A5003772838- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- Antimicrobial Peptides and Activities
- Graphene and Nanomaterials Applications
- Immune Response and Inflammation
- Viral Infections and Vectors
- Gout, Hyperuricemia, Uric Acid
- Neonatal Respiratory Health Research
- Advanced biosensing and bioanalysis techniques
- Bacteriophages and microbial interactions
- Infant Nutrition and Health
- Graphene research and applications
- Nanoparticles: synthesis and applications
- Carbon and Quantum Dots Applications
- Inflammasome and immune disorders
- Nanoparticle-Based Drug Delivery
- Hepatitis B Virus Studies
Dalian University
2017-2022
Dalian University of Technology
2017-2022
Virus-like particles (VLPs) are self-assembled viral proteins that represent a superior form of antigens in vaccine formulations. To enhance immunogenicity, adjuvants, especially the aluminum salts (Alum), essentially formulated VLP vaccines. However, Alum only induce biased humoral immune responses limits further applications VLP-based stimulate more balanced immunity, we, herein, develop one-step strategy using VLPs as biotemplates to synthesize raspberry-like silica-adjuvanted VLP@Silica...
Nano-graphene oxide (NGO) has been proposed as a novel drug carrier. However, the poor biocompatibility and physiological stability well lack of cancer targeting capability have limited its further applications in therapy. To solve this problem, we developed nanohybrid NGO/DOX@SPC-FA by first allowing soy phosphatidylcholine membrane (SPC) to encapsulate DOX-loaded NGO (NGO/DOX) then modifying SPC with PEGylated lipid-FA conjugate achieve display FA on surface. The (mimicking cell membrane)...
Hydroxyapatite (HAP) has been formulated as adjuvants in vaccines for human use. However, the optimal properties required HAP nanoparticles to elicit adjuvanticity and underlying immunopotentiation mechanisms have not fully elucidated. Herein, a library of nanorods nanospheres was synthesized explore effect particle shape aspect ratio on immune responses vitro vivo. It demonstrated that long induced higher degree cell membrane depolarization subsequent uptake, internalized particles elicited...