A5012806061- Diabetic Foot Ulcer Assessment and Management
- Tracheal and airway disorders
- Wound Healing and Treatments
- BRCA gene mutations in cancer
- Central Venous Catheters and Hemodialysis
- Pressure Ulcer Prevention and Management
- Prenatal Screening and Diagnostics
- Clinical Nutrition and Gastroenterology
- Genomics and Rare Diseases
- Ethics in Clinical Research
- Pharmaceutical studies and practices
- Dialysis and Renal Disease Management
- Diagnosis and Treatment of Venous Diseases
- Congenital Diaphragmatic Hernia Studies
- Delphi Technique in Research
- Cystic Fibrosis Research Advances
- Innovations in Medical Education
- LGBTQ Health, Identity, and Policy
- Treatment of Major Depression
- Organ Donation and Transplantation
- Congenital Anomalies and Fetal Surgery
- Complement system in diseases
- Streptococcal Infections and Treatments
- Gender Roles and Identity Studies
- Shoulder Injury and Treatment
Murdoch Children's Research Institute
2019-2025
Mount Sinai Hospital
2024-2025
SerenaGroup Research Institute
2023-2024
Neuroscience Research Australia
2024
UNSW Sydney
2024
Royal Children's Hospital
2024
Children's Hospital at Westmead
2024
Sydney Children's Hospital
2024
Victorian Clinical Genetics Services
2024
The University of Sydney
2024
BackgroundGenomic sequencing technology allows for identification of reproductive couples with an increased chance, as compared that in the general population, having a child autosomal recessive or X-linked genetic condition.MethodsWe investigated feasibility, acceptability, and outcomes nationwide, couple-based carrier screening program Australia part Mackenzie's Mission project. Health care providers offered to persons before pregnancy early pregnancy. The results obtained from testing at...
Objective Even as genomic medicine is implemented globally, there remains a lack of rigorous, national assessments physicians’ current practice and continuing genomics education needs. The aim this study was to address gap. Design A cross-sectional survey, informed by qualitative data behaviour change theory, assess the landscape Australian practice, perceptions proximity individual preparedness, preferred models education. survey advertised nationally through 10 medical colleges, 24...
Reproductive genetic carrier screening (RGCS) provides people with information about their chance of having children autosomal recessive or X-linked conditions, enabling informed reproductive decision-making. RGCS is recommended to be offered all couples during preconception in early pregnancy. However, cost and a lack awareness may prevent access. To address this, the Australian Government funded Mackenzie’s Mission—the Genetic Carrier Screening Project. Mission aims assess acceptability...
Abstract Genomic medicine is being implemented on a global scale, requiring genomic-competent health workforce. To inform education as part of implementation strategies to optimize adoption genomics by non-genetics physicians, we investigated current practices, perceptions and preferences relating genomic testing education. Australian physicians completed an online survey; conducted univariate multivariate analyses determinants confidence engagement with medicine. Confident or engaged...
Despite some early implementation of genomic medicine globally, there is a lack rigorous, large-scale assessments medical specialists' current practice and continuing education needs. As first step to addressing this gap, we describe the development robust, expert-reviewed, survey using mixed-methods sequential study design. We conducted semi-structured qualitative interviews with 32 providers 86 non-genetic specialists about need for education. Key concepts were identified used as an...
(Abstracted from N Engl J Med 2024;391:1877–1889) Couple-based genetic carrier screening analyzes parental samples before or early in pregnancy to assess the risk of autosomal and X-linked recessive diseases their children. Previously, carriers were often unidentified until after having an affected child but advances sequencing now allow simultaneous across thousands genes, giving prospective parents greater insight into risk.
Abstract Patients with Down syndrome (DS) have significant specialized healthcare needs. Our objective was to understand what families of patients DS perceive be the most pressing gaps in health care, barriers attendance at a specialty clinic, and they thought clinic for people ought include as part clinical package. A qualitative survey distributed nationally through online platform SurveyMonkey. We divided respondents into two groups: those who attended ( n = 141) did not 100). Data were...
Objective: Excessive numbers of bacteria in hard-to-heal wounds impede wound healing. Numerous topical antiseptics have demonstrated effectiveness benchtop studies; however, few clinical studies efficacy the target population: patients with wounds. This study addressed a novel antibiofilm cleanser and gel reducing bacterial load improving outcomes. Method: Hard-to-heal were photographed, measured evaluated for using fluorescence imaging weekly four weeks. The ulcers randomised to be cleaned...
Background: Each year, millions of Americans develop truncal pressure ulcers (PUs) which can persist for months, years, or until the end life. Despite negative impact on quality life and escalating costs associated with PUs, there is sparse evidence supporting validated efficacious treatment options. As a result, based opinion extrapolation from other wound etiologies. The ideal reconstructive plan maximizes patient’s nutritional status, incorporates basic tenets bed preparation...
Randomised controlled clinical trials remain the gold standard in assessing efficacy of a medical drug, device or intervention. Standardisation trial design reduces bias, ensures validity data, and allows for generalisation results to larger real-world population which has disease. Critics diabetic foot ulcer (DFU) point inconsistency endpoints between studies, lack translation DFU at large, failure include target advanced therapies, poorly defined care (SoC). These issues conduct were...
Early indicators of healing provide valuable information on the potential benefit treatment. In patients with hard-to-heal (chronic) diabetic foot ulcers (DFUs), timely intervention is critical. Ulcers that fail to show measurable progress within four weeks treatment are considered recalcitrant. These increase risk soft tissue infection, osteomyelitis and lower extremity amputation. A prognostic indicator or surrogate marker allows for rapid evaluation efficacy safety. An inverse correlation...
Background: Paramedics are an essential component of the healthcare system, providing unscheduled out-of-hospital care in a manner that should be unbiased towards all. Yet some members LGBTQIA+ (lesbian, gay, bisexual, transgender, queer/questioning, intersex and asexual) community still experience stigma when accessing healthcare, including paramedicine, which impacts health outcomes. Aims: This study aimed to ascertain prevalence bias among paramedicine students toward community. Methods:...
Introduction: Currently the best outcome for chronic intestinal failure (IF) is achieved by discharging children home after parent/carer(s) have undergone a formal training programme to connect and disconnect PN infusions from child’s central venous catheter (CVC). Catheter related bloodstream infections (CRBSI) are most common potentially life-threatening complication. The aim of this study was prospectively compare incidence CRBSI in short bowel syndrome (SBS) with IF other aetiologies at...
Chronic wound management is a global challenge. Millions of patients suffer from nonhealing ulcers and health systems are overwhelmed by the growing demand for treatment. Despite prevalence chronic wounds, emergence centers specialized physicians recent phenomenon. Likewise, clinical research in healing its infancy. To date, many products care have little or no evidence. The field needs standardized trial design, endpoints recognized clinicians payers, improved overall Wound impeded presence...