A5091168899- Cervical Cancer and HPV Research
- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Global Cancer Incidence and Screening
- COVID-19 and healthcare impacts
- Endometriosis Research and Treatment
- Colorectal Cancer Screening and Detection
- Cardiac, Anesthesia and Surgical Outcomes
- Clinical practice guidelines implementation
- Reproductive tract infections research
- Preterm Birth and Chorioamnionitis
- Genital Health and Disease
- Pregnancy and preeclampsia studies
- Trauma and Emergency Care Studies
- Uterine Myomas and Treatments
- Colorectal Cancer Surgical Treatments
- Intraperitoneal and Appendiceal Malignancies
- Cancer survivorship and care
- Child and Adolescent Health
- Cancer Risks and Factors
- Urological Disorders and Treatments
- Neonatal Respiratory Health Research
- BRCA gene mutations in cancer
- Birth, Development, and Health
- Ectopic Pregnancy Diagnosis and Management
Betsi Cadwaladr University Health Board
2014-2023
Laboratoire des Sciences de l'Ingénieur, de l'Informatique et de l'Imagerie
2020-2022
Ysbyty Gwynedd Hospital NHS Trust
2002-2021
University of Birmingham
2020-2021
Institut de Virologie
2021
Belfast City Hospital
2016-2021
NIHR Birmingham Biomedical Research Centre
2021
Yorkshire Cancer Research
2021
Urology Foundation
2021
Association for Cancer Surgery
2021
Ovarian cancer has a poor prognosis, with just 40% of patients surviving 5 years. We designed this trial to establish the effect early detection by screening on ovarian mortality.
Ovarian cancer has a high case-fatality ratio, with most women not diagnosed until the disease is in its advanced stages. The United Kingdom Collaborative Trial of Cancer Screening (UKCTOCS) randomised controlled trial designed to assess effect screening on mortality. This report summarises outcome prevalence (initial) screen UKCTOCS.Between 2001 and 2005, total 202 638 post-menopausal aged 50-74 years were randomly assigned no treatment (control; n=101 359); annual CA125 (interpreted using...
BackgroundOvarian cancer continues to have a poor prognosis with the majority of women diagnosed advanced disease. Therefore, we undertook UK Collaborative Trial Ovarian Cancer Screening (UKCTOCS) determine if population screening can reduce deaths due We report on ovarian mortality after long-term follow-up in UKCTOCS.MethodsIn this randomised controlled trial, postmenopausal aged 50–74 years were recruited from 13 centres National Health Service trusts England, Wales, and Northern Ireland....
Purpose Cancer screening strategies have commonly adopted single-biomarker thresholds to identify abnormality. We investigated the impact of serial biomarker change interpreted through a risk algorithm on cancer detection rates. Patients and Methods In United Kingdom Collaborative Trial Ovarian Screening, 46,237 women, age 50 years or older underwent incidence by using multimodal strategy (MMS) in which annual serum antigen 125 (CA-125) was with ovarian (ROCA). Women were triaged ROCA:...
The increase in the worldwide incidence of endometrial cancer relates to rising obesity, falling fertility, and ageing population. Transvaginal ultrasound (TVS) is a possible screening test, but there have been no large-scale studies. We report performance TVS large cohort.We did nested case-control study postmenopausal women who underwent United Kingdom Collaborative Trial Ovarian Cancer Screening (UKCTOCS) following recruitment between April 17, 2001, Sept 29, 2005. Endometrial thickness...
Objective To describe the factors that contributed to successful recruitment of more than 200 000 women UK Collaborative Trial Ovarian Cancer Screening, one largest ever randomised controlled trials. Design Descriptive study. Setting 13 NHS trusts in England, Wales, and Northern Ireland. Participants Postmenopausal aged 50-74; exclusion criteria included ovarian malignancy, bilateral oophorectomy, increased risk familial cancer, active non-ovarian participation other cancer screening Main...
Abstract Objective To estimate the risk of primary epithelial ovarian cancer (EOC) and slow growing borderline or Type I aggressive II EOC in postmenopausal women with adnexal abnormalities on ultrasound. Methods This was a prospective cohort study ultrasound group UK Collaborative Trial Ovarian Cancer Screening ultrasound‐detected abnormal (unilocular, multilocular, unilocular solid multilocular solid, solid) morphology their first scan. Women were followed up through national registries by...
