A5085063339- Cervical Cancer and HPV Research
- Global Cancer Incidence and Screening
- Genital Health and Disease
- Reproductive tract infections research
- Endometrial and Cervical Cancer Treatments
- Holomorphic and Operator Theory
- Algebraic and Geometric Analysis
- Hepatitis B Virus Studies
- Colorectal Cancer Screening and Detection
- Advanced Harmonic Analysis Research
- Meromorphic and Entire Functions
- Urinary Tract Infections Management
- Advanced Topics in Algebra
- Pelvic floor disorders treatments
- Advanced Banach Space Theory
- Reproductive System and Pregnancy
- dental development and anomalies
- Preterm Birth and Chorioamnionitis
- Immunotherapy and Immune Responses
- Molecular Biology Techniques and Applications
- Genetic Associations and Epidemiology
- Analytic and geometric function theory
- Infectious Diseases and Mycology
- Research in Social Sciences
- Prenatal Screening and Diagnostics
Helsinki University Hospital
2015-2024
University of Helsinki
2015-2024
Hospital District of Helsinki and Uusimaa
2020-2024
Weatherford College
2021
Helsinki Art Museum
2017-2021
University of Turku
2017-2020
Åbo Akademi University
2020
University of Missouri–Kansas City
2019
Antwerp University Hospital
2019
Montefiore Medical Center
2019
Human papillomavirus (HPV) DNA testing has shown higher sensitivity than cytology for detecting cervical lesions, but it is uncertain whether the dependent on age of woman being screened. We compared age-specific performance primary HPV screening with that conventional in setting an organized population-based cancer program Finland.From January 1, 2003, to December 31, 2005, randomized invitations were sent women aged 25-65 years routine by high-risk (n = 54 207) a Hybrid Capture 2 assay...
To describe the efficacy of Finnish mass screening program for cervical squamous carcinoma and adenocarcinoma, as reflected by changes incidence mortality rate. Cervical cancer data were obtained from Cancer Registry. Data available year 1953, when registry was established. The nationwide in Finland started mid-1960s. A centralized organization administers this program. Women age 30–60 years are notified every 5 years. mean early 1960s 15.4 per 105 woman-years. In 1991, it only 2.7 rate has...
The current paper presents the first part of Chapter 6 second edition European Guidelines for Quality Assurance in Cervical Cancer Screening . It provides guidance on how to manage women with abnormal cervical cytology. Throughout this article Bethesda system is used cytology terminology, as guidelines have recommended that all systems should at least be translated into terminology while intraepithelial neoplasia (CIN) histological biopsies ( Cytopathology 2007; 18 :213–9). A woman a...
The current paper presents the second part of chapter 6 edition European Guidelines for Quality Assurance in Cervical Cancer Screening. first same was published a previous issue (Cytopathology 2008;19:342-54). This provides guidance on how to manage and treat women with histologically confirmed cervical intraepithelial neoplasia. describes characteristics, indications possible complications excisional ablative treatment methods. three options monitor outcome after (repeat cytology, HPV...
Attendance in screening is an important determinant of cervical cancer. Previous experience on high-risk human papillomavirus (hrHPV) DNA testing patient-obtained samples suggests a good effect among nonattendees screening. We assessed the effects self-sampling attendance Finnish program.Nonattendees after primary invitation one municipality (Espoo) were randomized to receive either kit (2,397 women) or extra (6,302 women). One fourth (1,315 reminder letter arm also received as third...
Failure to develop complete dentition, tooth agenesis, is a common developmental anomaly manifested most often as isolated but also associated with many syndromes. It typically affects third molars or one few other permanent teeth severe agenesis relatively prevalent. Here we report mutational analyses of seven candidate genes in cohort 127 probands non-syndromic agenesis. 82 lacked more than five excluding molars, called oligodontia. We identified 28 mutations, 17 which were novel. Together...
Abstract The age‐standardised incidence of cervical cancer in Europe varies widely by country (between 3 and 25/100000 women‐years) 2018. Human papillomavirus (HPV) vaccine coverage is low countries with the highest screening performance heterogeneous among European countries. A broad group delegates scientific professional societies organisations endorse principles WHO call to eliminate as a public health problem, also Europe. All nations should, 2030, reach at least 90% HPV girls age 15...
