A5065058935- Pharmacological Effects of Natural Compounds
- RNA modifications and cancer
- Computational Drug Discovery Methods
- Gut microbiota and health
- Circular RNAs in diseases
- Inflammatory Bowel Disease
- Flavonoids in Medical Research
- Cancer-related molecular mechanisms research
Jining Medical University
2021-2024
Paeoniflorin (PF) is the primary component derived from <em>Paeonia lactiflora</em> and white peony root has been used widely for treatment of ulcerative colitis (UC) in China. UC primarily manifests as a chronic inflammatory response intestine. In present study, network pharmacology approach was to explore specific effects underlying mechanisms action PF UC. A research strategy based on pharmacology, combining target prediction, construction, Gene Ontology (GO), Kyoto Encyclopedia Genes...
This study aims to analyze the targets of effective active ingredients Scutellariae radix-Coptidis rhizoma drug pair (SCDP) in ulcerative colitis (UC) by network pharmacology and molecular docking explore associated therapeutic mechanism. The SCDP were determined from TCMSP database, ingredient-target was constructed using Cytoscape software. disease related UC searched GeneCards, DisGeNET, OMIM, DrugBank databases. Then, ingredient intersected construct a protein-protein interaction through...
Background Ulcerative colitis (UC) is a common chronic disease associated with inflammation and oxidative stress. This study aimed to construct long noncoding RNA (lncRNA)-microRNA (miRNA)-messenger (mRNA) network based on bioinformatics analysis explore stress-related genes underlying the pathogenesis of UC. Methods The GSE75214 , GSE48959 GSE114603 datasets were downloaded from Gene Expression Omnibus database. Following differentially expressed (DE) analysis, regulatory relationships...