There are limited data on surgical outcomes in gynaecological oncology. We report predictors of complications a multicentre prospective study. Data procedures and resulting were contemporaneously recorded consented patients 10 participating UK cancer centres. Patients sent follow-up letters to capture any further complications. Post-operative (Post-op) graded (I–V) increasing severity using the Clavien-Dindo system. Grade I excluded from analysis. Univariable multivariable regression was...
(Abstracted from Lancet 2021;397:2182–2193) Ovarian cancer is most commonly diagnosed at an advanced stage (3 or 4) and remains the deadliest gynecologic malignancy. When 1, a survival rate of greater than 90% has been demonstrated, compared with 5-year 27% 13% for 3 4 disease, respectively.
Abstract Background Participants in trials evaluating preventive interventions such as screening are on average healthier than the general population. To decrease this 'healthy volunteer effect' (HVE) women were randomly invited from population registers to participate United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) and not allowed self refer. This report assesses extent HVE still prevalent UKCTOCS considers how certain shortfalls mortality incidence can be related...
The commencing age of cervical screening in England was raised from 20 to 25 years 2004. Cervical cancer incidence young women is increasing. It not clear if this due either greater exposure population risk factors or reduced screening. We measured the relative younger (20–29 years) north-east (NE) differed that aged 30yrs and above since also average annual percentage change (AAPC) 3 yr moving for all age-groups. Regional coverage rate were reviewed. Comparisons made with Wales where...
Objective To establish a baseline of national practice for follow-up after treatment gynaecological cancer. Design Questionnaire survey. Setting Gynaecological cancer centres and units. Geographical location UK. Participants Members the British Cancer Society National Forum Oncology Nurses. Interventions A questionnaire Outcome measures determine schedules follow-up, who provides it what routine testing is used patients have had previous Results total 117 responses were obtained; 115 (98%)...
To investigate quality of life (QoL) and association with surgical complexity disease burden after resection for advanced ovarian cancer in centres variation approach.Prospective multicentre observational study.Gynaecological surgery the UK, Kolkata, India, Melbourne, Australia.Patients undergoing (with low, intermediate or high score, SCS) late-stage cancer.Primary: change global score on European Organisation Research Treatment Cancer (EORTC) core quality-of-life questionnaire (QLQ-C30)....
To assess the within-trial cost-effectiveness of an NHS ovarian cancer screening (OCS) programme using data from UKCTOCS and extrapolate results based on average life expectancy.Within-trial economic evaluation no (C) vs either (1) annual OCS transvaginal ultrasound (USS) or (2) multimodal with serum CA125 interpreted a risk algorithm (ROCA) as second-line test (MMS), plus comparison lifetime extrapolation arm MMS both predictive Markov model.Using CA125-ROCA cost £20, show USS to be...
The study was designed to determine whether fetal fibronectin would predict delivery before 37 weeks in women at high risk of preterm delivery.Forty-three considered were recruited antenatally into a blind longitudinal study. Quantitative assays obtained from sequential vaginal swabs taken fortnightly 24 34 gestation. Fibronectin concentrations 0.05 microgram/ml or more as positive.Results calculated by swab and subject. sensitivity an individual predicting within 14 days testing 71% the...
<h3>Objective</h3> This study aimed to evaluate the feasibility of completing a parallel-group randomized controlled trial compare usual follow-up care for women who have completed treatment gynecological cancer against nurse-led telephone intervention, known as Optimal Personalised Care After Treatment—Gynaecological. <h3>Methods</h3> The unblinded recruit patients had cervical, endometrial, epithelial ovarian, or vulval within previous 3 months at North Wales hospitals. We participants...
We investigated URS and impact on survival in whole patient cohorts with AOC treated within gynaecological cancer centres that participated the previously presented SOCQER 2 study. National registry datasets were used to identify FIGO Stage 3,4 unknown stage patients from 11 had SOCQER2 Patient outcomes’ association surgical ethos evaluated using logistic regression Cox proportional hazards. Centres classified into three groups based their complexity scores (SCS); those practicing mainly low...