The high incidence of recurrence and malignant transformation colorectal adenoma (CRA) are current issues that need to be addressed in clinical practice. Canmei Formula (CMF) has shown promising results the prevention treatment, however, it lacks effective data support its mechanism action is not fully elucidated. aim this study evaluate efficacy safety CMF preventing treating CRA, explore chemical components pharmacological mechanisms. A randomized controlled trial was conducted, with...

With the rapid development of nanotechnology, researchers have designed a variety intelligent nanodelivery systems to enhance tumor targeting anticancer drugs. However, increased accumulation does not indicate deeper penetration in tissue, without which cells core area cannot be sufficiently killed. Herein, we develop size-controllable nanoparticle system for deep-penetrating cancer therapy, will programmably disassembled with decrease pH from normal tissue microenvironment and intracellular...

The magnetic particles have a significant influence on the immunoassay detection and cancer therapy. Herein, chemiluminescence combined with (MPCLIA) was presented for clinical determination analysis of human epididymis protein 4 (HE4) in serum. Under optimized experiment conditions, secure MPCLIA method can detect HE4 broader range 0–1000 pmol/L, lower limit 1.35 pmol/L. satisfactory recovery rate serum ranged from 83.62% to 105.10%, which well within requirement analysis. Moreover, results...

Ochratoxin A (OTA) is a harmful mycotoxin and secondary metabolite produced by several species of Aspergillus Penicillium. It vital importance to establish sensitive method detect OTA in various grains.A novel, highly chemiluminescence immunoassay was developed determine wheat, corn, poultry feed.The immunomagnetic beads were used as solid phase carriers separators the competitive method. Anti-OTA monoclonal antibodies coated on magnetic applied capturing antibodies, which would compete with...

We designed nanofibrous hydrogels as 2-D and 3-D scaffolds for anchorage-dependent cells. The IKVAV-containing peptide amphiphile molecules spontaneously self-assembled into higher-order nanofiber under cell-containing media. Neural progenitor cells (NPCs) were incubated in peptide-based hydrogels. Effects of self-assembling on survival neural differentiation NPCs observed. Peptide was synthesized using a solid-phase method. TEM study the hydrogel revealed network nanofibers. Phase-contrast...

The elbow is one of the most mobile joints, and its movement very important. Bony ankylosed an uncommon condition leading to complete loss activity elbow, then lead severe disability limitation in activities daily living.

Abstract We aimed to establish an automated versatile sample preconcentration method based on the modified immunomagnetic beads, which was utilized enrich for aflatoxin B1 from matrices. The critical main parameters affecting extraction efficiency, such as usage amount of reaction time, elution and blending way were investigated. Under optimized conditions, content analyzed by high‐performance liquid chromatography, mobile phase consists water–acetonitrile–methanol (42:18:10, v/v/v),...

Osteoarthritis seriously affects the health of elderly individuals. In this study, hyaluronic acid–gold nano-optical probes (HA–GNPs) were prepared, and their effect on osteoarthritis its underlying mechanism explored. The HA–GNPs synthesised via a one-step synthesis method characterised detected ultraviolet–visible spectrophotometry, dynamic light scattering (particle size analysis), zeta potential analysis, scanning transmission electron microscopy. cytotoxicity was determined using CCK-8...

Abstract Objectives Pituitary abscess (PA) accounts for only 0.3–0.5% of sellar masses, and the lack specific clinical symptoms makes diagnosing PA difficult without a surgical biopsy. In practice, is often mistaken cystic pituitary adenoma, craniopharyngioma, Rathke’s cyst. Thus, this study aims to investigate challenges in evaluate importance combining intraoperative surgery with postoperative antibiotic treatment. Methods We conducted retrospective analysis 19 patients diagnosed through...

Abstract Background Total hip arthroplasty (THA) is the most effective treatment for severe disease. Orthopedic surgeons prefer using Direct Anterior Approach (DAA) technique THA as it muscle-sparing and less invasive joint. It noted that muscular damage, especially to tensor fascia lata muscle (TFLM), elicits an inflammatory response, negating DAA's beneficial effects. To prevent damage TFLM reduce inflammation during surgical procedures, a specialized retractor was explicitly developed...

Pituitary abscess (PA) is a rare disease in the sellar region. This study aimed to investigate series of PA cases with two different approaches better understand surgical principles and underlying mechanisms. 19 primary were included for comprehensive evaluation special attention paid effectiveness safety or without sella packing. Headache, visual impairment most frequently seen symptoms among all patients. More than half patients exhibited anterior pituitary dysfunction including...

Herein, a magnetic bead-based chemiluminescence assay is reported to detect type IV collagen (col-IV) in serum samples.

Background: Colorectal adenoma represents the critical step in development of colorectal cancer. The establishment an immortalized epithelial cell line human origin would provide a tool for studying mechanism precancerous lesions, screening efficacy novel drugs, and constructing vivo disease models. Currently, there is no commercially available stable supply cells from lesions. Aims: This study aimed to establish natural LHPP low-expressing by SV40-LT antigen gene transfection. Methods:...

To investigate the clinical improvement of limping gait in patients with ankylotic hips and limb length discrepancy.From 1996 to 2005, 12 discrepancy were treated by distraction osteogenesis a mono-lateral external fixator an intramedullary nail. The was 6.20-12.50 (median 8.45) cm. Limping classified according recommendations American Academy Orthopedic Surgeons/Hip Society scored Harris: no 11 points, mild 8 moderate 5 while severe 0 points. all pre-operatively total score 0.All followed...

Perioperative visual loss (POVL) is an infrequent, devastating complication. Increased recognition and discussion of this complication reported in recent literature, most notably following spinal cardiac surgery. The common causes are ischemic optic neuropathy, central retinal artery occlusion, cortical blindness. Here, we present a case 54 y old female who developed acute her eyes after lateral position total hip arthroplasty that might explain

Kidney injury molecule 1 (KIM-1) is markedly upregulated in the proximal tubule after and maladaptive when chronically expressed. A practical sensitive chemiluminescence immunoassay combined with magnetic bead separation for determination of KIM-1 human urine has been developed. Based on a sandwich-type immunoassay, analyte captured by monoclonal antibodies (mAb) coated beads those labeled alkaline phosphatase. The changes concentration levels were monitored CLIA early diagnosis kidney...

Objective To evaluate the effectiveness of an interactive entertainment via a tablet computer (TC) to manage children's perioperative anxiety. Methods The study was limited children who accepted circumcision with local anesthesia nerve block. 204 patients were divided into intervention group, those played TC in waiting room and operating room, control didn't play according random number table method. Preoperative anxiety measured by Modified Yale Anxiety Scale (mYPAS) on day before...