A5105771452- Microplastics and Plastic Pollution
- Aquaculture disease management and microbiota
- Nanoparticles: synthesis and applications
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cancer-related gene regulation
- Gut microbiota and health
- Peptidase Inhibition and Analysis
- Histone Deacetylase Inhibitors Research
- Invertebrate Immune Response Mechanisms
- Aquaculture Nutrition and Growth
- Vibrio bacteria research studies
- Viral Infectious Diseases and Gene Expression in Insects
- Pharmacogenetics and Drug Metabolism
- Drug Transport and Resistance Mechanisms
- Ferroptosis and cancer prognosis
- Adipose Tissue and Metabolism
- Air Quality and Health Impacts
- Mosquito-borne diseases and control
- Atmospheric chemistry and aerosols
- Head and Neck Cancer Studies
- Marine Biology and Environmental Chemistry
- FOXO transcription factor regulation
Shandong First Medical University
2019-2025
University of Science and Technology of China
2020-2025
Universiti Sains Malaysia
2021-2024
Xinxiang Medical University
2023-2024
Henan Normal University
2024
Shandong Freshwater Fisheries Research Institute
2022-2023
Institute of Hydrobiology
2023
ZheJiang Academy of Agricultural Sciences
2023
Academy of Medical Sciences
2023
Wenzhou Medical University
2021-2022
The application of solid electrolyte is expected to realize the commercialization high energy density lithium metal batteries (LMBs). While interfacial contact between inorganic and electrodes has become a stumbling block for achieving stable cycling in LMBs. In this work, Li-containing polyethylene oxide (LPEO) was introduced LAGP as buffer layer regulate compatibility reduce impedance, inhibiting side reactions. Moreover, ether-oxygen bond on LPEO chain can coordinate with Li+ guide...
Abstract Recent years have witnessed a growing research interest in traditional Chinese medicine as neuroprotective nutrient the management of diabetic cognitive dysfunction. However, underlying molecular mechanisms sinomenine mediating ferroptosis hippocampal neurons been poorly understood. This study sought to decipher potential effect and mechanism dysfunction following type 2 diabetes mellitus (T2DM). Multi‐omics analysis was conducted identify microbiota‐gut‐brain axis T2DM patient...
The long non-coding RNA, maternally expressed gene 3 (MEG3), are involved in myocardial fibrosis and compensatory hypertrophy, but its role on cardiomyocyte apoptosis autophagy heart failure (HF) remains unclear. aim of this study was to investigate the effect MEG3 underlying mechanism. A mouse model HF established by subcutaneous injection isoproterenol (ISO) for 14 days, an vitro oxidative stress injury replicated with H2O2 6 h. SiRNA-MEG3 administered mice cardiomyocytes knock down...
Transformed from p-phenylenediamines (PPDs) antioxidant, PPD-derived quinones (PPD-Qs) have recently been recognized as emerging contaminants due to their potential negative impacts on the environment and human health. While there measurements of airborne PPD-Qs, size distribution PPD-Qs impact particle PPD transformation chemistry remain largely unknown. Here, through atmospheric particles in three megacities China (Beijing, Xi'an, Hefei), we find that are widely distributed these cities....
Silicosis is a prevalent occupational disease marked by progressive pulmonary fibrosis. Despite its significant health burden, the pathogenesis of silicosis remains unclear, and no specific therapeutic drugs are available. In this study, we developed novel intervention strategy targeting gut microbiota investigated underlying mechanisms. Using 16S rRNA gene sequencing, observed dysbiosis in rats at different times (1-8 weeks), notably characterized altered relative abundance Ruminococcus...
Hepatocellular carcinoma is an aggressive neoplasm and one of the most common human cancers. Recently, long non-coding RNAs have been demonstrated to participate in pathogenesis many diseases including progression several In this study, we found that RNA colon cancer–associated transcript 1 was upregulated hepatocellular tissues (p < 0.05), high expression level positively associated with tumor volume 0.05) American Joint Committee on Cancer stage patients. Luciferase reporter assays...
