A5005788932- Air Quality and Health Impacts
- Asthma and respiratory diseases
- Neonatal Respiratory Health Research
- Climate Change and Health Impacts
- Energy and Environment Impacts
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Noise Effects and Management
- Tracheal and airway disorders
- Respiratory and Cough-Related Research
- Child and Adolescent Health
- Air Quality Monitoring and Forecasting
- Pediatric health and respiratory diseases
- Airway Management and Intubation Techniques
- Cystic Fibrosis Research Advances
- Environmental Impact and Sustainability
- Indoor Air Quality and Microbial Exposure
- Trauma Management and Diagnosis
- Gastroesophageal reflux and treatments
- Viral gastroenteritis research and epidemiology
- Esophageal and GI Pathology
- Adolescent and Pediatric Healthcare
- Environmental Education and Sustainability
- Hybrid Renewable Energy Systems
- Occupational and environmental lung diseases
- Nosocomial Infections in ICU
Queen Mary University of London
2014-2025
Barts Health NHS Trust
2022-2023
Royal London Hospital
2022-2023
Genomics (United Kingdom)
2017-2023
University of Huddersfield
2022
Asthma UK
2016
Fairfield General Hospital
2010
Introduction Wheezing is common in preschool children and its clinical assessment often challenging for caretakers. This study aims to evaluate the impact of a novel digital wheeze detector (WheezeScan™) on disease control home care setting. Methods A multicentre randomised open-label controlled trial was conducted Berlin, Istanbul London. Participants aged 4–84 months with doctor's diagnosis recurrent wheezing past 12 were included. While group followed usual care, intervention received...
Objective: The asthma control test (ACT) is a validated tool for assessing in asthmatic children aged 12 years and older. Using the ACT, we sought to assess knowledge London secondary school children. Methods: Secondary schools London, UK, participated this study. Children with doctor-diagnosed were invited complete an online questionnaire that included ACT questions about asthma. Suboptimal was defined as score of ≤ 19 out maximum 25. Data are summarised median interquartile range (IQR),...
Exposure to particulate matter (PM) from burning of biomass for cooking is associated with adverse health effects. It unknown whether or not cleaner biomass-fuelled cookstoves reduce the amount PM inhaled by women compared traditional open fires. We sought assess airway macrophage black carbon (AMBC) - a marker dose carbonaceous and fossil fuel combustion lower in Malawian using cookstove those fires cooking. AMBC was assessed induced sputum samples image analysis personal exposure monoxide...
The purpose of this paper is the comparison environmental performance between a reusable face mask, made from British Wool, single-use conventional polypropylene (PP), and cotton using Life Cycle Assessment. analysis revealed that although one woollen mask has higher impact than PP its nature makes it more environmentally friendly in long term. Over period year, carbon footprint use approximately 46% lower whereas water depletion 28% lower. production cost with an active filtration layer...
Urban particulate matter (PM) enhances airway dendritic cell (DC) maturation in vitro. However, to date, there are no data on the association between exposure urban PM and DC vivo. We sought determine whether of school-age children (8 14 y) was associated with expression CD86, a marker conventional DCs (cDC). Healthy London school underwent spirometry sputum induction. Flow cytometry used identify CD86 CCR7 cDC subsets (CD1c+ cDC2 CD141+ cDC1). Tertiles mean annual ≤ 10 microns (PM10) at...
<b>Using an advice-based intervention in a cohort of children with asthma, designed to reduce personal pollution exposure, mean reduction black carbon exposure 34% was found, the primary happening within home environment</b>https://bit.ly/301Xemt
Hintergrund Giemen ist eine häufige Erkrankung bei Kindern im Säuglings- und Vorschulalter, deren Behandlung häuslichen Umfeld herausfordernd sein kann. Das elterliche Krankheitsmanagement kann durch digitale Gesundheitstechnologien unterstützt werden. Ziel dieser Studie es, die Auswirkungen eines innovativen, kommerziell erhältlichen, digitalen Detektors für giemende Atmung (WheezeScan, Omron Healthcare, Kyoto, Japan) auf das klinische Krankheitsbild zu untersuchen.
