A5050760305- Ovarian cancer diagnosis and treatment
- Pregnancy and preeclampsia studies
- Ovarian function and disorders
- Reproductive Biology and Fertility
- Prenatal Screening and Diagnostics
- Assisted Reproductive Technology and Twin Pregnancy
- Endometriosis Research and Treatment
- Fetal and Pediatric Neurological Disorders
- Ectopic Pregnancy Diagnosis and Management
- Birth, Development, and Health
- Congenital Diaphragmatic Hernia Studies
- Congenital Anomalies and Fetal Surgery
- BRCA gene mutations in cancer
- Maternal and fetal healthcare
- Endometrial and Cervical Cancer Treatments
- Neonatal Respiratory Health Research
- Neonatal and fetal brain pathology
- Gestational Diabetes Research and Management
- Gynecological conditions and treatments
- Cleft Lip and Palate Research
- Ultrasound and Hyperthermia Applications
- Genetic factors in colorectal cancer
- Tracheal and airway disorders
- Congenital Heart Disease Studies
- Maternal and Perinatal Health Interventions
CREATe Centre
2021
University of Edinburgh
2020
CReATe Fertility Centre
2019
Hôpital Saint-Michel
2017
University of London
1993-2016
St George's Hospital
1997-2016
University College London
1992-2015
Royal London Hospital
1996-2015
St Bartholomew's Hospital
2015
Create (Sweden)
2014
Ovarian cancer has a high case-fatality ratio, with most women not diagnosed until the disease is in its advanced stages. The United Kingdom Collaborative Trial of Cancer Screening (UKCTOCS) randomised controlled trial designed to assess effect screening on mortality. This report summarises outcome prevalence (initial) screen UKCTOCS.Between 2001 and 2005, total 202 638 post-menopausal aged 50-74 years were randomly assigned no treatment (control; n=101 359); annual CA125 (interpreted using...
Purpose Cancer screening strategies have commonly adopted single-biomarker thresholds to identify abnormality. We investigated the impact of serial biomarker change interpreted through a risk algorithm on cancer detection rates. Patients and Methods In United Kingdom Collaborative Trial Ovarian Screening, 46,237 women, age 50 years or older underwent incidence by using multimodal strategy (MMS) in which annual serum antigen 125 (CA-125) was with ovarian (ROCA). Women were triaged ROCA:...
OBJECTIVE--To assess whether changes in the intraovarian vasculature or blood flow impedance can be used to identify potentially malignant masses. DESIGN--Open, non-comparative prospective study. SETTING--Ovarian screening clinics at King9s College Hospital and Hallam Medical Centre. SUBJECTS--50 Women selected on basis of their medical history result a previous transvaginal ultrasound scan. Thirty women (10 premenopausal (scan taken days 1 8 menstrual cycle) 20 postmenopausal) had normal...
To assess the value of ultrasonography in a screening procedure for early ovarian cancer.Prospective study at least 5000 self referred women without symptoms cancer. Each woman was scheduled to undergo three annual screenings (consisting one or more scans) detect grossly abnormal ovaries non-regressing masses.The clinic King's College Hospital, London.5479 Self (aged 18-78, mean age 52).Women with positive result on were laparoscopy laparotomy, both.Findings surgery and from histology...
To assess the value of transvaginal ultrasonography with colour blood flow imaging in detecting early ovarian cancer women a family history disease.Study self referred symptomless close relative who had developed disease. Each woman was screened to detect persistent lesions and defined changes volume. Morphological score pulsatility index were recorded.Ovarian screening clinic.1601 women.Women positive result recommended have further investigations.Findings at surgery histology abnormal...
ABSTRACT Objective To assess the value of incorporating continuous wave Doppler ultrasound uterine arteries into routine scan as a screening test in an unselected population. Design A cross sectional study by multiple operators using to obtain flow velocity waveforms (FVW) from both all women attending for anomaly at 18 22 weeks over period 12 months. An abnormal FVW either artery was used predict intrauterine death, antepartum haemorrhage and three different degrees severity preeclampsia...
A total of 96 women undergoing in vitro fertilization (IVF) treatment were studied on the day human chorionic gonadotropin (hCG) administration by transvaginal ultrasonography with color and pulsed Doppler ultrasound. We assessed endometrial thickness, morphology, presence or absence subendometrial intraendometrial flow, vascular penetration blood flow velocimetry hCG related results to pregnancy rates. The overall rate was 32.3% (31/96) there no significant difference between pregnant...
Abstract Objective To assess the clinical value of a novel three‐dimensional (3D) ultrasound technique, reverse face view (3D RF view), in antenatal categorization facial clefting and particular hard palate. Methods Eight cases suspected orofacial were examined by 3D surface rendering. The fetal lips alveolar ridge frontal plane was then rotated through 180° on vertical axis to examine secondary palate view. Results In each case described, we able visualize face, make an diagnosis as whether...
A technique for fetal blood-sampling in the second trimester of pregnancy (between 16 and 22 weeks9 gestation) combining fetoscopy with real-time ultrasound was used 48 attempts at blood-sampling. Specimens containing red cells or without amniotic fluid maternal blood, adequate diagnosing haemoglobinopathies, were obtained 45 fetoscopies. Sampling successful all 18 patients a posterior placenta, 27 30 an anterior placenta. In last consecutive fetoscopies pure blood taken; placenta six. Out...
Blood flow changes in the ovarian stroma of women embarking on in-vitro fertilization treatment were assessed day 2 or 3 menstrual cycle using colour and pulsed Doppler ultrasound. Women divided into three groups: group 1, 63 with regular, ovulatory cycles normal ovaries ultrasound scan; 2, 13 similar to 1 but polycystic (PCO) 3, 12 biochemical evidence previous anovulatory and/or oligomenorrhoea elevated serum luteinizing hormone concentrations (> 10 IU/l) early follicular phase together...
To evaluate the predictive value of transvaginal Doppler ultrasound studies uterine and umbilical arteries in early pregnancy, identifying pregnant women at risk subsequently developing pre-eclampsia, or delivery a small for gestational age infant.A multivariate logistic regression Z scores indices obtained from 652 with singleton pregnancies 12 to 16 weeks gestation. Measurements included presence absence notch, bilateral (right left waveform) notching, vessel diameter, resistance index,...
At the present time, pathogenesis of ovarian cancer remains poorly understood, with invasive diagnosis and ineffective treatment for women disease. Despite scientific medical advances in oncology, overall 5-year survival rate 30% patients has not changed 20 years. An understanding angiogenic process as it occurs would only increase our knowledge this but also might offer novel opportunities therapeutic intervention.Our aim was to study expression messenger RNA (mRNA) coding four putative...
The short-term psychological effects on the mother of real-time ultrasound examination early in pregnancy have been evaluated. Primiparae were randomly assigned to one two groups: a high feedback, where they saw monitor screen; b low scan was accompanied by global evaluation progress. Women assessed before and after examination. results confirm acceptability scanning, with mothers both groups displaying more positive attitudes it. Significant between-group differences emerged respect...