Ocean forecasting is critical for various applications and essential understanding air-sea interactions, which contribute to mitigating the impacts of extreme events. State-of-the-art ocean numerical systems can offer lead times up 10 days with a spatial resolution kilometers, although they are computationally expensive. While data-driven models have demonstrated considerable potential speed, often primarily focus on variations while neglecting temporal dynamics. This paper presents...

Lung adenocarcinoma (LUAD) is the most common subtype of nonsmall cell lung cancer, and 5-year survival rate only 15% in recent years. This study aimed to explore FAM83A expression its potential functions LUAD. Data LUAD were downloaded from The Cancer Genome Atlas database. Expression level was compared between samples adjacent normal samples. association clinic-pathological parameters analyzed, as well copy number variation methylation status. Kaplan-Meier curve used visualize relationship...

Abstract Background Long non-coding RNAs (lncRNAs) are pervasively transcribed in genome and emerging as a new player tumorigenesis due to their functions transcriptional, posttranscriptional epigenetic mechanisms of gene regulation. As the most frequent malignancy foremost source cancer mortality, lung is heterogeneous disorder. The common type Non-small cell (NSCLC), occupying 85% total cases, main subtypes NSCLC include adenocarcinoma (LAD), large carcinoma (LCC), squamous (LSCC)....

Recently, LOC285194 has shown a potential tumor-suppressor function in several types of human cancers, but its non-small cell lung cancer (NSCLC) remains unknown. This study intended to investigate the biological role and clinical significance NSCLC. was detected by qRT-PCR, correlation with clinicopathological features NSCLC analyzed. The expression knocked down or ectopically expressed cells (A549 H1299) tumor growth, migration invasion vitro were investigated. In addition, interaction...

Rationale: The synergism of new modalities alongside chemodynamic therapy into common chemotherapy has shown promising potential in clinical applications. This paper reports a tumor microenvironment-responsive nanosystem for chemodynamic/chemical synergistic and magnetic resonance imaging (MRI). Methods: biodegradable is synthesized using surface-modified chain transfer agent surface-initiated living radical polymerization the chemotherapeutic drug. Results: In this nanosystem, named...

Non-small cell lung cancer (NSCLC) is the main type of with high mortality worldwide. To improve NSCLC therapy, exploration molecular mechanisms involved in progression and identification their potential therapy targeting important. Long noncoding RNAs (lncRNAs) have shown important roles regulating various tumors progression, including NSCLC. We found lncRNA GHRLOS was decreased lines tissues which correlated poor prognosis patients. However, role underlying remains elusive. The expression...

A great deal of evidence suggests that long non-coding RNAs (lncRNAs) function in the tumorigenesis retinoblastoma (RB). However, roles lncRNA ILF3-AS1 RB are still unclear. In present study, our work revealed was increased both tissues and cell lines. Repression suppressed proliferation invasion vitro. also promoted tumor growth vivo. While exploring mechanisms behind RB, we identified sponges with miR-132-3p is expressed at low levels as well attenuates progression. Furthermore, SMAD2...

Background and Aims The diagnostic standard of coronary artery disease (CAD) is angiography (CAG). Since CAG an invasive procedure underscores the need for identifying non-invasive, effective, innovative biomarkers. Our study aimed to retrospectively analyze hematological markers predicting severity CAD. Methods Results Case data were collected from 195 CAD patients admitted hospital CAG. According Gensini score, divided into mild, moderate, severe groups. Blood indexes predictive efficacy...

The study aimed to ascertain whether a diagnostic strategy combining D-dimer with the neutrophil-to-lymphocyte ratio (NLR) could improve discriminative performance for aortic dissection (AD).Baseline levels of and NLR were measured in patients suspected AD. clinical usefulness D-dimer, NLR, their combination assessed compared using receiver operating characteristics (ROC) curve analysis, logistic regression net reclassification improvement (NRI), integrated discrimination (IDI), decision...

Mesoscale eddies are of utmost importance in understanding ocean dynamics and the transport heat, salt, nutrients. Accurate representation these models is essential for improving model predictions. However, accurately representing mesoscale features numerical challenging due to their relatively small size. In this study, we propose a convolutional neural network (CNN) that combines data-driven techniques with physical principles develop robust interpretable parameterization scheme modeling....

