A5046845783- Nanoplatforms for cancer theranostics
- Advanced biosensing and bioanalysis techniques
- Luminescence and Fluorescent Materials
- RNA Interference and Gene Delivery
- Molecular Sensors and Ion Detection
- Photodynamic Therapy Research Studies
- Helicobacter pylori-related gastroenterology studies
- Biosensors and Analytical Detection
- Gold and Silver Nanoparticles Synthesis and Applications
- Neuroendocrine Tumor Research Advances
- Photoacoustic and Ultrasonic Imaging
- Cancer, Hypoxia, and Metabolism
- Bacteriophages and microbial interactions
- Heme Oxygenase-1 and Carbon Monoxide
- ATP Synthase and ATPases Research
- Gastroesophageal reflux and treatments
- Glycosylation and Glycoproteins Research
- Cytomegalovirus and herpesvirus research
- Immunotherapy and Immune Responses
- Ocular Oncology and Treatments
- Environmental Quality and Pollution
- Diverse Interdisciplinary Research Innovations
- Heat shock proteins research
- Microbial Inactivation Methods
State Key Laboratory of Medicinal Chemical Biology
2019-2024
Nankai University
2019-2024
Tianjin Chengjian University
2005
Zaozhuang University
2000
In recent years, cancer phototherapy has been extensively studied as noninvasive treatment. To present efficient recognition toward cells, most photosensitizers (PSs) are required to couple with tumor-targeted ligands. Interestingly, the heptamethine cyanine IR780 displays an intrinsic feature even without modification. However, photothermal efficacy and photostability of not sufficient enough for clinical use. Herein, we involve a twisted structure tetraphenylethene (TPE) between two...
Glucose, a critical source of energy, directly determines the homeostasis human body. However, due to lack robust imaging probes, mechanism underlying changes glucose in body remains unclear. Herein, diboronic acid probes with good biocompatibility and high sensitivity were synthesized based on an ortho-aminomethylphenylboronic probe, phenyl(di)boronic (PDBA). Significantly, by introducing water-solubilizing group -CN opposite boronic -COOCH3 or -COOH groups β site anthracene PDBA, we...
Mitochondria are crucial in the process of oxidative metabolism and apoptosis. Their morphology is greatly associated with development certain diseases. For specific long-term imaging mitochondrial morphology, we synthesized a new mitochondria-targeted near-infrared (NIR) fluorescent probe (TPE–Xan–In) by incorporating TPE NIR merocyanine skeleton (Xan–In). TPE–Xan–In displayed both absorption (660 nm) emission peaks (743 region. Moreover, it showed aggregation-induced properties at neutral...
Near-infrared (NIR) fluorescent probes can deeply penetrate through tissues with little damage. To facilitate image-guided theranostics, researchers usually apply a desired amount of photosensitizers to achieve effective photothermal responses. However, these could easily suffer from low photostability and aggregated-caused quenching effect in high concentrations. In this paper, the rational incorporation an aggregated-induced emission (AIE) unit into structure heptamethine cyanine IR-780 is...
Low-temperature photothermal therapy (PTT) has the advantage of causing less damage to normal tissues and attracted great attention in recent years. However, efficacy low-temperature PTT is restricted by overexpression heat shock proteins (HSPs), specifically HSP70 HSP90. Inhibiting function these HSPs a major strategy used development new cancer therapies. Herein, we designed four T780T-containing thermosensitive nanoparticles interrupt energy supply for HSP expression using their TPP-based...
Pyroptosis has been reported to improve the antitumor effect by evoking a more intense immune response and therapeutic effect. For phototherapy, several photosensitizers have found initiate pyroptosis. However, of pyroptosis associated with apoptosis in enhancing therapy needs sufficient characterization, especially under long-term treatment. As NIR photosensitizer, heptamethine cyanines discovered for anticancer phototherapy deep tissue penetration inherent tumor-targeted capability. they...
With the rapid development of nanotechnology, researchers have designed a variety intelligent nanodelivery systems to enhance tumor targeting anticancer drugs. However, increased accumulation does not indicate deeper penetration in tissue, without which cells core area cannot be sufficiently killed. Herein, we develop size-controllable nanoparticle system for deep-penetrating cancer therapy, will programmably disassembled with decrease pH from normal tissue microenvironment and intracellular...
Abstract Helicobacter pylori ( H. ) infection has been the leading cause of gastric cancer development. In recent years, resistance against antibiotic treatment a great challenge for most countries worldwide. Since biofilm formation is one reasons , and phototherapy emerged as promisingly alternative antibacterial treatment, herein bacteria‐targeted near‐infrared (NIR) photosensitizer (T780T‐Gu) by combining positively‐charged guanidinium (Gu) with an efficient phototherapeutic agent T780T...
Helicobacter pylori (H. pylori) infection presents increasing challenges to antibiotic therapies in limited penetration through gastric mucus, multi-drug resistance (MDR), biofilm formation, and intestinal microflora dysbiosis. To address these problems, herein, a mucus-penetrating phototherapeutic nanomedicine (RLs@T780TG) against MDR H. is engineered. The RLs@T780TG assembled with near-infrared photosensitizer T780T-Gu an anionic component rhamnolipids (RLs) for deep mucus light-induced...
Recently, nanoformulations have been widely applied in the delivery of organic photothermal agents (OPTAs) for cancer therapy to prolong blood circulation or improve tumor-targeting capacity. However, systematic evaluations their effects on behavior OPTAs are limited, especially different types nanoparticle systems. Herein, we prepared two kinds nanoparticles (BSA and PEG (NPs)) load an OPTA, a cyanine photosensitizer (IR780-O-TPE), investigated response, organelle targeting, vivo...