A5014027911- Vibrio bacteria research studies
- Viral gastroenteritis research and epidemiology
- Child Nutrition and Water Access
- Salmonella and Campylobacter epidemiology
- COVID-19 epidemiological studies
- Global Maternal and Child Health
- Vaccine Coverage and Hesitancy
- SARS-CoV-2 and COVID-19 Research
- Hepatitis Viruses Studies and Epidemiology
- Poverty, Education, and Child Welfare
- Microfinance and Financial Inclusion
- Escherichia coli research studies
- Intergenerational Family Dynamics and Caregiving
- Urban and Rural Development Challenges
- COVID-19 Clinical Research Studies
- Adolescent Sexual and Reproductive Health
- Reproductive Health and Contraception
- Antibiotic Resistance in Bacteria
- Healthcare Systems and Reforms
- Global Health and Epidemiology
- Liver Disease and Transplantation
- Fecal contamination and water quality
- Social and Economic Development in India
- Hepatitis B Virus Studies
- Clostridium difficile and Clostridium perfringens research
International Centre for Diarrhoeal Disease Research
2017-2025
Shahjalal University of Science and Technology
2008-2022
BackgroundTyphoid fever remains a major cause of morbidity and mortality in low-income middle-income countries. Vi-tetanus toxoid conjugate vaccine (Vi-TT) is recommended by WHO for implementation high-burden countries, but there little evidence about its ability to protect against clinical typhoid such settings.MethodsWe did participant-masked observer-masked cluster-randomised trial preceded safety pilot phase an urban endemic setting Dhaka, Bangladesh. 150 clusters, each with...
Vaccination constitutes an attractive control measure for hepatitis E virus (HEV), a major cause of maternal and perinatal mortality globally. Analysis pregnant participants in effectiveness trial the HEV vaccine HEV239 showed possible HEV239-associated fetal losses. We aimed to conduct detailed analysis this safety signal.
COVID-19 caused by SARS-CoV-2 ranges from asymptomatic to severe disease and can cause fatal devastating outcome in many cases. In this study, we have compared the clinical, biochemical immunological parameters across different spectrum of Bangladeshi patients.
Background Understanding the characteristics of humoral immune responses following COVID-19 vaccinations is crucial for refining vaccination strategies and predicting to emerging SARS-CoV-2 variants. Methods A longitudinal analysis spike receptor binding domain (RBD) specific IgG antibody responses, encompassing subclasses IgG1, IgG2, IgG3, IgG4 was performed. Participants received four mRNA vaccine doses (group 1; n=10) or two ChAdOx1 nCoV-19 booster 2; n=19) in Bangladesh over years....
Missing from the huge literature on women's attitudes and beliefs concerning specific contraceptive methods is any detailed quantitative documentation for all major in low- middle-income countries. The objectives are to provide such a women living Matlab (rural Bangladesh), Nairobi slums Homa Bay Kenya) compare opinions of current, past never users towards three most commonly used (oral contraceptives, injectables implants). In each site, 2424 2812 married aged 15–39 years were interviewed...
Abstract Background Shigella is an important cause of diarrhea in Bangladeshi children <5 years age, with incidence rate 4.6 per 100 person-years. However, the report was more than a decade old, and data on consequences are similarly outdated heterogeneously collected. Methods Facility-based disease surveillance planned to be carried out under Enterics for Global Health (EFGH) Surveillance Study consortium 2 aims optimize standardize laboratory techniques healthcare utilization...
Patients with cholera have been shown to be protected against subsequent for 3 years after their initial episode. We aimed assess protection at 10 of follow-up. In this retrospective cohort study, cohorts patients treated (index patients) and contemporaneously selected age-matched individuals without (controls), randomly from the population Matlab, Bangladesh, were assembled between 1990 2009 followed up years. Selection participants who had no history in 5 before selection proceeded secular...
Shigella spp are among the notable causes of global diarrheal disease and death, accounting for 13.2% deaths in 2016. Antimicrobial resistance complicates shigellosis management. Understanding local epidemiology is crucial developing effective preventive strategies, including vaccine use. We investigated antimicrobial resistance, risk factors (socioeconomic, behavioral, water, sanitation hygiene (WaSH), clinical characteristics diarrhea Mukuru informal settlement surrounding villages...
When delivered through vaccination Vi-polysaccharide antigen of Salmonella enterica serotype Typhi protects against typhoid by inducing IgG anti-Vi antibodies. We aimed to determine whether the presence antibodies following natural infection is associated with a lower incidence fever in endemic regions. analyzed data from cohort study conducted Dhaka, Bangladesh. Plasma were measured using standard enzyme-linked immunosorbent assay random serosurveys population that had not previously...
Introduction Millions of Euvichol-Plus doses have been deployed from the global oral cholera vaccine stockpile in over 20 cholera-affected countries. However, information on Euvichol-Plus’s effectiveness is limited. Using this a epidemic Dhaka, Bangladesh, provided opportunity to evaluate (VE) using test-negative design. Methods A two-dose regimen was administered individuals aged >1 year population ca. 900 000 two campaign rounds between June and August 2022, with prospective...
