A5005802554- Adipose Tissue and Metabolism
- Liver Disease Diagnosis and Treatment
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Disease and Adiposity
- Adipokines, Inflammation, and Metabolic Diseases
- Diabetes and associated disorders
- Pancreatic function and diabetes
- Diabetes Management and Research
- Nutrition and Health in Aging
- Regulation of Appetite and Obesity
- Diet and metabolism studies
- Body Composition Measurement Techniques
- Lipid metabolism and disorders
- Muscle metabolism and nutrition
- Obesity, Physical Activity, Diet
- Diabetes Management and Education
- Frailty in Older Adults
- Iron Metabolism and Disorders
- Clusterin in disease pathology
- Diet, Metabolism, and Disease
- Hemoglobinopathies and Related Disorders
- Exercise and Physiological Responses
- Complement system in diseases
- Alcohol Consumption and Health Effects
- Sports Performance and Training
King's College London
2017-2024
University of Roehampton
2023
University of Cape Town
2020
University of Washington
2020
Umeå University
2020
The London College
2020
California University of Pennsylvania
2020
We assessed differences in mitochondrial function gluteal (gSAT) and abdominal subcutaneous adipose tissue (aSAT) at baseline response to 12-weeks of exercise training; examined depot-specific associations with body fat distribution insulin sensitivity (SI). Obese, black South African women (n = 45) were randomized into 23) or control 22) groups. Exercise group completed aerobic resistance training 20), while the 15) continued usual behaviours. Mitochondrial (high-resolution respirometry...
Introduction It is increasingly recognized that type 2 diabetes (T2D) a heterogenous disease with ethnic variations. Differences in insulin secretion, resistance and ectopic fat are thought to contribute these Therefore, we aimed compare postprandial secretion the relationships between sensitivity pancreatic men of black West African (BA) white European (WE) ancestry. Research design methods A cross-sectional, observational study which 23 WE BA normal glucose tolerance, matched for body mass...
Type 2 diabetes is more prevalent in black African than white European populations although, paradoxically, individuals present with lower levels of visceral fat, which has a known association insulin resistance. Insulin resistance occurs at tissue-specific level; however, no study simultaneously compared whole body, skeletal muscle, hepatic and adipose tissue sensitivity between men. We hypothesised that, those early type diabetes, (West) men (BAM) have greater sensitivity, (WEM), because...
To examine the hypothesis that there would be ethnic differences in relationship between ectopic fat and tissue-specific insulin resistance (IR) across a spectrum of glucose tolerance Black African (BA) White European (WE) men.
We investigated the effects of a 12-week exercise intervention on insulin sensitivity (SI) and hyperinsulinemia associated changes in regional ectopic fat.Healthy, black South African women with obesity (mean age 23 ± 3.5 years) isiXhosa ancestry were randomised into aerobic resistance training group (n = 23) no (control, n 22). Pre post-intervention testing included assessment SI, response to glucose (AIRg), secretion rate (ISR), hepatic extraction (FEL) disposition index (DI) (AIRg × SI)...
Intrahepatic lipid (IHL) is linked with reduced hepatic insulin sensitivity and clearance. Despite their high risk for type 2 diabetes (T2D), there have been limited investigations of these relationships in black populations. We investigated 18 white European (WE) West African (BWA) men T2D <5 years. They underwent magnetic resonance imaging to quantify IHL, a hyperinsulinemic euglycaemic clamp [6,6 H2 ] glucose infusion assess hyperglycaemic BWA had lower IHL than WE (3.7 [5.3] vs 6.6...
Abstract Aim To investigate relationships between insulin clearance, secretion, hepatic fat accumulation and sensitivity in black African (BA) white European (WE) men. Methods Twenty‐three BA twenty‐three WE men with normal glucose tolerance, matched for age body mass index, underwent a hyperglycaemic clamp to measure secretion hyperinsulinaemic‐euglycaemic stable isotope infusion whole‐body hepatic‐specific sensitivity, magnetic resonance imaging quantify intrahepatic lipid ( IHL ). Results...
