A5059077667- Pregnancy and preeclampsia studies
- Reproductive System and Pregnancy
- Angiogenesis and VEGF in Cancer
- Transplantation: Methods and Outcomes
- Neonatal Respiratory Health Research
- Blood Coagulation and Thrombosis Mechanisms
- Congenital heart defects research
- Cardiovascular Disease and Adiposity
- Renal Diseases and Glomerulopathies
- Maternal and fetal healthcare
- Mechanical Circulatory Support Devices
- Birth, Development, and Health
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Systemic Lupus Erythematosus Research
- Cardiac and Coronary Surgery Techniques
- Renal Transplantation Outcomes and Treatments
- Pharmaceutical Practices and Patient Outcomes
- Blood Pressure and Hypertension Studies
- Viral Infections and Immunology Research
- Resilience and Mental Health
- Platelet Disorders and Treatments
- Mindfulness and Compassion Interventions
- Pulmonary Hypertension Research and Treatments
- Fibroblast Growth Factor Research
Drake University
2010-2025
Southern Illinois University School of Medicine
2003-2012
Indiana University Health
1998-2001
HealthPartners
2001
National Taiwan University
2001
Houston Methodist
1997-2000
Methodist Hospital
1996-2000
IST Research
1998-1999
Cleveland Clinic
1998
Indiana University School of Medicine
1998
Placenta growth factor (PlGF), a member of the vascular endothelial family angiogenic factors, is prominently expressed by trophoblast. In addition to its role as paracrine within placenta and endometrium, presence receptor, Flt-1, on trophoblast suggests that PlGF also may have an autocrine role(s) in regulating function. To elucidate trophoblast, we examined signal transduction functional responses primary human PlGF. Exogenous induced specific activation stress-activated protein kinase...
Placental growth factor (PGF, previously known as PlGF) is prominently expressed by trophoblasts in human placenta, whereas most nontrophoblast cells express low levels of PGF mRNA under normal physiological conditions. We have shown that hypoxia decreases expression the trophoblast, but little about transcriptional regulation gene expression. sought to determine promoter regions contribute its restricted high constitutive trophoblast. Overlapping putative encompassing 2-1.5 kb were cloned...
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Vascular endothelial growth factor (VEGF) is an cell-specific mitogen thought to play important role in coronary collateral vessel formation. We used immunocytochemistry determine VEGF expression biopsies (n = 283) of transplanted human hearts 109) with and without microvascular fibrin. Measures vascular fibrin, alpha 2 plasmin-inhibitor (a2Pl), macrophages, neutrophils, serum cardiac troponin T titers were evaluate myocardial damage. Antibody lymphocytes was cellular rejection, HLA-DR,...
Abstract Vascular endothelial growth factor (VEGF) and basic fibroblast (bFGF) stimulate cell proliferation, migration, vascular tube formation. We tested the hypotheses that these factors (1) migration (2) assembly into cord‐like structures in embryonic rat heart explants cultured on collagen gels. Atrial ventricular from embryos at 12 (E12, avascular) 14 (E14, early vascularization stage) days of gestation were a substrate. Western blot analysis indicated endogenous VEGF was present both...
Volume overload-induced cardiac hypertrophy is characterized by normal coronary reserve and maximal flow. Accordingly, we tested the hypothesis that both arteriolar capillary growth are proportional to magnitude of in this model. Five months after performing an aortocaval fistula [arteriovenous (A-V) shunt] young rats, right left ventricles were 61 55%, respectively, heavier than their sham controls. Using morphometric methods image analysis, found increases myocyte cross-sectional area...