A nation-wide screening programme for cervical cancer started in Finland gradually from 1963 onwards. By the beginning of 1990s, there had been a decrease 80% both age-adjusted incidence and mortality cancer. To describe recent patterns evaluate their differentials relation with organised activities, we have updated material on as well mass-screening activities up to year 1995. Based files Finnish Cancer Registry, is striking increase about 60% during last 4 years study period among women...
To compare the effect of organised pap-smear screening for cervical cancer with that spontaneous one on incidence invasive cancer, we performed a case-control study within catchment area Helsinki University Hospital (Helsinki, Finland). The material consisted 179 incident cases and 1,507 population controls. Data lifetime pap smears before year diagnosis were collected using self-administered questionnaire. questionnaire information was obtained 82% 73% main outcome measure relative risk...
<h3>Abstract</h3> <b>Objective</b> To study the long term risk of cervical and other cancers after treatment for intraepithelial neoplasia. <b>Design</b> Retrospective cohort study. <b>Setting</b> University Hospital, Helsinki, Finland. <b>Participants</b> 7564 women treated neoplasia during 1974 2001 followed up through Finnish cancer registry until 2003. <b>Main outcome measures</b> Standardised incidence ratio cancers. <b>Results</b> During follow-up 22 cases invasive occurred in...
The current paper presents an annex in the second edition of European Guidelines for Quality Assurance Cervical Cancer Screening. It provides guidance on how to make a satisfactory conventional Pap smear or liquid‐based cytology (LBC) sample. Practitioners taking samples should first explain woman purpose, procedure and result will be communicated. Three sampling methods are considered as acceptable preparing smears: (i) cervical broom; (ii) combination spatula endocervical brush; (iii)...
<h3>ABSTRACT</h3> <i>Nippostrongylus brasiliensis</i> is a well-defined model of type-2 immunity but the early lung-migrating phase dominated by innate IL-17A production and neutrophilia. Using <i>N. infection we confirm previous observations that <i>Il17a</i>-KO mice exhibit an impaired immune response. Neutrophil depletion reconstitution studies demonstrated neutrophils contribute to subsequent eosinophilia are not responsible for ability promote cytokine responses. Transcriptional...
Objective Due to long lag time between infection/cancer diagnoses human papillomavirus (HPV) vaccination programs will deliver vaccine efficacy (VE) estimates against cancer end-points late. Cancer registry follow-up of population-based, randomised trial cohorts vaccinated and unvaccinated women was undertaken for the estimation VE cervical intraepithelial neoplasia grade three invasive (CIN3+). Methods We report interim results with 98 561 person years Finnish Registry -based individually...
There is no prognostic test to ascertain whether cervical intraepithelial neoplasias (CINs) regress or progress. The majority of CINs in young women, and treatments increase the risk adverse pregnancy outcomes. We investigated ability a DNA methylation panel (the S5 classifier) discriminate between outcomes among women with untreated CIN grade 2 (CIN2).
BackgroundWhile prophylactic human papillomavirus (HPV) vaccination exists, women are still developing cervical intraepithelial neoplasia (CIN) grade 2 or 3 for which an immunotherapeutic, non-surgical, approach may be effective. The primary aim was to assess the efficacy of tipapkinogen sovacivec (TS) vaccine in achieving histologic resolution CIN2/3 associated with high risk (HR) HPV types.MethodsWomen 18 years and older who had confirmed were enrolled a randomized, double blind,...
Abstract Optimizing attendance and coverage of organized screening is needed to reduce cervical cancer incidence previous lower levels. In our study, all nonparticipants in 2008 Espoo, Finland were randomized receive a self‐sampling kit (1,130 women) or reminder letter (3,030 women). Effects on assessed according the self‐reported Pap smear history participants. Participation rate arm, 29.8%, was significantly higher than 26.2% (adjusted relative risk for participation 1.13). Total Espoo...
High attendance is essential to cervical cancer screening results. Attendance in the Finnish program currently at 70%, but extensive opportunistic occurs beside organized. A shift from organized imperative optimize costs and impact of minimize potential harms. We evaluated effect reminder letters (1st reminder) self-sampling test (2nd on attendance. The study population consisted 31,053 invitees 31 municipalities. 8,284 non-attendees after one invitation received a letter 4,536 further were...