Protein ubiquitination occurs when the ubiquitin protein binds to a target residue of lysine (K), and it is an important regulator many cellular functions, such as signal transduction, cell division, immune reactions, in eukaryotes. Experimental clinical studies have shown that plays key role several human diseases, recent advances proteomic technology spurred interest identifying sites. However, most current computing tools for predicting sites are based on small-scale data shallow machine...

We present the China Ocean ReAnalysis version 2 (CORA2) in this paper. compare CORA2 with its predecessor, CORA1, and other ocean reanalysis products created between 2004 2019 [GLORYS12v1 (Global Simulation), HYCOM (HYbrid Coordinate Model), GREP Reanalysis Ensemble Product), SODA3 (Simple Data Assimilation, 3), ECCO4 (Estimating Circulation Climate of Ocean, 4)], to demonstrate improvements reliability. In addition providing tide sea ice signals, accuracy eddy kinetic energy (EKE) are also...

Abstract Nanozymes, as substitutes for natural enzymes, are constructed cascade catalysis systems biomedical applications due to their inherent catalytic properties, high stability, tunable physicochemical and environmental responsiveness. Herein, a multifunctional nanozyme is reported initiate enzymatic reactions specific in acidic environments resistant Helicobacter pylori ( H. ) targeting eradication. The cobalt‐coated Prussian blue analog based FPB‐Co‐Ch NPs displays oxidase‐, superoxide...

With the rapid development of nanotechnology, researchers have designed a variety intelligent nanodelivery systems to enhance tumor targeting anticancer drugs. However, increased accumulation does not indicate deeper penetration in tissue, without which cells core area cannot be sufficiently killed. Herein, we develop size-controllable nanoparticle system for deep-penetrating cancer therapy, will programmably disassembled with decrease pH from normal tissue microenvironment and intracellular...

With increasing air and sea temperatures, the thermodynamic environments over oceans are becoming more favourable for development of intense tropical cyclones (TCs) with rapid intensification (RI). The South China coastal region consists highly densely populated cities, especially Pearl River Delta (PRD) region. Intense TCs maintaining their strength or RI close to can present substantial forecasting challenges have significant potential impacts on population. This study investigates effect...

This study systematically investigated the ocean mixed layer responses to tropical cyclone (TC) using available Argo profiles during period of 1998–2011 in northwest Pacific. Results reveal that isothermal (IL) deepening and cooling with evident rightward biases induced by strong TCs are clearer compared weak TCs. Likewise, IL fast more obvious than slow The upwelling within TC's eye is much stronger for (slow) (fast) For TCs, TC-induced rainfall reduces constant density (with its depth...

Abstract Strong winds lead to large amounts of sea spray in the lowest part atmospheric boundary layer. The droplets affect air‐sea heat fluxes due their evaporation and momentum change surface, turn upper ocean thermal structure. In this study, impact on temperatures Yellow East China Seas (YES) during typhoon Rammasun's passage is investigated using POMgcs model with a parameterization scheme, which spray‐induced are based an improved Fairall's algorithm, derived from COARE version 2.6...

Understanding the sea level variability of Bohai, Yellow Sea, and East China Sea (BYECS) is crucial for socio-cultural natural ecosystems coastal regions. In this study, based on satellite altimetry data, selected time range from 1993 to 2020, using cyclostationary empirical orthogonal function (CSEOF) analysis method distinguishes primary modes. The encompasses seasonal signal, trend, El Niño-Southern Oscillation (ENSO) associated mode anomaly. amplitude annual cycle demonstrates a...

In recent years, scientists have found a close correlation between DNA methylation and aging in epigenetics. With the in-depth research field of methylation, researchers established quantitative statistical relationship to predict individual ages. This work used human blood tissue samples study association age methylation. We built two predictors based on healthy disease data, respectively. For health we retrieved total 1191 from four previous reports. By calculating Pearson coefficient...

Abstract The accumulated remote sensing data of altimeters and scatterometers have provided new opportunities for ocean state forecasting improved our knowledge ocean–atmosphere exchanges. Studies on multivariate, multistep, spatiotemporal sequence forecasts sea level anomalies (SLA) different modalities, however, remain problematic. In this paper, we present a novel hybrid multivariate deep neural network, named HMnet3, which can be used SLA in the South China Sea (SCS). First, network is...

The northern part of the South China Sea is a complex ocean environment with large range tidal waves and stable Luzon cold eddy, which significantly influence sound propagation characteristics through their impact on speed. This study uses 3D ocean-acoustic framework consisting MITgcm BELLHOP ray model to investigate coupled effects eddy waves. Firstly, incorporates assimilation reconstruct hydrographic field compute speed field. Subsequently, in representative region simulated compare...

Helicobacter pylori (H. pylori) infection presents increasing challenges to antibiotic therapies in limited penetration through gastric mucus, multi-drug resistance (MDR), biofilm formation, and intestinal microflora dysbiosis. To address these problems, herein, a mucus-penetrating phototherapeutic nanomedicine (RLs@T780TG) against MDR H. is engineered. The RLs@T780TG assembled with near-infrared photosensitizer T780T-Gu an anionic component rhamnolipids (RLs) for deep mucus light-induced...

With global warming, extreme high temperatures become more frequent and are an important factor affecting aircrafts’ takeoff performance. Using Community Earth System Model version 1 (CESM1) Boeing Performance Software (BPS), the influence of increasing temperature on maximum weight (MTOW) distance is evaluated quantitatively in this study. The results show that distribution summer daily shifts obviously to higher at all chosen airports variation larger four (Jinan, Shanghai, Lhasa, Urumqi)...

In-situ observation is restricted by the strong wind and waves in Southern Ocean. A Westerlies Environmental Monitoring Buoy (WEMB) was firstly deployed Ocean during China's 35th Antarctic Expedition, facilitating further understanding of oceanic environmental characteristics this region. With development technology improvement data processing methods, accuracy satellite altimeter products constantly improved, thus making it possible to inspect evaluate in-situ data. Based on L3 multiple...

Arctic coastal polynyas, defined here as persistent openings in the winter sea ice pack, are significant areas for ocean–atmosphere heat exchange, high production with resulting brine rejection and dependence of local ecosystems. It is therefore critical to accurately quantify polynya dynamics understand their spatial temporal variability, particularly context recent dramatic declines. In this study, so-called erosion algorithm (a greyscale morphology image-processing technique) applied...

China Ocean ReAnalysis (CORA) version 1.0 products for the period 2009–18 have been developed and validated. The model configuration assimilation algorithm both updated compared to those of 51-year (1958–2008) products. assimilated observations include temperature salinity field data, satellite remote sensing sea surface temperature, merged height (SSH) anomaly data. validation includes following three aspects: (1) Temperature, salinity, SSH root-mean-square errors (RMSEs) are computed as a...