We therefore sought to identify the exposures associated with lung surface in long-term residents of São Paulo, Brazil.Lung carbon were analyzed 72 autopsy specimens by image analysis. Smoking history, measured PM10 nearest home, distance main road, and distance-weighted traffic density used as exposure variables. Data are summarized median (IQR), compared Mann Whitney Test, correlations done Spearman's correlation.There was no association between age or gender. There statistically...
Abstract Introduction Wheezing is an important indicator of exacerbated respiratory symptoms in early childhood and must be monitored to regulate pharmacological therapy. However, parents’ subjective perception wheezing their children not always precise. We investigated the objective identification children's by parents using a digital wheeze detector (WheezeScan TM , OMRON Healthcare Co. Ltd), its longitudinal usage patterns, relationship with SABA administration. Methods conducted...
Abstract Isolated remethylation defects are rare inherited diseases caused by a defective of homocysteine to methionine, preventing various essential methylation reactions occur. Patients present with systemic phenotype, which can especially affect the central and peripheral nervous systems leading epileptic encephalopathy, developmental delay neuropathy. Respiratory failure has been described in some cases, both neurological involvement. In published genetic diagnosis initiation appropriate...
<h3>Background</h3> London is one of the most heavily polluted cities in Europe. Tower Hamlets an area North East and 'air quality management area'. Over 40% its residents reside unacceptable air quality. The impact on children's health significant long-lasting exacerbated by fact that they also attend schools some parts city. In fact, has 6th worst rates admission for childhood asthma exacerbations Greater London. Despite this professionals have limited time or resources to meaningful...
<b>Background:</b> Although the mechanism underlying air pollution exposure's adverse effects on lung function is unclear, oxidative stress implicated in a range of health pollution. Urinary 8-Oxo-29-deoxyguanosine (8-oxo-dG) marker DNA oxidation and stress. We sought to assess associations' between exposure fossil fuel derived children living London (UK). <b>Methods:</b> After informed parental consent, healthy aged 8-14 were recruited from schools Greater London. Spot urine samples...
<b>Background:</b> We have seen the wealth of evidence regarding outdoor air pollution and health, in particular impact on children with asthma. However, home environment can be just as significant a source great stress to parents. This is particularly true those that live our most deprived neighbourhoods where families are reliant landlord council ensure they safe housing. In Tower Hamlets, mould overcrowding frequently concern for dealing wheeze sought explore extent this problem...
<h3>Background</h3> Sputum eosinophil counts are unstable in childhood asthma.<sup>1</sup> This makes sputum induction to quantify eosinophils an unsuitable test guide anti-inflammatory therapy.<sup>2</sup> While may be cleared following apoptosis, free granules, containing effector proteins, persist the airway lumen. We speculated that inflammatory mediators exhaled breath condensate, released by (such as cationic protein (ECP)) could aid risk-profiling children with asthma. therefore...
<b>Background:</b> Modelled exposure of children to particulate matter (PM) is widely used assess long term exposure, but whether this reflects personal remains unclear. We therefore sought determine attending London schools in the higher tertile modelled have black carbon (BC) assessed over a typical school day. <b>Methods:</b> Children aged 8-14 were recruited through their school. Participants divided tertiles based on PM<sub>10</sub> using Air Quality Toolkit (LAQT) previous 12 months....
<b>Background:</b> Exposure to black carbon particulate matter, predominately generated by diesel vehicles, is associated with a wide range of adverse effects on respiratory health. Since London one the most polluted cities for (BC) in Europe, ways that individuals may mitigate their own exposure are interest. One option use commercially available websites plan lower commuting routes. This study assessed feasibility this approach. <b>Methods:</b> A researcher carried personal BC monitor...