To investigate the role of nicotine on proliferation and cell apoptosis in SCC15 oral squamous carcinoma cells.The growth, apoptosis, reactive oxygen species (ROS) level nuclear factor kappalight-chain-enhancer activated B (NF-κB) DNA binding activity were detected cancer using methly thiazolyl tetrazolium assay, flow cytometry, enzyme linked immunosorbent assay.In cells treated with for 48 h at different concentrations (0.1, 1, 10 µmol/L) ROS was (98.24 ± 0.04)%, (98.50 0.06)%, (98.61...

Ocean forecasting is critical for various applications and essential understanding air-sea interactions, which contribute to mitigating the impacts of extreme events. State-of-the-art ocean numerical systems can offer lead times up 10 days with a spatial resolution kilometers, although they are computationally expensive. While data-driven models have demonstrated considerable potential speed, often primarily focus on variations while neglecting temporal dynamics. This paper presents...

The present study is to explore the material basis and mechanism of Erzhi Wan prevented Alzheimer's disease by using network pharmacology. key target was docked with compounds, drugs-target combined target-signal pathway model established Cytoscape 3.2.1 software. Thirty compounds have a strong interaction three pathways related Wnt, MAPK PI3K-Akt-mTOR. There are 5 ingredients such as quercetin,geraniol,beta-sitosterol,nerol,eriodictyol that could be verified from literature.This result...

Pulmonary artery hypertension (PAH) is a common complication of congenital heart disease (CHD) and associated with worse outcomes increased mortality. The Doppler echocardiography (DE) commonly used imaging tool for both diagnosis follow-up examination PAH. Here to evaluate the diagnostic performance DE combined NTproBNP/BNP as screening strategy in PAH patients CHD.A retrospective study 64 CHD has been carried out compare estimate pulmonary systolic pressure (PASP) measured that right...

Previous intercultural communication research has relatively underplayed the influence of second language factors. This underplaying arises for three reasons: 1) over-emphasis on cultural differences in communication; 2) prevalent assumption that style is same as intra-cultural 3) dominant (post-) positive approach leading to overlooking linguistic factors and context. paper reports an exploratory study by taking interpretive approach. It shows process dealing with difficulties Australia,...

To observe and compare the differences in von Willebrand factor antigen (vWF:Ag) levels between patients with acute myocardial infarction (AMI) healthy residents, to determine whether this measure can be used evaluate incidence of AMI or not undertake cardiac bypass surgery.A retrospective analysis was conducted using clinical data 110 cardiovascular disease without (no group), 351 (bypass 60 volunteers (healthy group) who underwent physical examination July 2018 May 2019 Tianjin Chest...

Face negotiation theory has been an influential of intercultural conflict management. However, as a functional approach, it limitations in analyzing dynamic management process. Using repeated episodic interviews, this paper attempts to combine with Spencer-Oatey’s (2007) face and identity model well post-structural perspectives analyze the complicated process two Chinese overseas students’ cases. The findings reveal that are critical spell out dynamics complexity examining motives reasons...

目的 通过添加 O-羧甲基壳聚糖（oxygen-carboxymethylated chitosan，O-CMC）和庆大霉素对硫酸钙骨水泥（calcium sulfate cement，CSC）进行改性，提高其在骨修复领域应用的可行性。 方法 通过在 CSC 液相中添加不同浓度 O-CMC（0.1wt%、0.3wt%、0.5wt%、0.7wt%、1.0wt%），制备 O-CMC/CSC。通过可注射性、抗压强度、降解率、模拟体液 pH 值及Ca2+ 浓度测试、成分与形貌表征观察以及细胞毒性测试，分析 O-CMC 浓度对 在可注射性、抗压强度、降解行为及成骨活性方面的影响。综合以上检测指标，确定最佳性能的 O-CMC/CSC，并以此复合不同浓度庆大霉素（0.5wt%、1.5wt%、2.5wt%），探究其抗压强度和抗菌性。 结果 O-CMC/CSC 可注射时间均超过 5 min，且随 浓度的增加而显著延长（P 0.05）。浸泡液 值变化在 7.2～7.4 之间，Ca2+ 浓度稳定在 6～8 mmol/L。成分与形貌表征观察显示，相比于 CSC，O-CMC/CSC...

Objective To detect the changes and clinical significance in plasma protein-complement factor H-related protein 2 (CFHR2) pulmonary arterial hypertension (PAH) associated with congenital heart disease (CHD) children. Methods Various types of 66 CHD patients or without PAH 16 healthy children(healthy control group) were studied, including 11 ventricular septal defects(VSD) (VSD-PAH), isolated VSD, atrial defects (ASD-PAH), ASD, mixed type [two more ASD patent ductus arteriosus (PDA)]...