Endothelial dysfunction is implicated in the thrombotic events reported patients with coronavirus disease (COVID-19), but underlying molecular mechanisms are unknown. Circulating levels of coagulation cascade activator PAI-1 substantially higher COVID-19 severe respiratory than bacterial sepsis and acute distress syndrome. Indeed, elevation recognized as an early marker endothelial dysfunction. Here, we report that rSARS-CoV-2-S1 (recombinant syndrome 2 [SARS-CoV-2] viral envelope spike)...
Chlorpyrifos (CPF) is an organophosphate insecticide commonly used to treat fruit and vegetable crops. CPF can cause severe adverse effects on body organs including the liver central nervous system. This study investigated CPF-induced inflammation in mice explored role of intestinal flora changes inflammation. Adult C57BL/6 male were exposed a 0.01-, 0.1-, 1- 10-mg/kg bodyweight for 12 weeks. The experimental group given solution dissolved corn oil vehicle by gavage, was administered...
We previously reported that histone deacetylase 6 (HDAC6) has an important role in endothelial cell (EC) function vitro . However, whether HDAC6 plays a atherogenesis vivo and the mechanism(s) control activity/expression response to atherogenic stimuli are unclear. The goals of this study were determine inhibitor tubacin attenuates elucidate specific molecular regulate expression/activity. evaluated administration attenuated or reversed dysfunction atherosclerosis induced mice by single...
We aimed to investigate the effects of quercetin and taxifolin on gut health in Chinese sucker (Myxocyprinus asiaticus). Short-term exposure (96 h) was conducted by exposing 2.5 mg/L (Q2.5), 5 (Q5), 10 (Q10), (T2.5), (T5), (T10), their combination (quercetin taxifolin: mg/L+5 mg/L, QT). Then, we analyzed intestinal microorganisms, fat composition, digestive enzyme activities, antioxidant inflammatory-related gene expression. Both had an inhibitory effect flora, higher concentration, better...
Oilseed flax (
OBJECTIVE: The transcription factor FOXF2 is reported to be down-regulated in HCC. Its deficiency correlated with shorter disease-free survival and overall of HCC patients; however, the mechanism remains elucidated. MATERIALS AND METHODS: In this study, we performed qRT-PCR stern blotting confirm tissue cell lines. Then line Huh7 transduced shRNA was adopted a series vitro vivo assays evaluate phenotype change, migration, invasion, proliferation, colonization circulating formation metastatic...
// Chunqing Dou 1 , Liyuan Sun Xin Jin Mingming Han Bao Zhang Xian Jiang Jinyong Lv and Tao Li Department of Hepatobiliary Surgery, The First Affiliated Hospital Chinese PLA General Hospital, Beijing, China Correspondence to: Dou, email: chunqingdou134@126.com Keywords: hepatocellular carcinoma, CARLo-5, EZH2, miR-200b, epithelial-mesenchymal transition Received: March 10, 2017 Accepted: June 19, Published: July 26, 2017 ABSTRACT Long non-coding RNAs (lncRNAs)...
Background/aims We recently described a novel regulatory role for histone deacetylase 2 (HDAC2) in protecting endothelial cells from oxidized low-density lipoprotein (OxLDL)-induced injury. In this study, we examined the effects of endothelial-specific HDAC2 overexpression on endothelial-dependent vasorelaxation and atherogenesis vivo. Methods Endothelial-specific HDAC2-overexpressing transgenic mice (HDAC2-Tg) were generated under control Tie2 promoter. An atherosclerosis model was produced...
Quercetin is a flavanol beneficial in reducing fat, promoting muscle growth, and Anti-oxidation. To study its effects freshwater fish, the full-length cDNA of follistatin (FST) myostatin (MSTN) genes dark sleeper Odontobutis potamophila were cloned for first time. Juvenile individual O. was exposed to quercetin at one four concentrations (0, 2.5, 5, 10 mg/L) 21 days. The expression level MSTN which inhibits growth solution lower than unexposed control group. that promote are TGF-β...