Smoke from biomass fuels used for cooking in traditional cookstoves contains a variety of health-damaging pollutants. Inhalation these pollutants by pregnant women has been linked to abnormal foetal development and adverse pregnancy outcomes, including low birthweight (LBW). There is dearth data on environmental interventions that have the potential reduce exposure fuel during improve birth outcomes. International Centre Diarrheal Disease Research, Bangladesh (icddr,b) therefore, designed...
BackgroundKilled whole-cell oral cholera vaccines (OCVs) are widely used for prevention of in developing countries. However, few studies have evaluated the protection conferred by internationally recommended OCVs durations beyond 2 years follow-up.MethodsIn this study, we followed up participants a cluster-randomised controlled trial after end original trial. Originally, had randomised 90 geographical clusters Dhaka slums Bangladesh equal numbers (1:1:1) to two-dose regimen OCV alone...
Abstract Background Typhoid fever contributes to approximately 135 000 deaths annually. Achievable improvements in household water, sanitation, and hygiene (WASH) combined with vaccination using typhoid conjugate vaccines (TCVs) may be an effective preventive strategy. However, little is known about how improved WASH interact lower the risk of typhoid. Methods A total 61 654 urban Bangladeshi children aged 9 months <16 years, residing 150 clusters a baseline population 205 760...
Oral cholera vaccine (OCV) and incremental improvements in household water, sanitation, hygiene (WASH) within cholera-endemic areas can reduce risk. However, we lack empiric evaluation of their combined impact.
Abstract Background Sustained investments in water, sanitation, and hygiene (WASH) have lagged resource-poor settings; incremental WASH improvements may, nonetheless, prevent diseases such as typhoid disease-endemic populations. Methods Using prospective data from a large cohort urban Kolkata, India, we evaluated whether baseline variables predicted risk training subpopulation (n = 28 470). We applied machine learning algorithm to the subset create composite, dichotomous (good, not good)...
In Sunamganj there are fewer than four skilled providers per 10,000 population and just 27% of births assisted by a attendant. We evaluate private community birth attendant (P-CSBA) model, developed through the GSK-CARE Frontline Health Worker Programme, designed to address this gap report on changes in service utilization health outcomes from baseline three years post-baseline.This analysis presents results pre-post cross sectional design. A survey (n = 1800) was conducted using multistage...
ObjectiveThe objective was to assess the provision of combination mifepristone–misoprostol for menstrual regulation (MR) in randomly selected urban pharmacies Bangladesh.Study designWe conducted a cross-sectional survey among 553 pharmacy workers followed by 548 mystery client visits same 3 municipal districts during July 2014–December 2015.ResultsThe found that 99% visited had knowledge MR procedures but only two-thirds (67%) could state legal time limit correctly; they mentioned...
Enterotoxigenic Escherichia coli (ETEC) and Vibrio cholerae O1 are most common bacterial causes of diarrheal diseases in Bangladesh. This analysis projected distribution ETEC V. among patients icddr,b, Dhaka hospital two peaks 2022.Under the 2% systematic surveillance system, stool samples collected from icddr,b were cultured diagnostic testing was done for O1. Comparison positive cases between first peak (March-April) second (October-November) 2022.A total 2,937 specimens tested which 12%...
BackgroundCholera remains a major public health threat in low- and middle-income countries. The World Health Organization (WHO) has recently launched global initiative to end preventable cholera by 2030. Key the success of this will be elimination transmission ‘hotspots’ with regularly recurrent disease; can achieved via improved surveillance define hotspot populations, through use oral vaccines, implementation water, sanitation, hygiene (WASH).MethodsThis study was performed analyze trend...
Most of the earlier studies examined impact microfinance on poverty reduction. Few emphasized broader policy framework and implementation process—the actors factors associated with process, which are critical to make an impact. This study is attempt explore whether public service reaches poorest through qualitative case evidence. Some quantitative argued that non-profit-oriented Microfinance Institutions (MFIs) have greater outreach than profit-oriented MFIs. argues even non-profit MFIs...
Modest improvements in household water, sanitation, and hygiene (WASH) typhoid vaccination can reduce risk endemic settings. However, empiric evaluation of their combined impact is lacking. A total 62,756 persons residing 80 clusters a Kolkata slum were allocated randomly 1:1 to either the Vi polysaccharide (ViPS) vaccine or hepatitis (Hep A) vaccine. Surveillance was conducted for 2 years before after vaccination. We classified households as having "better" "not better" WASH, calculated...
The objective of this study was to assess the prevalence, antimicrobial resistance patterns, and risk factors linked
Participatory research was conducted with adolescent girls and women in three isolated rural communities of Bangladesh to assess their perspectives the role social gender norms on construction knowledge regarding menstruation, pregnancy abortion. Norms privacy silence, local beliefs a culture shame held that human body is 'natural' does not require formal sexual reproductive health care. Instead, participants sought out traditional healers used herbal plants as natural remedies. Participants...