A5101485877- Metabolism, Diabetes, and Cancer
- Yersinia bacterium, plague, ectoparasites research
- Pharmacological Effects of Natural Compounds
- Protein Structure and Dynamics
- Retinoids in leukemia and cellular processes
- Bacillus and Francisella bacterial research
- Biochemical Acid Research Studies
- Paraoxonase enzyme and polymorphisms
- Diabetes Treatment and Management
- Bone and Joint Diseases
- Adipose Tissue and Metabolism
- Estrogen and related hormone effects
- Pancreatic function and diabetes
- Pregnancy and preeclampsia studies
- Inflammatory mediators and NSAID effects
- Listeria monocytogenes in Food Safety
- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Plant-based Medicinal Research
- Coenzyme Q10 studies and effects
First Affiliated Hospital of Fujian Medical University
2019
Fujian Medical University
2019
Southern Illinois University School of Medicine
2010
United States Department of the Army
2010
Telemedicine & Advanced Technology Research Center
2008
United States Army Medical Research and Development Command
2008
Rockefeller University
2007
Human paraoxonase (HuPON1) is a serum enzyme that exhibits broad spectrum of hydrolytic activities, including the hydrolysis various organophosphates, esters, and recently identified lactone substrates. Despite intensive site-directed mutagenesis other biological studies, structural basis for specificity substrate interactions HuPON1 remains elusive. In this study, we apply homology modeling, docking, molecular dynamic (MD) simulations to probe binding with representative The results suggest...
Yersinia spp. is currently an antibiotic resistance concern and a re-emerging disease. The essential virulence factor protein kinase A (YpkA) contains Ser/Thr domain whose activity modulates pathogenicity. Here, we present approach integrating machine learning method, homology modeling, multiple conformational high-throughput docking for the discovery of YpkA inhibitors. These first reported inhibitors may facilitate studies pathogenic mechanism serve as starting point development anti-plague drugs.
Metformin, a widely used antidiabetic drug, has been shown to have anti-inflammatory properties; nevertheless, its influence on β-cell meta-inflammation remains unclear. The following study investigated the effects of metformin meta-inflammatory in β-cells and whether underlying mechanisms were associated with G protein-coupled receptor 40-phospholipase C-inositol 1, 4, 5-trisphosphate (GPR40-PLC-IP3) pathway. Lipotoxicity-induced high-fat diet-induced obese rat model study....
Knowledge of the three-dimensional (3D) structures protein complexes provides a fundamental understanding biological systems, as well novel insights for antimicrobial drug and vaccine design. Protein-protein docking is used to predict 3D from their components in silico. In this study, we developed protein-protein pipeline (PPDP) that integrates variety state-of-the-art structure prediction techniques, providing systematic platform large-scale interactions (PPIs). The PPDP deployed on high...