A5002715805- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Neural dynamics and brain function
- Sleep and Wakefulness Research
- Transcranial Magnetic Stimulation Studies
- Spaceflight effects on biology
- Stress Responses and Cortisol
- Photoreceptor and optogenetics research
- Ultrasound and Hyperthermia Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Functional Brain Connectivity Studies
- Anesthesia and Neurotoxicity Research
- Vagus Nerve Stimulation Research
- Alzheimer's disease research and treatments
- Acute Ischemic Stroke Management
- Electromagnetic Fields and Biological Effects
- Photoacoustic and Ultrasonic Imaging
- Spinal Cord Injury Research
- Neuroendocrine regulation and behavior
- Olfactory and Sensory Function Studies
- Circadian rhythm and melatonin
- Neurogenesis and neuroplasticity mechanisms
- Neuroscience and Neural Engineering
- Space Exploration and Technology
- Health, Environment, Cognitive Aging
Tianjin University
2019-2025
Tianjin Medical University
2020-2025
Human Computer Interaction (Switzerland)
2024-2025
Nankai University
2010-2022
Third Affiliated Hospital of Sun Yat-sen University
2022
State Key Laboratory of Medicinal Chemical Biology
2022
Sun Yat-sen University
2022
The University of Texas at Austin
2015-2021
Institute of Physics
1981-2004
Chinese Academy of Sciences
1998
The hippocampus supports a cognitive map of space and is critical for encoding declarative memory (who, what, when where). Recent studies have implicated hippocampal subfield CA2 in social contextual but how it does so remains unknown. Here we find that adult male rats, presentation stimulus (novel or familiar rat) novel object induces global remapping place fields with no effect on neuronal firing rate immediate early gene expression. This did not occur CA1, suggesting this specific CA2....
The experience-dependent spatial cognitive process requires sequential organization of hippocampal neural activities by theta rhythm, which develops to represent highly compressed information for rapid learning. However, how the sequences were developed in a finer time scale within cycles remains unclear. In this study, we found that sweep-ahead structure developing with exploration was predominantly dependent on relatively large proportion FG-cells, i.e. subset place cells dominantly...
In hippocampal area CA1 of rats, the frequency gamma activity has been shown to increase with running speed (Ahmed and Mehta, 2012). This finding suggests that different frequencies simply allow for timings transitions across cell assemblies at varying speeds, rather than serving unique functions. However, accumulating evidence supports conclusion slow (∼25-55 Hz) fast (∼60-100 are distinct network states If constitute states, then it is possible differentially affected by speed. this study,...
Abstract Hippocampal gamma rhythms increase during mnemonic operations (Johnson and Redish, 2007; Montgomery Buzsáki, Sederberg et al., Jutras 2009; Trimper 2014) may affect memory encoding by coordinating activity of neurons that code related information (Jensen Lisman, 2005). Here, a hippocampal-dependent, object–place association task (Clark 2000; Broadbent 2004; Eacott Norman, Lee 2005; Winters 2008; Barker Warburton, 2011) was used in rats to investigate how slow fast the hippocampus...
Abstract Theta rhythms temporally coordinate sequences of hippocampal place cell ensembles during active behaviors, while sharp wave-ripples rest. We investigated whether such coordination is disrupted error trials in a delayed match-to-place task. As reward location was learned across trials, developed that represented compressed paths to the approach location. Less were on as an incorrect stop approached. During rest periods correct but not bias replay representations ending at These...
The theta-gamma cross-frequency coupling (CFC) in hippocampus was reported to reflect memory process. In this study, we measured the CFC of hippocampal local field potentials (LFPs) a two-vessel occlusion (2VO) rat model, combined with both amplitude and phase properties associated short long-term plasticity indicating function. Male Wistar rats were used 2VO model established. STP LTP recorded CA3-CA1 pathway after LFPs collected CA3 CA1. Based on data relative power spectra...
The experience-dependent spatial cognitive process requires sequential organization of hippocampal neural activities by theta rhythm, which develops to represent highly compressed information for rapid learning. However, how the sequences were developed in a finer time scale within cycles remains unclear. In this study, we found that sweep-ahead structure developing with exploration was predominantly dependent on relatively large proportion FG-cells, i.e. subset place cells dominantly...
The experience-dependent spatial cognitive process requires sequential organization of hippocampal neural activities by theta rhythm, which develops to represent highly compressed information for rapid learning. However, how the sequences were developed in a finer timescale within cycles remains unclear. In this study, we found rats that sweep-ahead structure developing with exploration was predominantly dependent on relatively large proportion FG-cells, is subset place cells dominantly...
Abstract It is of great social significance and clinical value to explore new effective treatments for depression. Low-intensity focused ultrasound stimulation (LIFUS) has been indicated have notable neuroprotective effects on However, little known about how different strategies LIFUS affect the therapeutic effect. Therefore, purpose this study investigate whether depression-like behaviors are associated with intensity underlying mechanisms. We established depression rats model using chronic...
Depression is one of the most serious mental disorders affecting modern human life and often caused by chronic stress. Dopamine system dysfunction proposed to contribute pathophysiology stress, especially ventral tegmental area (VTA) which mainly consists dopaminergic neurons. Focused ultrasound stimulation (FUS) a promising neuromodulation modality multiple studies have demonstrated effective ultrasonic activation cortical, subcortical, related networks. However, effects FUS on dopamine...
Elderly hypertensive patients diagnosed with transient ischemic attack (TIA) are at a heightened risk for developing acute stroke (AIS). This underscores the critical need effective prediction and identification of predictive factors. In our study, we utilized patient data from peripheral blood tests clinical profiles within hospital information systems. These were followed three-year period to document incident AIS. Our cohort 11,056 individuals was randomly divided into training,...
In hippocampal area CA1, slow (∼25-55 Hz) and fast (∼60-100 gamma rhythms are coupled with different CA1 afferents. is to inputs from CA3, the medial entorhinal cortex (Colgin LL, Denninger T, Fyhn M, Hafting Bonnevie Jensen O, Moser MB, EI. Nature 462: 353-357, 2009). CA3 gives rise highly divergent associational projections, it possible that reverberating activity in these connections generates hippocampus. However, maximal upstream of dentate gyrus (DG) region (Bragin A, Jando G, Nadasdy...
Working memory impairment is one of the remarkable cognitive dysfunctions induced by vascular dementia (VD), and it necessary to explore an effective treatment. Recently, low-intensity focused ultrasound stimulation (LIFUS) has been found notable neuroprotective effects on some neurological diseases, including VD. However, whether could ameliorate VD-induced working was still not clarified. The purpose this study address issue underlying mechanism. We established VD rat model using bilateral...
The excitatory neurons of the medial prefrontal cortex (mPFC) respond to social stimuli. However, little is known about how neural activity altered during avoidance, and whether it could act as a target low-intensity focused ultrasound stimulation (LIFUS) rescue deficits. present study aimed investigate mechanisms neuronal activities inflammatory responses underlying effect LIFUS on avoidance. We found that chronic can effectively improve avoidance in defeated mice. Calcium imaging...