A5037091749- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Cell Adhesion Molecules Research
- 3D IC and TSV technologies
- Cardiovascular Disease and Adiposity
- Eosinophilic Esophagitis
- Neonatal Respiratory Health Research
- Virus-based gene therapy research
- Viral gastroenteritis research and epidemiology
- Cancer-related molecular mechanisms research
- Cancer Cells and Metastasis
- MicroRNA in disease regulation
- Immune cells in cancer
- Selenium in Biological Systems
- Wnt/β-catenin signaling in development and cancer
- Respiratory viral infections research
- Fibroblast Growth Factor Research
- Neuropeptides and Animal Physiology
- Hedgehog Signaling Pathway Studies
- Hydrogen's biological and therapeutic effects
- Radiomics and Machine Learning in Medical Imaging
- Genetic factors in colorectal cancer
- Extracellular vesicles in disease
- Nanofabrication and Lithography Techniques
- Dental Trauma and Treatments
Vanderbilt University
1993-2023
Vanderbilt University Medical Center
2016-2023
Tripler Army Medical Center
2021
Johns Hopkins University
2015-2016
Johns Hopkins Medicine
2015-2016
University of Colorado Denver
2013-2015
University of Colorado Anschutz Medical Campus
2013-2015
University of North Carolina at Chapel Hill
2014
University of Aberdeen
2014
Draper Laboratory
2010-2011
In a prospective double-blind trial, the reactogenicity and immunogenicity of recombinant baculovirus influenza A vaccines containing purified full-length hemagglutinin (HA) were compared with standard trivalent inactivated vaccine (TIY). The (THAO)were monovalent (containing 45 µg A/Beijing/92[H3] 15,45, 135 A/Texas/ 91[H1)) bivalent both A/Beijing/92 A/Texas/91). rHAO produced fewer local side effects than TIY (50% vs. 88%, P = .003). inhibition (HAl) responses (defined as ⩾4 increase in...
Although selenium deficiency correlates with colorectal cancer (CRC) risk, the roles of selenium-rich antioxidant selenoprotein P (SELENOP) in CRC remain unclear. In this study, we defined SELENOP's contributions to sporadic CRC. human single-cell cRNA-Seq (scRNA-Seq) data sets, discovered that SELENOP expression rose as normal colon stem cells transformed into adenomas progressed carcinomas. We next examined effects Selenop KO a mouse adenoma model involved conditional, intestinal...
Lung M2 macrophages are regulators of airway inflammation, associated with poor lung function in allergic asthma. Previously, we demonstrated that IL-4-induced gene expression correlated tyrosine phosphorylation the insulin receptor substrate-2 (IRS-2) macrophages. We hypothesized negative regulation IRS-2 activity after IL-4 stimulation is dependent upon serine IRS-2. Herein, describe an inverse relationship between (Tyr(P)) and (Ser(P)) stimulation. Inhibiting phosphatase increased...
Blood vessel epicardial substance (BVES/Popdc1) is a junctional-associated transmembrane protein that underexpressed in number of malignancies and regulates epithelial-to-mesenchymal transition. We previously identified role for BVES regulation the Wnt pathway, modulator intestinal stem cell programs, but its small (SI) biology remains unexplored. hypothesized influences programs critical to SI homeostasis after radiation injury. At baseline, Bves(-/-) mice demonstrated increased crypt...
Abstract Lung adenocarcinoma (AdC) and lung squamous cell carcinoma (SCC) are the most common non‐small cancer (NSCLC) subtypes, however, genetic mouse models of produce predominantly, if not exclusively, AdC. Whether this is secondary to targeting mutations distal airway cells or use activating Kras that drive AdC formation unknown. We previously showed G12D activation transforming growth factor β receptor type II (TGFβRII) deletion basal via a keratin promoter induced both SCC. In study we...
Serine threonine kinase 17A (STK17A) is a ubiquitously expressed originally identified as regulator of apoptosis; however, whether it functionally contributes to colorectal cancer has not been established. Here, we have analyzed STK17A in and demonstrated decreased expression primary tumors, which further reduced metastatic lesions, indicating potential role regulating the cascade. Interestingly, changes did modify proliferation, apoptosis, or sensitivity cell lines treatment with...
Blood vessel epicardial substance (BVES, otherwise known as POPDC1) is an integral membrane protein to regulate tight junction formation and epithelial-mesenchymal transition. BVES underexpressed in a number of malignancies, including colorectal cancer. loss leads activation the Wnt pathway, suggesting that decreased expression functionally contributes tumorigenesis. However, mechanism by which modulates signaling unknown. Here, we confirm increases β-catenin levels, pathway...
MTG16 is a member of the myeloid translocation gene (MTG) family transcriptional corepressors. While MTGs were originally identified in chromosomal translocations acute leukemia, recent studies have uncovered role intestinal biology. For example, Mtg16-/- mice increased proliferation and are more sensitive to injury colitis models. also underexpressed patients with moderate/severe ulcerative colitis. Based on these findings, we postulated that might protect against colitis-associated...
We examine the thermomechanical tradeoffs in a novel technology for high density interconnect (HDI) substrates. Fabricated from silicon (Si) wafers with planar cavities of highly-filled composite encapsulant, leverages established Si photolithography but offers improved mechanical properties. Modules are subject to stress during encapsulant cure, assembly reflow, module fabrication, and operation. show that improvements junction-to-ambient sinking offset heat increase such systems low...
We outline several approaches to allow individual die be encapsulated within a silicon substrate, which we define as cavity wafer, without causing wafer bow. This technique forms the basis for novel integrated ultra high density (i-UHD) wafer-level packaging platform. The iUHD process begins with standard Si that is patterned and dry etched form cavities accept buried components. After etching, blanket metalized. Individual commercial off-the-shelf (COTS) are placed onto an adhesive film...
Abstract Synovial sarcoma is a rare soft tissue which frequently involves the upper or lower extremities. Soft sarcomas including synovial have propensity to metastasize lungs, and there are very few reports of metastatic lesions in other locations. Here, we report case 49-year-old patient who underwent neoadjuvant chemoradiation for an extremity presented approximately 4 years later with abdominal pain hemoperitoneum was ultimately found involving greater curvature stomach surrounding...
Rotavirus vaccine strains representing serotypes 1 and 2 have been derived by reassortment between genes of a rhesus rotavirus master strain, MMU18006, the gene from human viruses coding for VP7, surface protein with neutralizing determinants. As simultaneous administration these two reassortants had resulted in disappointing strain-specific immunity, vaccines were administered sequentially to infants young children assess whether immunity both could be achieved monovalent doses. Following...
Abstract Allergic asthma is characterized by acute inflammation of the airways with alternatively activated (M2) macrophages as key regulators disease severity. Robust, yet transient tyrosine phosphorylation (pY) IRS-2 in response to IL-4 leads enhanced M2 gene activation. Mechanisms for downregulation IL-4-induced signaling have not been determined although serine (pS) IRS proteins terminates insulin-activated signaling. We hypothesize that plays a role inhibiting responses. Human monocytic...