Intrapancreatic lipid (IPL) has been linked to β-cell dysfunction. Black populations disproportionately develop type 2 diabetes (T2D) and show distinctions in function compared with white populations. We quantified IPL European (WE) black West African (BWA) men early T2D investigated the relationships between insulin secretory (ISF). performed a cross-sectional assessment of 18 WE 19 BWA middle-age as part South London Diabetes Ethnicity Phenotyping study. The participants underwent Dixon...
In men of black west African (BAM) and white European (WEM) ethnicity, we aimed to (1) compare adipose tissue, peripheral hepatic insulin sensitivity (2) investigate associations between ectopic fat by ethnicity.In overweight BAM (n = 21) WEM 23) with normal glucose tolerance, performed a two-step hyperinsulinaemic-euglycaemic clamp infusion [6,6 2H2]-glucose [2H5]-glycerol measure whole body, peripheral, tissue (lipolysis). Visceral (VAT), intrahepatic lipids (IHL) intramyocellular (IMCL)...
In this study, we aimed to assess ethnic differences in visceral (VAT), deep subcutaneous (dSAT), and superficial (sSAT) adipose tissue their relationships with inflammatory markers between white European (WE) black West African (BWA) men normal glucose tolerance (NGT) type 2 diabetes (T2D). Forty-two WE (23 NGT/19 T2D) 43 BWA NGT/20 underwent assessment of plasma using immunoassays alongside Dixon magnetic resonance imaging quantify L4-5 VAT, dSAT sSAT. Despite no sSAT dSAT, exhibited lower...
Inflammation plays a fundamental role in the development of several metabolic diseases, including obesity and type 2 diabetes (T2D); complement system has been implicated their development. People Black African (BA) ethnicity are disproportionately affected by T2D other diseases but impact on not explored. We investigated ethnic differences biomarkers activation status between men BA White European (WE) explored association with parameters health. measured panel 15 components, regulators,...
Abstract Aim People of Black African ancestry, who are known to be at disproportionately high risk type 2 diabetes (T2D), typically exhibit lower hepatic insulin clearance compared with White Europeans. However, the mechanisms underlying this metabolic characteristic poorly understood. We explored whether low in (BA) men could explained by resistance, subclinical inflammation or adiponectin concentrations. Methods BA and European (WE) men, categorised as either normal glucose tolerant (NGT)...
We aimed to assess ethnic differences in inflammatory markers and their relationships with insulin sensitivity regional adiposity between white European black African men.A total of 53 men underwent assessment alongside Dixon-magnetic resonance imaging quantify subcutaneous visceral adipose tissue intrahepatic lipid. A hyperinsulinaemic-euglycaemic clamp was used measure whole-body sensitivity. To relationships, the statistical significance an interaction term adipokines group tested...
The role of ectopic fat, insulin secretion and clearance in the preservation ofβ-cell function black African women with obesity who typically present hyperinsulinaemia is not clear. We aim to examine associations between disposition index (DI, an estimate β-cell function), fat deposition. This a cross-sectional study 43 South (age 20–35 years) (BMI 30–40 kg/m 2 ) without type diabetes that measured following: DI, sensitivity (S I ), acute response (AIRg), rate (ISR), hepatic extraction...
An abstract is not available for this content. As you have access to content, full HTML content provided on page. A PDF of also in through the ‘Save PDF’ action button.
An abstract is not available for this content. As you have access to content, full HTML content provided on page. A PDF of also in through the ‘Save PDF’ action button.
An abstract is not available for this content. As you have access to content, full HTML content provided on page. A PDF of also in through the ‘Save PDF’ action button.
Abstract Background Sarcopenia is an age‐related loss of skeletal muscle mass (SMM) and function, associated with falls, frailty, functional decline. It more prevalent often accelerated in people Type 2 diabetes (T2D), especially when co‐existing obesity (sarcopenic obesity). Accurate whole‐body SMM measurement, feasible using dual‐energy X‐ray absorptiometry (DXA) or magnetic resonance imaging (MRI), has utility both clinical practice epidemiological mechanistic research, considering the...
An abstract is not available for this content. As you have access to content, full HTML content provided on page. A PDF of also in through the ‘Save PDF’ action button.
An abstract is not available for this content. As you have access to content, full HTML content provided on page. A PDF of also in through the ‘Save PDF’ action button.