A5100430809- Lung Cancer Research Studies
- Brain Metastases and Treatment
- Pulmonary Hypertension Research and Treatments
- Glioma Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Cardiovascular Disease and Adiposity
- Nanoplatforms for cancer theranostics
- Photodynamic Therapy Research Studies
- Lung Cancer Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Ovarian cancer diagnosis and treatment
- Atrial Fibrillation Management and Outcomes
- Analytical Chemistry and Chromatography
- Cardiac Arrhythmias and Treatments
- Cardiovascular Issues in Pregnancy
- Renin-Angiotensin System Studies
- Aortic aneurysm repair treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Glycosylation and Glycoproteins Research
- Computational Drug Discovery Methods
- Antioxidant Activity and Oxidative Stress
- Genital Health and Disease
- Nitric Oxide and Endothelin Effects
- Ginseng Biological Effects and Applications
Jinhua Academy of Agricultural Sciences
2025
Zhejiang University
2025
Army Medical University
2023
Chongqing Medical University
2023
Second Affiliated Hospital of Chongqing Medical University
2023
Dalian Medical University
2023
Third Xiangya Hospital
2022
Central South University
2022
Second Hospital of Shanxi Medical University
2022
Shanxi Medical University
2012-2022
L-arginine can attenuate pulmonary hypertension (PH) by a mechanism that are not fully understood. This study investigated the molecule of attenuating PH. Sprague Dawley rats were treated with monocrotaline (MCT) or without for 3 5 wk. Right ventricular systolic pressure (RVSP), right heart hypertrophy, survival rate, artery wall thickness, nitric oxide (NO) concentration, and superoxide anion (O(2)(*-)) generation in lung measured. Expressions endothelial synthase (eNOS) heat shock protein...
Mitral valve endothelial cells are important for maintaining lifelong mitral integrity and function. Plasma microparticles (EMPs) increased in various pathological conditions related to activation of cells. However, whether EMPs will increase disease their relationship remains unclear. Here, 81 patients with 45 healthy subjects were analyzed the generation by flow cytometry. Human (HMVECs) treated EMPs. The phosphorylation Akt nitric oxide synthase (eNOS), association eNOS heat shock protein...
Photodynamic therapy (PDT), performed with low-fluence rates, can improve antitumor responses and prevent adverse effects. However, photosensitizers (PSs) for PDT treatment are rarely reported. Herein, we exploited an amphiphilic chlorin-based PS, named DYSP-C34, which has a variety of beneficial biological properties, such as improved water solubility, better cellular permeability, specific localization enhanced phototoxicity under low light dose irradiation. In addition, DYSP-C34 could...
The definitive validation evidence of the implications lymph node metastases regarding survival Non-Small Cell Lung Cancer (NSCLC) patients is lacking. We aimed to evaluate prognostic impact several metastases-associated risk factors including Number Negative Lymph Node (NLN) and risk-stratify NSCLC into subsets with different prognosis.A total 482 N1 N2 were included in this study. importance a set was examined by univariate multivariate analysis. cut-off points 5 years rates calculated...
A series of novel caffeoylquinic acid derivatives chlorogenic have been designed and synthesized. Biological evaluation indicated that several synthesized exhibited moderate to good lipid-lowering effects on oleic acid-elicited lipid accumulation in HepG2 liver cells. Particularly, 3d, 3g, 4c 4d more potential effect than the positive control simvastatin acid. Further studies mechanism revealed were related their regulation TG levels merit further investigation.
Background. The SOX gene family has been proven to display regulatory effects on numerous diseases, particularly in the malignant progression of neoplasms. However, molecular functions and action mechanisms genes have not clearly elucidated clear cell renal carcinoma (ccRCC). We aimed explore expression status, prognostic values, clinical significances, actions ccRCC. Methods. RNA-sequence data information derived from Cancer Genome Atlas (TCGA) database was used for this study. Dysregulated...
