A5101992818- Medicinal Plants and Neuroprotection
- Alzheimer's disease research and treatments
- Pharmacological Effects of Natural Compounds
- Neuroinflammation and Neurodegeneration Mechanisms
- Natural product bioactivities and synthesis
- Molecular Sensors and Ion Detection
- Luminescence and Fluorescent Materials
- Synthesis of Organic Compounds
- Cholinesterase and Neurodegenerative Diseases
- Analytical chemistry methods development
- Catalytic C–H Functionalization Methods
- Catalytic Alkyne Reactions
- Chromatography in Natural Products
- Advanced biosensing and bioanalysis techniques
- Phytochemical compounds biological activities
- Crystallization and Solubility Studies
- Food Quality and Safety Studies
- Phytochemical Studies and Bioactivities
- Phytochemistry and Biological Activities
- X-ray Diffraction in Crystallography
- Circadian rhythm and melatonin
- GABA and Rice Research
- Mass Spectrometry Techniques and Applications
- Computational Drug Discovery Methods
- Neurological Disease Mechanisms and Treatments
Jiangxi University of Traditional Chinese Medicine
2011-2025
Foshan University
2024
Lingnan Normal University
2016-2023
Anyang Normal University
2023
Zhangzhou Vocational and Technical College
2022
Shenzhen University Health Science Center
2022
First Affiliated Hospital of Fujian Medical University
2018
Fujian Medical University
2018
Guangzhou University of Chinese Medicine
2017
Hainan Medical University
2016-2017
Okadaic acid (OA)‑induced neurotoxicity may be considered a novel tool used to study Alzheimer's disease (AD) pathology, and helpful in the development of therapeutic approach. It has been reported that galangin inhibits β‑site amyloid precursor protein‑cleaving enzyme 1 expression, which is key for β (Aβ) generation potential drug candidate AD therapy. However, further studies are required confirm its neuroprotective effects other models. The present aimed explore on OA‑induced PC12 cells....
Alzheimer's disease (AD) is a common neurodegenerative in the elderly population. Autophagy well‑known regulator of diseases and β‑asarone has been discovered to have certain neuropharmacological effects. Thus, present study aimed analyze potential effects AD its possible mechanism action relation autophagy. The investigated on number senile plaques amyloid β(Aβ)40, Aβ42, precursor protein (APP) Beclin‑1 mRNA levels hippocampus APP/presenilin‑1 (PS1) transgenic mice. autophagy‑related...
Using Au catalyst and ethyl Hantzsch ester as a hydrogen source, 3-(1-alkynyl)chromones were directly transformed to 4H-benzofuro[3,2-c]pyrans in good excellent yields through cascade process by addition, cyclization transfer under mild conditions.
Okadaic acid (OA) can be used to induce an Alzheimer's disease (AD) model characterized by tau hyperphosphorylation, the formation of neurofibrillary tangles and β‑amyloid (Aβ) deposition. Previous studies have shown that upregulation Beclin‑1‑dependent autophagy may contribute elimination aggregated Aβ. However, effects protocatechuic (PA) on levels Aβ42, phosphorylated (p)‑tau β‑secretase in OA‑induced cell injury are unclear, little is known concerning role PA signaling pathway regulation...
Abstract Sarcosine is a potential prostate cancer marker. In this study, we developed method of three‐phase solvent bar liquid‐phase microextraction combined with high‐performance liquid chromatography to determine sarcosine after derivatization 4‐dimethylarminoazobenzene‐4‐sulfonyl chloride from human urine. The effects different extraction conditions on efficiency were investigated and optimized. Under optimum experimental conditions, calibration graph exhibited linearity over the range...
A new alkaloid polygonatine C (3-(2'-furaldehyde-5'-methoxymethyl)5,6,7,8 -tetrahydroindolizin-8-one, 1) and a saponin huangjingsterol B (3-β-hydroxyspirost-5,25-diene-12-one, 2), together with three known compounds 3-5 were isolated from the ethanolic extract of Stewed Polygonatum cyrtonema Hua. The structures these identified by extensive spectroscopic analysis including 1D 2D NMR MS, as well chemical methods. tested for their Protective effect against Aβ25-35 induced cytotoxicity...
Seven compounds, named β-sitosterol (
Alzheimer's disease (AD) is a neurodegenerative disorder with prominent individual morbidity and mortality among elderly people. Germacrone (Germ) has been reported to exert dominant protective roles in multiple human diseases, neurological diseases are also included. The intention of this paper determine the impacts Germ on okadaic acid (OA)-treated PC12 cells confirm hidden regulatory mechanism. First, were induced by OA absence or presence Germ. Cell counting kit-8 assay was monitor cell...
Poly(ADP-ribose) polymerase-1 (PARP1) is a potential biomarker and therapeutic target for cancers that can catalyze the poly-ADP-ribosylation of nicotinamide adenine dinucleotide (NAD+) onto acceptor proteins to form long poly(ADP-ribose) (PAR) polymers. Through integration with aggregation-induced emission (AIE), background-quenched strategy detection PARP1 activity was designed. In absence PARP1, background signal caused by electrostatic interactions between quencher-labeled PARP1-specitic...
A phytochemical investigation on the stems of Glycosmis puberula var. craibii led to isolation a new indole alkaloid (named glycosmiscrol A, 1), together with four known compounds (2-5). The structure was elucidated by detailed analysis comprehensive spectroscopic methods. All isolated were evaluated for their antiproliferative activities against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480 in vitro. Compounds 1-5 showed significant effects IC50 values ranging from...