A5101398306- Immunotherapy and Immune Responses
- MRI in cancer diagnosis
- RNA Interference and Gene Delivery
- Radiomics and Machine Learning in Medical Imaging
- Renal cell carcinoma treatment
- Renal Diseases and Glomerulopathies
- Nanoplatforms for cancer theranostics
- Cytokine Signaling Pathways and Interactions
- Energy, Environment, Economic Growth
- Nanoparticle-Based Drug Delivery
- Chronic Kidney Disease and Diabetes
- Angiogenesis and VEGF in Cancer
- Environmental Impact and Sustainability
- Ultrasound and Hyperthermia Applications
- Chemokine receptors and signaling
- Advanced MRI Techniques and Applications
- Lung Cancer Diagnosis and Treatment
- Hepatitis B Virus Studies
- Immune Response and Inflammation
- Cancer, Hypoxia, and Metabolism
- Cardiovascular Function and Risk Factors
- Advanced Neuroimaging Techniques and Applications
- Mesenchymal stem cell research
- Diabetes Treatment and Management
- Silicone and Siloxane Chemistry
Zhejiang University
2021-2025
First Affiliated Hospital Zhejiang University
2024-2025
Dalian University
2022-2024
Dalian University of Technology
2022-2024
Zhengzhou University
2023
Guangzhou First People's Hospital
2014-2023
Guangzhou Medical University
2014-2023
South China University of Technology
2023
InferVision (China)
2023
Sir Run Run Shaw Hospital
2021-2022
Stimuli-responsive nano-immunochemotherapy modulates the tumor microenvironment to enhance antitumor immunity.
Virus-like particles (VLPs) are self-assembled viral proteins that represent a superior form of antigens in vaccine formulations. To enhance immunogenicity, adjuvants, especially the aluminum salts (Alum), essentially formulated VLP vaccines. However, Alum only induce biased humoral immune responses limits further applications VLP-based stimulate more balanced immunity, we, herein, develop one-step strategy using VLPs as biotemplates to synthesize raspberry-like silica-adjuvanted VLP@Silica...
Tumor invasiveness plays a key role in determining surgical strategy and patient prognosis clinical practice. The study aimed to explore artificial-intelligence-based computed tomography (CT) histogram indicators significantly related the invasion status of lung adenocarcinoma appearing as part-solid nodules (PSNs), construct radiomics models for prediction tumor invasiveness. We identified surgically resected adenocarcinomas manifesting PSNs Peking University People's Hospital from January...
Rationale: The synergism of new modalities alongside chemodynamic therapy into common chemotherapy has shown promising potential in clinical applications. This paper reports a tumor microenvironment-responsive nanosystem for chemodynamic/chemical synergistic and magnetic resonance imaging (MRI). Methods: biodegradable is synthesized using surface-modified chain transfer agent surface-initiated living radical polymerization the chemotherapeutic drug. Results: In this nanosystem, named...
In order to achieve China’s carbon peaking and neutrality (double carbon) targets advance ecological conservation high-quality development in the Yellow River Basin, it is essential that China reduces its energy intensity increases efficiency. This research developed an evaluation index system for efficiency green Basin based on panel data collected from 64 of prefecture-level cities covering period 2011 2020. Each city’s level was calculated, analyzed together with characteristics spatial...
A novel flame retardant (FR) containing phosphorus and calixarene structures was synthesized, the FR combined with ammonium polyphosphate (APP) then incorporated into polystyrene (PS). The retardancy thermal stability of composites were investigated. limiting oxygen index can reach 21.0% when mass ratio FR/APP 3:2. Char residues at 650°C in an air atmosphere increased from 2.2% to 21.5% notably PS matrix, indicating improvement thermo‐oxidation resistance. Compared virgin FR/PS composites,...
This study aims to evaluate the clinical diagnostic value of contrast-enhanced ultrasound combined with microflow imaging (CEUS-MFI) in differential diagnosis benign and malignant renal tumors. All patients underwent CEUS, MFI, color doppler flow (CDFI), CEUS-MFI. The efficacies these different modalities diagnosing tumors were evaluated by Kappa consistency test receiver operating characteristic (ROC) curve, pathological findings serving as gold standard. CDFI, MFI CEUS-MFI all demonstrated...
Aluminum salts still remain as the most popular adjuvants in marketed human prophylactic vaccines due to their capability trigger humoral immune responses with a good safety record. However, insufficient induction of cellular limits further applications. In this study, we prepare library silicon (Si)- or calcium (Ca)-doped aluminum oxyhydroxide (AlOOH) nanoadjuvants. They exhibit well-controlled physicochemical properties, and dopants are homogeneously distributed By using Hepatitis B...
Objective To explore independent risk factors for incomplete radiofrequency ablation (iRFA) of colorectal cancer liver metastases (CRLM) and evaluate adverse outcomes following iRFA.Materials Methods Magnetic resonance imaging data CRLM patients who received percutaneous RFA were randomized into training (70%) validation set 1 (30%) sets. An 2 was derived from computed tomography scans. Uni- multivariate analyses identified iRFA. Area under the curve (AUC) values used to predictive model...
ObjectiveTo investigate the ameliorative effect of Semaglutide-loaded PEG-nanoliposomes (Sem-PEG-lips) combined with ultrasound-targeted microbubble destruction (UTMD) on streptozotocin (STZ)-induced diabetic cardiomyopathy (DCM) in rodents and its potential mechanisms.MethodsSem-PEG-lips were prepared by reverse phase evaporation method. Fifty STZ-induced rats randomly divided into DCM model group, Sem or Sem-PEG-lips alone treatment UTMD + group (n = 10), respectively, used healthy as...
To develop an iron-based solid lipid nanoparticle (SLN) absorbable by the intestinal wall and assess differential diagnostic value of lesions in magnetic resonance imaging (MRI).
The distribution and morphology of mass microvessels could affect the diagnostic accuracy breast cancer (BC). aim our study was to compare value contrast-enhanced ultrasound micro-flow imaging (CEUS-MFI), (CEUS), color Doppler flow (CDFI) in assessment microvasculature.
This study aims to evaluate the clinical diagnostic value of contrast-enhanced ultrasound combined with microflow imaging (CEUS-MFI) in differential diagnosis benign and malignant renal tumors. All patients underwent CEUS, MFI, color doppler flow (CDFI), CEUS-MFI. The efficacies these different modalities diagnosing tumors were evaluated by Kappa consistency test receiver operating characteristic (ROC) curve, pathological findings serving as gold standard. CDFI, MFI CEUS-MFI all demonstrated...
Bone marrow-derived mesenchymal stem cells (BMSCs) are increasingly being used in bone marrow transplantation (BMT) to enable homing of the allogeneic hematopoietic and suppress acute graft versus host disease (aGVHD). The aim this study was optimize labelling BMSCs with superparamagnetic iron oxide particles (SPIOs), evaluate impact SPIOs on biological characteristics, gene expression profile chemotaxis function BMSCs. viability proliferation rates SPIO-labeled were analyzed by trypan blue...
Objective To observe the expression and distribution of α-actin-4 mRNA through puromycin aminonueleoside(PAN) injury podocyte, discuss relation between podocyte damage. Methods Podocytes were cultured in vitro, 2 groups set up: control group PAN stimulation group.The was with concentration 100 mL/L FBS RPMI 1640 nutrient solution culture, while cultiva-ted to PAN(50 mg/L) treatment, cell morphology, extraction total RNA observed 8 h, 24 h 48 h. The morphology pictures taken...