Purpose This study tried to evaluate whether advanced age has an increased incidence of major complications in patients undergoing MCA stenting. Methods A total 348 who underwent stenting were reviewed from a prospectively maintained database. Ninety-day ischemic stroke, intracerebral hemorrhage, and death outcomes compared among the young (≤40 years old), middle (41–60 old) old (≥61 groups. Univariate analysis multivariable logistic regression used investigate different variables associated...
Abdominal aortic aneurysm (AAA), defined as a localized dilatation of abdominal aorta, is significant cause morbidity and mortality in aging populations. AAA life-threatening disease mainly because the high fatality rates associated with rupture. Early detection AAAs will provide patients an opportunity to receive medical therapy undergo elective repair before Historically, considered macrovascular atherosclerotic disease. Classic risk factors atherosclerosis, such advanced age, male gender,...
Abstract Background and purpose To evaluate the clinical outcomes of hypofractionated stereotactic radiotherapy (HFSRT) combined with whole brain (WBRT) in patients metastases (BMs). Materials methods From May 2018 to July 2020, 50 (111 lesions) received HFSRT (18 Gy/3F) + WBRT (40 Gy/20F). The RECIST 1.1 RANO-BM criteria were used treatment efficacy. Five prognostic indexes (RPA, GPA, SIR, BS-BM, GGS) applied. primary endpoint was intracranial local control (iLC). Secondary endpoints...
Background Anaplastic lymphoma kinase (ALK) rearrangement is a common driver gene of non-small cell lung cancer (NSCLC). Ceritinib second-generation ALK inhibitor, which can bring survival benefits to ALK-positive metastatic NSCLC. However, few studies focus on the safety and efficacy ceritinib in China. Therefore, this study intends investigate preliminary 450 mg with meals Chinese patients NSCLC through real world study. Methods From October 2018 December 2019, from 8 medical centers...
e18033 Background: Endostar is a recombinant human endostatin. We conducted multi-centre trial to investigate the efficacy and safety of plus GP with maintenance as first- line therapy for advanced NSCLC Methods: Chemotherapy-naïve patients histologically or cytologically confirmed, measurable, stage ‡W were enrolled from 11 centers in China. All received gemcitabine 1,000 mg/m2 (days 1 8) cisplatin 25 1-3) every 21 days. Patients achieving objective response disease stabilization following...
Objective To detect the changes and clinical significance in plasma protein-complement factor H-related protein 2 (CFHR2) pulmonary arterial hypertension (PAH) associated with congenital heart disease (CHD) children. Methods Various types of 66 CHD patients or without PAH 16 healthy children(healthy control group) were studied, including 11 ventricular septal defects(VSD) (VSD-PAH), isolated VSD, atrial defects (ASD-PAH), ASD, mixed type [two more ASD patent ductus arteriosus (PDA)]...
Abstract Background and purpose To evaluate the clinical outcomes of hypofractionated stereotactic radiotherapy (HFSRT) combined with whole brain (WBRT) in patients metastases (BMs). Materials methods From May 2018 to July 2020, 50 (111 lesions) received HFSRT (18Gy/3F) + WBRT (40Gy/20F). The RECIST 1.1 RANO-BM criteria were used treatment efficacy. Five prognostic indexes (RPA, GPA, SIR, BS-BM, GGS) applied. primary endpoint was intracranial local control (iLC). Secondary endpoints overall...
Abstract Background and purpose : To evaluate the clinical outcomes of hypofractionated stereotactic radiotherapy (HFSRT) combined with whole brain (WBRT) in patients metastases (BMs). Materials methods From May 2018 to July 2020, 50 (111 lesions) received HFSRT (18Gy/3F) +WBRT (40Gy/20F). The RECIST 1.1 RANO-BM criteria were used treatment efficacy. Five prognostic indexes (RPA, GPA, SIR, BS-BM, GGS) applied. primary endpoint was intracranial local control (iLC). Secondary endpoints overall...