trust
2019
National Health Service
2019
North Middlesex University Hospital NHS Trust
2011
Inserm
2009
University of Silesia in Katowice
2009
Medical University of Silesia
2009
Allergic asthma generally starts during early life and is linked to substantial tissue remodeling lung dysfunction. Although angiogenesis a feature of the disrupted airway, impact allergic on pulmonary microcirculation unknown. Here, using quantitative imaging in precision-cut slices (PCLSs), we report that exposure neonatal mice house dust mite (HDM) extract disrupts endothelial cell/pericyte interactions adventitial areas. Central blood vessel structure, loss pericyte coverage was driven...
ABSTRACT Background Post hoc analysis of clinical trials shows blood eosinophil counts (BEC) predict future preschool wheeze attacks; however, prospective usefulness in a setting is unreported. We assessed the feasibility point‐of‐care (POC) measurements wheezers and related BEC to symptoms, lung function, utility predicting attacks. Methods Children aged 1–5 years with recurrent underwent finger‐prick sampling during outpatient clinic for POC eosinophils, forced oscillation technique (FOT)...
Summary. Central nervous system (CNS) manifestations of chronic hepatitis C virus (HCV) and human immune deficiency virus-1 (HIV-1) infections have been reported, but the impact acute HCV infection on CNS is unknown. A total 10 individuals with stable HIV-1 documented (HCV-RNA polymerase chain reaction positive antibody negative, group 1) underwent cerebral proton magnetic resonance spectroscopy (MRS) using acquisition parameters to quantify myo-inositol/creatine (mI/Cr) ratio in right basal...
<h3>Background</h3> <i>Post hoc</i> analysis of clinical trials has shown that blood eosinophils may predict future preschool wheeze attacks, however, the optimal cut-off and utility in a setting is uncertain. <h3>Hypothesis</h3> Point-of-care (POC) eosinophil measurements wheezers relate to symptoms lung function attacks. <h3>Methods</h3> Children aged 1–5 years with recurrent underwent finger-prick sampling for POC eosinophils. Forced oscillation technique (FOT) using 8Hz protocol and/or...
<h3>Introduction</h3> Improving efficiency in healthcare delivery while maintaining patient safety is central to providing high quality care, improved satisfaction and creates a culture of training for future paediatricians. Poor communication during handovers has been cited as being one the most dangerous interventions that clinicians put patients through. The SBAR handover tool recognised by WHO well National Health Service Institute Innovation Improvement simple standardised encourages...
<b>Introduction:</b> Exercise induced dyspnoea in children with asthma is usually attributed to exercise bronchoconstriction (EIB). Cardiopulmonary tests (CPET) help distinguish EIB from alternative, or co-existing causes of and thus guide treatment. <b>Aim:</b> To determine the prevalence other asthma. <b>Methods:</b> Retrospective analysis CPETs performed over 12-months (January 2019-January 2020) asthmatic dyspnoea. A maximal CPET (on a cycle ergometer treadmill) was defined as...
Abstract Allergic asthma generally starts during early life and is linked to substantial tissue remodelling lung dysfunction. Although angiogenesis a feature of the disrupted airway, impact allergic on pulmonary microcirculation unknown. Here, using quantitative imaging in precision-cut slices (PCLS), we report that exposure neonatal mice house dust mite (HDM) extract disrupts endothelial cell/pericyte interactions adventitial areas. Central blood vessel structure, loss pericyte coverage was...
Allergic asthma generally starts during early life and is linked to significant tissue remodelling lung dysfunction. Although angiogenesis a feature of the disrupted airway, impact allergic on pulmonary microcirculation unknown. Here, using quantitative imaging in precision-cut slices (PCLS), we report that exposure neonatal mice house dust mite (HDM) extract disrupts endothelial cell/pericyte interactions adventitial areas. Central blood vessel structure, loss pericyte coverage was driven...