A5055793926- Oxidative Organic Chemistry Reactions
- Crystallization and Solubility Studies
- Synthesis of Organic Compounds
- X-ray Diffraction in Crystallography
- Catalytic C–H Functionalization Methods
- Chemical Synthesis and Reactions
- Multicomponent Synthesis of Heterocycles
- Synthesis and Biological Evaluation
- Synthesis of Indole Derivatives
- Catalytic Alkyne Reactions
- Lipid metabolism and biosynthesis
- HIV/AIDS drug development and treatment
- Cancer therapeutics and mechanisms
- Pneumocystis jirovecii pneumonia detection and treatment
- HIV Research and Treatment
- Cancer, Hypoxia, and Metabolism
- Chemical Reaction Mechanisms
- Synthetic Organic Chemistry Methods
- Petroleum Processing and Analysis
- Traditional and Medicinal Uses of Annonaceae
- Click Chemistry and Applications
- Adipose Tissue and Metabolism
- Enhanced Oil Recovery Techniques
- Ubiquitin and proteasome pathways
- Hydrocarbon exploration and reservoir analysis
Xinxiang Medical University
2015-2022
Shanghai Institute of Materia Medica
2010-2017
Chinese Academy of Sciences
2010-2017
Henan Normal University
2016
Xinxiang University
2015-2016
Henan Institute of Technology
2016
Green Chemistry
2016
Akita University
1988
An efficient, palladium-catalyzed cascade reaction, which leads to formation of annulated xanthones, was devised. The process, uses readily available 3-iodochromones, aryl iodides and norbornadiene as starting materials, takes place via a tandem Heck reaction/double C–H activation/retro-Diels–Alder pathway. high chemoselectivity the process is mechanistically unique it serves new approach achieve regioselective control activation in Pd/norbornene or systems. Its broad substrate scope,...
NH aldimines, generated in situ from the corresponding aldehydes by reaction with ammonium acetate, serve as nitrogen nucleophiles reactions 3-(1-alkynyl)chromones and 3-cyanochromones that generate functionalized azaxanthones. These processes take place under mild conditions do not require dry solvents. The products of described represent new chemical entities. We believe newly developed cascade process will a potent method for synthesis N-heterocycles diversity-oriented synthesis.
Using Au catalyst and ethyl Hantzsch ester as a hydrogen source, 3-(1-alkynyl)chromones were directly transformed to 4H-benzofuro[3,2-c]pyrans in good excellent yields through cascade process by addition, cyclization transfer under mild conditions.
A novel Friedel–Crafts reaction of indoles with vicinal tricarbonyl compounds generated <italic>in situ</italic> has been developed, forming indolyl tertiary alcohols. The process involves disproportionation TEMPO, α-oxyamination, N–O bond cleavage and, finally, addition the indole.
The reaction of indole and β-carbonyl nitrile to generate dicarbonyl indoles has been developed. This process involves α-oxonation the nitrile, Friedel–Crafts with retro-cyanohydrination form indoles.
A mild oxidative sequential tandem reaction was developed to rapidly generate 2-aryl-3-(2-aminoaryl) quinoxalines. This method exploited 2-substituted indoles as substrate form quinoxalines in a one-pot reaction. The key this the formation of 3-iodoindoles, which underwent Kornblum-type oxidation with DMSO active imine 2-substitued 3H-indol-3-ones. imines were captured situ by 1,2-diaminobenzenes construct diverse transformation can be accomplished at room temperature excellent functional...
Abstract 3(2 H )‐Furanones are efficiently generated from 3‐alkynyl oxireno[2,3‐ b ]chromenones by an Au/DDQ‐catalyzed domino reaction through a pathway composed of cyclization, CC cleavage, nucleophilic addition, oxidation, and addition. It was found that stoichiometric AuCl 3 or catalytic Au with DDQ can oxidize the benzylic sp CH bond to facilitate
A series of triazole derivatives bergenin were synthesised through the nucleophilic substitution reaction and propargyl bromide, following click with different azides. Their antitumour activities evaluated against EC9706, MGC803 B16 in vitro. Several compounds showed potent anti-tumour activity, especially (2S,3R,4R,4aS,10bR)-8,10-bis{{1-[4-(tert-butyl)benzyl]-1H-1,2,3-triazol-4-yl} methoxy}-3,4-dihydroxy-2-(hydroxymethyl)-9-methoxy-2,3,4,4a-tetrahydropyrano[3,2-c]isochromen-6(10bH)-one, IC...
A series of lamiridosin derivatives were synthesized through simple procedures. Their antitumor activities evaluated against EC9706, MGC803, and B16 cell lines in vitro. Several compounds showed potent activity, especially compound 10, with IC50 value 2.36 μmol/L MGC803 lines, is more than marketed positive drug 5-fluorouridine (5-FU).
Abstract The reaction is proposed to proceed via an initial Heck followed by a sp 2 ‐sp 3 ‐coupling, reductive elimination and final retro‐Diels—Alder step.
Abstract An efficient gold‐catalyzed domino reaction producing functionalized furanones via a proposed sequence of cyclization, C‐C cleavage, nucleophilic addition, oxidation, and is reported.
Abstract Some of the title compounds (I) show strong antiviral activities.
Abstract A new, mild, and efficient method to prepare substituted 2‐aza‐ 2,4‐diazaxanthones is reported.